Additional materials of the author at
CSHL Institutional Repository

Delgado, Ana Paula, Nemajerova, Alice, Rao, Manisha, Li, Jinyu, Marchenko, Natalia, Preall, Jonathan, Moll, Ute, Egeblad, Mikala , Powers, Scott (2022) Single-cell genomic analysis of triple-negative breast cancer fibroblasts uncovers evolutionarily conserved features and potential therapeutic targets. bioRxiv,

Zhao, X. , Powers, S. (2017) New Views into the Genetic Landscape of Metastatic Breast Cancer. Cancer Cell, 32(2) pp. 131-133.

Chen, M., Nowak, D. G., Narula, N., Robinson, B., Watrud, K., Ambrico, A., Herzka, T. M., Zeeman, M. E., Minderer, M., Zheng, W., Ebbesen, S. H., Plafker, K. S., Stahlhut, C., Wang, V. M., Wills, L., Nasar, A., Castillo-Martin, M., Cordon-Cardo, C., Wilkinson, J. E., Powers, S., Sordella, R., Altorki, N. K., Mittal, V., Stiles, B. M., Plafker, S. M. , Trotman, L. C. (2017) The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. J Cell Biol, 216(3) pp. 641-656.

Lee, H. J., Li, C. F., Ruan, D., Powers, S., Thompson, P. A., Frohman, M. A. , Chan, C. H. (2016) The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation. Mol Cell, 63(6) pp. 1021-33.

Scott, K. L. , Powers, S. (2016) Functionally Assessing Candidate Drivers Advances Precision Cancer Medicine. Cancer Cell, 30(2) pp. 187-189.

Gerhard, D. S., Clemons, P. A., Shamji, A. F., Hon, C., Wagner, B. K., Schreiber, S. L., Krasnitz, A., Sordella, R., Sander, C., Lowe, S. W., Powers, S., Smith, K., Aburi, M., Iavarone, A., Lasorella, A., Silva, J., Stockwell, B. R., Califano, A., Boehm, J. S., Vazquez, F., Weir, B. A., Hahn, W. C., Khuri, F. R., Moreno, C. S., Johns, M., Fu, H., Nikolova, O., Mendez, E., Gadi, V. K., Margolin, A. A., Grandori, C., Kemp, C. J., Warren, E. H., Riddell, S. R., McIntosh, M. W., Gevaert, O., Kuo, C. J., Ji, H. P., Dhruv, H., Finlay, D., Kiefer, J., Kim, S., Vuori, K., Berens, M. E., Hangauer, M., Boettcher, M., Weissman, J. S., Bivona, T. G., Bandyopadhyay, S., McManus, M. T., McCormick, F., Aksoy, O., Simonds, E. F., Zheng, T., Chen, J., An, Z., Balmain, A., Weiss, W. A., Chen, K., Liang, H., Scott, K. L., Mills, G. B., Posner, B. A., MacMillan, J., Minna, J., White, M., Roth, M. G., Jagu, S. , Mazerik, J. (2016) Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Mol Cancer Res,

Li, J., Sordella, R. , Powers, S. (2016) Effectors and potential targets selectively upregulated in human KRAS-mutant lung adenocarcinomas. Sci Rep, 6 pp. 27891.

Powers, S. , Pollack, R. E. (2016) Inducing stable reversion to achieve cancer control. Nature Reviews Cancer, 16(4) pp. 266-270.

Wang, X., Chen, M., Yu, X., Pornputtapong, N., Chen, H., Zhang, N., Powers, S. , Krauthammer, M. (2016) Global copy number profiling of cancer genomes. Bioinformatics, 32(6) pp. 926-928.

Wu, S., Powers, S., Zhu, W. , Hannun, Y. A. (2016) Substantial contribution of extrinsic risk factors to cancer development. Nature, 529(7584) pp. 43-7.

Bott, A. J., Peng, I. C., Fan, Y., Faubert, B., Zhao, L., Li, J., Neidler, S., Sun, Y., Jaber, N., Krokowski, D., Lu, W., Pan, J. A., Powers, S., Rabinowitz, J., Hatzoglou, M., Murphy, D. J., Jones, R., Wu, S., Girnun, G. , Zong, W. X. (2015) Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metab, 22(6) pp. 1068-77.

Montal, E. D., Dewi, R., Bhalla, K., Ou, L., Hwang, B. J., Ropell, A. E., Gordon, C., Liu, W. J., DeBerardinis, R. J., Sudderth, J., Twaddel, W., Boros, L. G., Shroyer, K. R., Duraisamy, S., Drapkin, R., Powers, R. S., Rohde, J. M., Boxer, M. B., Wong, K. K. , Girnun, G. D. (2015) PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth. Mol Cell, 60(4) pp. 571-83.

Wang, X., Yu, X., Zhu, W., McCombie, W. R., Antoniou, E., Powers, R. S., Davidson, N. O., Li, E. , Williams, J. (2015) A trimming-and-retrieving alignment scheme for reduced representation bisulfite sequencing. Bioinformatics, 31(12) pp. 2040-2042.

Li, J., Chanrion, M., Sawey, E., Wang, T., Chow, E., Tward, A., Su, Y., Xue, W., Lucito, R., Zender, L., Lowe, S. W., Bishop, J. M. , Powers, S. (2015) Reciprocal Interaction of Wnt and RXR-alpha Pathways in Hepatocyte Development and Hepatocellular Carcinoma. PLoS One, 10(3) pp. e0118480.

Powers, S. (2015) Cooperation between MYC and companion 8q genes in hepatocarcinogenesis. Hepatology, 61(3) pp. 757-8.

Rudalska, R., Dauch, D., Longerich, T., McJunkin, K., Wuestefeld, T., Kang, T. W., Hohmeyer, A., Pesic, M., Leibold, J., von Thun, A., Schirmacher, P., Zuber, J., Weiss, K. H., Powers, S., Malek, N.P., Eilers, M., Sipos, B., Lowe, S. W., Geffers, R., Laufer, S. , Zender, L. (2014) In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer. Nature Medicine, 20(10) pp. 1138-1146.

Catanzaro, J. M., Sheshadri, N., Pan, J. A., Sun, Y., Shi, C., Li, J., Powers, R. S., Crawford, H. C. , Zong, W. X. (2014) Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nature Communications, 5 pp. 3729.

Cleary, S. P., Jeck, W. R., Zhao, X. B., Chen, K., Selitsky, S. R., Savich, G. L., Tan, T. X., Wu, M. C., Getz, G., Lawrence, M. S., Parker, J. S., Li, J. Y., Powers, S., Kim, H., Fischer, S., Guindi, M., Ghanekar, A. , Chiang, D. Y. (2013) Identification of Driver Genes in Hepatocellular Carcinoma by Exome Sequencing. Hepatology, 58(5) pp. 1693-1702.

Rajaram, M., Li, J., Egeblad, M. , Powers, R. S. (2013) System-wide analysis reveals a complex network of tumor-fibroblast interactions involved in tumorigenicity. PLoS Genetics, 9(9) pp. e1003789.

Revill, Kate, Wang, Tim, Lachenmayer, Anja, Kojima, Kensuke, Harrington, Andrew, Li, Jinyu, Hoshida, Yujin, Llovet, Josep M. , Powers, R. Scott (2013) Genome-wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma. Gastroenterology, 145(6) pp. 1424-1435.

Rajaram, M., Zhang, J., Wang, T., Li, J., Kuscu, C., Qi, H., Kato, M., Grubor, V., Weil, R. J., Helland, A., Borrenson-Dale, A. L., Cho, K. R., Levine, D. A., Houghton, A. N., Wolchok, J. D., Myeroff, L., Markowitz, S. D., Lowe, S. W., Zhang, M., Krasnitz, A., Lucito, R., Mu, D. , Powers, R. S. (2013) Two Distinct Categories of Focal Deletions in Cancer Genomes. PLoS ONE, 8(6) pp. e66264.

Cleary, S. P., Jeck, W. R., Zhao, X. B., Selitsky, S. R., Savich, G. L., Tan, T. X., Wu, M. C., Getz, G., Lawrence, M. S., Parker, J. S., Li, J. Y., Powers, S., Kim, H., Fischer, S. E., Guindi, M., Ghanekar, A. , Chiang, D. Y. (2013) Identification of driver genes in hepatocellular carcinoma by exome sequencing. Cancer Research, 73(8 (Sup) pp. 4598.

Mo, Q., Wang, S., Seshan, V. E., Olshen, A. B., Schultz, N., Sander, C., Powers, R. S., Ladanyi, M. , Shen, R. (2013) Pattern discovery and cancer gene identification in integrated cancer genomic data. Proceedings of the National Academy of Sciences of the United States of America, 110(11) pp. 4245-4250.

Eifert, C. , Powers, R. S. (2012) From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets. Nat Rev Cancer, 12(8) pp. 572-578.

Cai, C. L., Rajaram, M., Zhou, X., Liu, Q., Marchica, J., Li, J. Y. , Powers, R. S. (2012) Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3B. Cell Cycle, 11(9) pp. 1773-1781.

Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, A. R., Simon, J., Zhang, J., Luo, W. J., Hicks, J., Zender, L., Wang, X. W., Powers, S., Wigler, M. , Lowe, S. W. (2012) A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America, 109(21) pp. 8212-8217.

Mazurek, A., Luo, W., Krasnitz, A., Hicks, J., Powers, R. S. , Stillman, B. (2012) DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells. Cancer Discovery, 2(9) pp. 812-825.

Liu-Sullivan, N., Zhang, J., Bakleh, A., Marchica, J., Li, J., Siolas, D., Laquerre, S., Degenhardt, Y. Y., Wooster, R., Chang, K., Hannon, G. J. , Powers, S. (2011) Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1). Oncotarget, 2(12) pp. 1254-64.

Storm, P., Aits, S., Puthia, M. K., Urbano, A., Northen, T., Powers, S., Bowen, B., Chao, Y., Reindl, W., Lee, D. Y., Sullivan, N. L., Zhang, J., Trulsson, M., Yang, H., Watson, J. D. , Svanborg, C. (2011) Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis. Oncogene, 30(48) pp. 4765-4779.

Sawey, E. T., Chanrion, M., Cai, C., Wu, G., Zhang, J., Zender, L., Zhao, A., Busuttil, R. W., Yee, H., Stein, L. D., French, D. M., Finn, Richard S, Lowe, S. W. , Powers, S. (2011) Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell, 19(3) pp. 347-358.

Cabal, R., Khanin, R., Viali, A., Socci, N., Lucito, R., Olshen, A., Zhang, J., Gerald, W., Powers, S. , Ladanyi, M. (2011) Testing and Validating High Throughput Genomic Analysis of FFPE Samples: Systematic Gene Expression Differences between Matched Frozen and FFPE Samples Due to Rapid mRNA Degradation Signals. Modern Pathology, 24 pp. 1875.

Schreiber, S. L., Shamji, A. F., Clemons, P. A., Hon, C., Koehler, A. N., Munoz, B., Palmer, M., Stern, A. M., Wagner, B. K., Powers, S., Lowe, S. W., Guo, X., Krasnitz, A., Sawey, E. T., Sordella, R., Stein, L. D., Trotman, L. C., Califano, A., Dalla-Favera, R., Ferrando, A., Iavarone, A., Pasqualucci, L., Silva, J., Stockwell, B. R., Hahn, W. C., Chin, L., DePinho, R. A., Boehm, J. S., Gopal, S., Huang, A., Root, D. E., Weir, B. A., Gerhard, D. S., Zenklusen, J. C., Roth, M. G., White, M. A., Minna, J. D., MacMillan, J. B. , Posner, B. A. (2010) Towards patient-based cancer therapeutics. Nature Biotechnology, 28(9) pp. 904-906.

Trotman, L. C. , Powers, S. (2010) New views into the prostate cancer genome. Cancer Cell, 18(1) pp. 1-2.

Degenhardt, Y., Greshock, J., Laquerre, S., Gilmartin, A. G., Jing, J., Richter, M., Zhang, X., Bleam, M., Halsey, W., Hughes, A., Moy, C., Liu-Sullivan, N., Powers, S., Bachman, K., Jackson, J., Weber, B. , Wooster, R. (2010) Sensitivity of Cancer Cells to Plk1 Inhibitor GSK461364A Is Associated with Loss of p53 Function and Chromosome Instability. Molecular Cancer Therapeutics, 9(7) pp. 2079-2089.

Oliver, T. G., Mercer, K. L., Sayles, L. C., Burke, J. R., Mendus, D., Lovejoy, K. S., Cheng, M. H., Subramanian, A., Mu, D., Powers, S., Crowley, D., Bronson, R. T., Whittaker, C. A., Bhutkar, A., Lippard, S. J., Golub, T., Thomale, J., Jacks, T. , Sweet-Cordero, E. A. (2010) Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes & Development, 24(8) pp. 837-852.

Bric, A., Miething, C., Bialucha, C. U., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M. H., Hicks, J. B., McCombie, W. R., Hemann, M. T., Hannon, G. J., Powers, S. , Lowe, S. W. (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell, 16(4) pp. 324-35.

Hsu, D. S., Acharya, C. R., Balakumaran, B. S., Riedel, R. F., Kim, M. K., Stevenson, M., Tuchman, S., Mukherjee, S., Barry, W., Dressman, H. K., Nevins, J. R., Powers, S., Mu, D. , Potti, A. (2009) Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. Proc Natl Acad Sci U S A, 106(13) pp. 5312-5317.

Starr, T. K., Allaei, R., Silverstein, K. A. T., Staggs, R. A., Sarver, A. L., Bergemann, T. L., Gupta, M., O'Sullivan, M. G., Matise, I., Dupuy, A. J., Collier, L. S., Powers, S., Oberg, A. L., Asmann, Y. W., Thibodeau, S. N., Tessarollo, L., Copeland, N. G., Jenkins, N. A., Cormier, R. T. , Largaespada, D. A. (2009) A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer. Science, 323(5922) pp. 1747-1750.

Keng, V. W., Villanueva, A., Chiang, D. Y., Dupuy, A. J., Ryan, B. J., Matise, I., Silverstein, K. A. T., Sarver, A., Starr, T. K., Akagi, K., Tessarollo, L., Collier, L. S., Powers, S., Lowe, S. W., Jenkins, N. A., Copeland, N. G., Llovet, J. M. , Largaespada, D. A. (2009) A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nature Biotechnology, 27(3) pp. 264-274.

Silva, J. M., Ezhkova, E., Silva, J., Heart, S., Castillo, M., Campos, Y., Castro, V., Bonilla, F., Cordon-Cardo, C., Muthuswamy, S. K., Powers, S., Fuchs, E. , Hannon, G. J. (2009) Cyfip1 Is a Putative Invasion Suppressor in Epithelial Cancers. Cell, 137(6) pp. 1047-1061.

Sangha, N., Wu, R., Kuick, R., Powers, S., Mu, D., Fiander, D., Yuen, K., Katabuchi, H., Tashiro, H., Fearon, E. R. , Cho, K. R. (2008) Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations. Neoplasia, 10(12) pp. 1362-72.

Zender, L., Xue, W., Zuber, J., Semighini, C. P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J. M., Schirmacher, P., McCombie, W. R., Wigler, M. H., Hicks, J. B., Hannon, G. J., Powers, S. , Lowe, S. W. (2008) An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell, 135(5) pp. 852-864.

Miao, J., Mu, D., Ergel, B., Singavarapu, R., Duan, Z., Powers, S., Oliva, E. , Orsulic, S. (2008) Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model. Int J Cancer, 123(9) pp. 2041-7.

Xue, W., Krasnitz, A., Lucito, R., Sordella, R., Van Aelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M. H., Powers, S., Zender, L. , Lowe, S. W. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development, 22(11) pp. 1439-44.

Sinclair, A. M., Rogers, N., Busse, L., Archibeque, I., Brown, W., Kassner, P. D., Watson, J. E. V., Arnold, G. E., Nguyen, K. C. Q., Powers, S. , Elliott, S. (2008) Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells. British Journal of Cancer, 98(6) pp. 1059-1067.

Degenhardt, Y. Y., Wooster, R., McCombie, R. W., Lucito, R. , Powers, S. (2008) High-content analysis of cancer genome DNA alterations. Current Opinion in Genetics & Development, 18(1) pp. 68-72.

Powers, S. , Mu, D. (2008) Genetic similarities between organogenesis and tumorigenesis of the lung. Cell Cycle, 7(2) pp. 200 - 204 .

Kendall, J. T., Liu, Q. A., Bakleh, A., Krasnitz, A., Nguyen, K. C. Q., Lakshmi, B., Gerald, W., Powers, S. , Mu, D. (2007) Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer. Proc Natl Acad Sci U S A, 104(42) pp. 16663-16668.

Pelham, R. J., Rodgers, L., Hall, I. M., Lucito, R., Nguyen, K. C. Q., Navin, N. E., Hicks, J. B., Mu, D., Powers, S., Wigler, M. H. , Botstein, D. (2006) Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc Natl Acad Sci U S A, 103(52) pp. 19848-19853.

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S. T., Luk, J. M., Wigler, M. H., Hannon, G. J., Mu, D., Lucito, R., Powers, S. , Lowe, S. W. (2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell, 125(7) pp. 1253-67.

van der Horst, E. H., Degenhardt, Y. Y., Strelow, A., Slavin, A., Chinn, L., Orf, J., Rong, M., Li, S., See, L. H., Nguyen, K. Q., Hoey, T., Wesche, H. , Powers, S. (2005) Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proceedings of the National Academy of Sciences of the United States of America, 102(44) pp. 15901-6.

Zender, L., Spector, M. S., Xue, W., Flemming, P., Mu, D., Cordon-Cardo, C., Powers, S., Hannon, G. J., Lucito, R. , Lowe, S. W. (2005) Representational oligonucleotide microarray (ROMA) identifies cIAP1/cIAP2 as candidate oncogenes in mouse and human hepatocarcinogenesis-validation of cIAP1 as a therapeutic target in liver cancer in a new mouse model of hepatocellular carcinoma. Hepatology, 42(4) pp. 244A-244A.

He, L., Thomson, J. M., Hemann, M. T., Hernando-Monge, E., Mu, D., Goodson, S., Powers, S., Cordon-Cardo, C., Lowe, S. W., Hannon, G. J. , Hammond, S. M. (2005) A microRNA polycistron as a potential human oncogene. Nature, 435(7043) pp. 828-33.

Zender, L., Xue, W., Cordon-Cardo, C., Hannon, G. J., Lucito, R., Powers, S., Flemming, P., Spector, M. S. , Lowe, S. W. (2005) Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors. Cold Spring Harb Symp Quant Biol, 70(1) pp. 251-261.

Harrison, M., Li, J., Degenhardt, Y., Hoey, T. , Powers, S. (2004) Wip1-deficient mice are resistant to common cancer genes. Trends in Molecular Medicine, 10(8) pp. 359-361.

Lucito, R., Healy, J., Alexander, J., Reiner, A., Esposito, D., Chi, M. Y., Rodgers, L., Brady, A., Sebat, J., Troge, J. E., West, J. A., Rostan, S., Nguyen, K. C. Q., Powers, S., Ye, K. Q., Olshen, A., Venkatraman, E., Norton, L. , Wigler, M. H. (2003) Representational oligonucleotide microarray analysis: A high-resolution method to detect genome copy number variation. Genome Research, 13(10) pp. 2291-2305.

Pei, L., Wiser, O., Slavin, A., Mu, D., Powers, S., Jan, L. Y. , Hoey, T. (2003) Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function. Proceedings of the National Academy of Sciences of the United States of America, 100(13) pp. 7803-7.

Mu, D., Chen, L. Y., Zhang, X. P., See, L. H., Koch, C. M., Yen, C., Tong, J. J., Spiegel, L., Nguyen, K. C. Q., Servoss, A., Peng, Y., Pei, L., Marks, J. R., Lowe, S. W., Hoey, T., Jan, L. Y., McCombie, W. R., Wigler, M. H. , Powers, S. (2003) Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3(3) pp. 297-302.

Pei, L., Peng, Y., Yang, Y., Ling, X. B., Van Eyndhoven, W. G., Nguyen, K. C., Rubin, M., Hoey, T., Powers, S. , Li, J. (2002) PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. Cancer Res, 62(19) pp. 5420-4.

Li, J., Yang, Y., Peng, Y., Austin, R. J., van Eyndhoven, G., Nguyen, K. C. Q., Gabriele, T., McCurrach, M. E., Marks, J. R., Hoey, T., Lowe, S. W. , Powers, S. (2002) Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nature Genetics, 31(2) pp. 133-134.

Shields, J. M., Der, C. J. , Powers, S. (2001) Identification of Ras-regulated genes by representational difference analysis. Methods in Enzymology, 332 pp. 221-32.

Lucito, R., West, J., Reiner, A., Alexander, J., Esposito, D., Mishra, B., Powers, S., Norton, L. , Wigler, M. H. (2000) Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations. Genome Research, 10(11) pp. 1726-1736.

Bhattacharya, S., Chen, L., Broach, J. R. , Powers, S. (1995) Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Proceedings of the National Academy of Sciences of the United States of America, 92(7) pp. 2984-8.

Jung, V., Chen, L., Hofmann, S. L., Wigler, M. H. , Powers, S. (1995) Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Mol Cell Biol, 15(3) pp. 1333-42.

Chen, L. , Powers, S. (1995) RAS in yeast: complementation assays for test of function. Methods in Enzymology, 255 pp. 465-8.

Hart, M. , Powers, S. (1995) Ras-Cdc25 and Rho-Dbl binding assays: complex formation in vitro. Methods in Enzymology, 255 pp. 129-35.

Chen, L. , Powers, S. (1994) A mutation in the effector region of Ras2 can be partially suppressed by alteration of a 'nonessential' region of Ras. Gene, 147(1) pp. 107-10.

Chen, S. Y., Huff, S. Y., Lai, C. C., Der, C. J. , Powers, S. (1994) Ras-15A protein shares highly similar dominant-negative biological properties with Ras-17N and forms a stable, guanine-nucleotide resistant complex with CDC25 exchange factor. Oncogene, 9(9) pp. 2691-8.

Beranger, F., Cadwallader, K., Porfiri, E., Powers, S., Evans, T., de Gunzburg, J. , Hancock, J. F. (1994) Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase. Journal of Biological Chemistry, 269(18) pp. 13637-43.

Beranger, F., Paterson, H., Powers, S., de Gunzburg, J. , Hancock, J. F. (1994) The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization. Mol Cell Biol, 14(1) pp. 744-58.

Omer, C. A., Kral, A. M., Diehl, R. E., Prendergast, G. C., Powers, S., Allen, C. M., Gibbs, J. B. , Kohl, N. E. (1993) Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. Biochemistry, 32(19) pp. 5167-76.

Lai, C. C., Boguski, M., Broek, D. , Powers, S. (1993) Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins. Mol Cell Biol, 13(3) pp. 1345-52.

Thorburn, A., Thorburn, J., Chen, S. Y., Powers, S., Shubeita, H. E., Feramisco, J. R. , Chien, K. R. (1993) HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. Journal of Biological Chemistry, 268(3) pp. 2244-9.

Powers, S. (1992) Genetic analysis of ras homologs in yeasts. Semin Cancer Biol, 3(4) pp. 209-18.

Boguski, M. S., Murray, A. W. , Powers, S. (1992) Novel repetitive sequence motifs in the alpha and beta subunits of prenyl-protein transferases and homology of the alpha subunit to the MAD2 gene product of yeast. The New Biologist, 4(4) pp. 408-11.

Ruggieri, R., Bender, A., Matsui, Y., Powers, S., Takai, Y., Pringle, J. R. , Matsumoto, K. (1992) RSR1, a ras-like gene homologous to Krev-1 (smg21A/rap1A): role in the development of cell polarity and interactions with the Ras pathway in Saccharomyces cerevisiae. Molecular and Cellular Biology, 12(2) pp. 758-66.

He, B., Chen, P., Chen, S. Y., Vancura, K. L., Michaelis, S. , Powers, S. (1991) RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins. Proceedings of the National Academy of Sciences of the United States of America, 88(24) pp. 11373-7.

Kohl, N. E., Diehl, R. E., Schaber, M. D., Rands, E., Soderman, D. D., He, B., Moores, S. L., Pompliano, D. L., Ferro-Novick, S. , Powers, S. (1991) Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases. Journal of Biological Chemistry, 266(28) pp. 18884-8.

Kim, J. H. , Powers, S. (1991) Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function. Molecular and Cellular Biology, 11(8) pp. 3894-904.

Powers, S., Gonzales, E., Christensen, T., Cubert, J. , Broek, D. (1991) Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant. Cell, 65(7) pp. 1225-31.

Powers, S. (1991) Protein prenylation: a modification that sticks. Current Biology, 1(2) pp. 114-6.

Goodman, L. E., Judd, S. R., Farnsworth, C. C., Powers, S., Gelb, M. H., Glomset, J. A. , Tamanoi, F. (1990) Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins. Proceedings of the National Academy of Sciences of the United States of America, 87(24) pp. 9665-9.

Field, J., Vojtek, A., Ballester, R., Bolger, G., Colicelli, J., Ferguson, K., Gerst, J., Kataoka, T., Michaeli, T., Powers, S., Riggs, M., Rodgers, L., Wieland, I., Wheland, B. , Wigler, M. H. (1990) Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein. Cell, 61(2) pp. 319-327.

Powers, S., O'Neill, K. , Wigler, M. H. (1989) Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Molecular & Cellular Biology, 9(2) pp. 390-5.

Levin, L. R., Kuret, J., Johnson, K. E., Powers, S., Cameron, S., Michaeli, T., Wigler, M. H. , Zoller, M. J. (1988) A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. Science, 240(4848) pp. 68-70.

Wigler, M. H., Field, J., Powers, S., Broek, D., Toda, T., Cameron, S., Nikawa, J., Michaeli, T., Colicelli, J. , Ferguson, K. (1988) Studies of RAS function in the yeast Saccharomyces cerevisiae. Cold Spring Harbor Symposia on Quantitative Biology, 53(2) pp. 649-55.

Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S. , Wigler, M. H. (1987) The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway . Cell, 48(5) pp. 789-800.

Michaelis, S., Anna, S. S., Powers, S., Wigler, M. H. , Herskowitz, I. (1987) Yeast Mating Pheromone a-Factor and Its Relationship to Ras Proteins. Journal of Cellular Biochemistry, pp. 261-261.

Powers, S., Michaelis, S., Broek, D., Ann-A, S. S., Field, J., Herskowitz, I. , Wigler, M. H. (1986) RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell, 47(3) pp. 413-422.

Birchmeier, C., Broek, D., Toda, T., Powers, S., Kataoka, T. , Wigler, M. H. (1985) Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposia on Quantitative Biology, 50 pp. 721-725.

Broach, J., Toda, T., Kataoka, T., Powers, S., Broek, D. , Wigler, M. H. (1985) Ras Proteins Function Exclusively to Modulate Adenylate-Cyclase Activity in the Yeast Saccharomyces. DNA-a Journal of Molecular & Cellular Biology, 4(1) pp. 64-64.

Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J. , Wigler, M. H. (1985) Functional homology of mammalian and yeast RAS genes. Cell, 40(1) pp. 19-26.

Powers, S., Kataoka, T., Toda, T., Fasano, O. , Wigler, M. H. (1985) Control of Yeast Adenyl-Cyclase by Ras Proteins. Federation Proceedings, 44(3) pp. R8-R8.

Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K. , Wigler, M. H. (1985) In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell, 40(1) pp. 27-36.

Powers, S., Fisher, P. B. , Pollack, R. (1984) Analysis of the reduced growth factor dependency of simian virus 40-transformed 3T3 cells. Molecular and Cellular Biology, 4(8) pp. 1572-6.

Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J. , Wigler, M. H. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell, 37(2) pp. 437-445.

Murphy, R. F., Powers, S. , Cantor, C. R. (1984) Endosome pH measured in single cells by dual fluorescence flow cytometry: rapid acidification of insulin to pH 6. Journal of Cell Biology, 98(5) pp. 1757-62.

Murphy, R. F., Powers, S., Cantor, C. R. , Pollack, R. (1984) Reduced insulin endocytosis in serum-transformed fibroblasts demonstrated by flow cytometry. Cytometry, 5(3) pp. 275-80.

Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J. , Wigler, M. H. (1984) Genes in Saccharomyces cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell, 36(3) pp. 607-612.

Murphy, R. F., Powers, S., Verderame, M., Cantor, C. R. , Pollack, R. (1982) Flow cytofluorometric analysis of insulin binding and internalization by Swiss 3T3 cells. Cytometry, 2(6) pp. 402-6.