Additional materials of the author at
CSHL Institutional Repository

Park, S., Brugiolo, M., Akerman, M., Das, S., Urbanski, L., Geier, A., Kesarwani, A. K., Fan, M., Leclair, N., Lin, K. T., Hu, L., Hua, I., George, J., Muthuswamy, S. K., Krainer, A. R. , Anczukow, O. (2019) Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. Cell Rep, 29(9) pp. 2672-2688.e7.

Ramesh, M., Krishnan, N., Muthuswamy, S. K. , Tonks, N. K. (2015) A Novel Phosphatidic Acid-Protein Tyrosine Phosphatase D2 Axis is Essential for ERBB2 Signaling in Mammary Epithelial Cells. Journal of Biological Chemistry, 290(15) pp. 9646-9659.

Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., Jensen, M. R., Gauss, C. M., Page, R., Blackledge, M., Muthuswamy, S. K., Peti, W. , Tonks, N. K. (2014) Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 10(7) pp. 558-566.

Feigin, M. E., Xue, B., Hammell, M. C. , Muthuswamy, S. K. (2014) G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. Proceedings of the National Academy of Sciences of the United States of America, 111(11) pp. 4191-6.

Wang, H., Lacoche, S., Huang, L., Xue, B. , Muthuswamy, S. K. (2013) Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly. Proceedings of the National Academy of Sciences of the United States of America, 110(1) pp. 163-168.

Xue, B., Krishnamurthy, K., Allred, D. C. , Muthuswamy, S. K. (2013) Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nature Cell Biology, 15(2) pp. 189-200.

Muthuswamy, S. K. (2012) Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports. Genes Dev, 26(20) pp. 2253-8.

Yu, M., Lin, G., Arshadi, N., Kalatskaya, I., Xue, B., Haider, S., Nguyen, F., Boutros, P. C., Elson, A., Muthuswamy, L. B., Tonks, N. K. , Muthuswamy, S. K. (2012) Expression profiling during mammary epithelial cell 3D morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2 mediated transformation. Mol Cell Biol, 32(19) pp. 3913-3924.

Yang, Z., Xue, B., Umitsu, M., Ikura, M., Muthuswamy, S. K. , Neel, B. G. (2012) The Signaling Adaptor Gab1 Regulates Cell Polarity by Acting as a PAR Protein Scaffold. Molecular Cell, 47(3) pp. 469-483.

Muthuswamy, S. K. , Xue, B. (2012) Cell Polarity as a Regulator of Cancer Cell Behavior Plasticity. Annu Rev Cell Dev Biol, 28(28) pp. 599-625.

Chatterjee, S., Seifried, L., Feigin, M. E., Gibbons, D. L., Scuoppo, C., Lin, W., Rizvi, Z. H., Lind, E., Dissanayake, D., Kurie, J., Ohashi, P. , Muthuswamy, S. K. (2012) Dysregulation of Cell Polarity Proteins Synergize with Oncogenes or the Microenvironment to Induce Invasive Behavior in Epithelial Cells. PLoS ONE, 7(4)

Anczukow, O., Rosenberg, A. Z., Akerman, M., Das, S., Zhan, L., Karni, R., Muthuswamy, S. K. , Krainer, A. R. (2012) The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural Molecular Biology, 19(2) pp. 220-228.

Lin, G., Aranda, V., Muthuswamy, S. K. , Tonks, N. K. (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes & Development, 25(13) pp. 1412-1425.

Simpson, D. R., Yu, M., Zheng, S. Y., Zhao, Z. M., Muthuswamy, S. K. , Tansey, W. P. (2011) Epithelial Cell Organization Suppresses Myc Function by Attenuating Myc Expression. Cancer Research, 71(11) pp. 3822-3830.

Muthuswamy, S. K. (2011) Trastuzumab resistance: all roads lead to SRC. Nature Medicine, 17(4) pp. 416-8.

Keyes, W. M., Pecoraro, M., Aranda, V., Vernersson-Lindahl, E., Li, W., Vogel, H., Guo, X., Garcia, E. L., Michurina, T. V., Enikolopov, G. N., Muthuswamy, S. K. , Mills, A. A. (2011) DeltaNp63alpha Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis. Cell Stem Cell, 8(2) pp. 164-76.

Muthuswamy, S. K. (2011) 3D culture reveals a signaling network. Breast Cancer Research, 13(1)

Arias-Romero, L. E., Villamar-Cruz, O., Pacheco, A., Kosoff, R., Huang, M., Muthuswamy, S. K. , Chernoff, J. (2010) A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene, 29(43) pp. 5839-49.

Cabodi, S., Tinnirello, A., Bisaro, B., Tornillo, G., Camacho-Leal, M. D., Forni, G., Cojoca, R., Iezzi, M., Amici, A., Montani, M., Eva, A., Di Stefano, P., Muthuswamy, S. K., Tarone, G., Turco, E. , Defilippi, P. (2010) p130Cas is an essential transducer element in ErbB2 transformation. Faseb J, 24(10) pp. 3796-3808.

Huang, L. , Muthuswamy, S. K. (2010) Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Current Opinion in Genetics and Development, 20(1) pp. 41-50.

Lucs, A. V., Muller, W. J. , Muthuswamy, S. K. (2010) Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene, 29(2) pp. 174-187.

Ling, C., Zuo, D., Xue, B., Muthuswamy, S. K. , Muller, W. J. (2010) A novel role for 14-3-3σ in regulating epithelial cell polarity. Genes and Development, 24(9) pp. 947-956.

Feigin, M. E. , Muthuswamy, S. K. (2009) Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol, 21(5) pp. 694-700 .

Muthuswamy, S. K. (2009) A New Tumor Suppressor That Regulates Tissue Architecture. PLoS Medicine, 6(5) pp. e1000073.

Silva, J. M., Ezhkova, E., Silva, J., Heart, S., Castillo, M., Campos, Y., Castro, V., Bonilla, F., Cordon-Cardo, C., Muthuswamy, S. K., Powers, S., Fuchs, E. , Hannon, G. J. (2009) Cyfip1 Is a Putative Invasion Suppressor in Epithelial Cancers. Cell, 137(6) pp. 1047-1061.

Zavadil, J., Haley, J., Kalluri, R., Muthuswamy, S. K. , Thompson, E. (2008) Epithelial-Mesenchymal Transition. Cancer Res, 68(23) pp. 9574-9577.

Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z. Y., Jaffe, A. B., Allred, C. , Muthuswamy, S. K. (2008) Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma. Cell, 135(5) pp. 865-878.

Aranda, V., Nolan, M. E. , Muthuswamy, S. K. (2008) Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene, 27(55) pp. 6878-87.

Nolan, M. E., Aranda, V., Lee, S., Lakshmi, B., Basu, S., Allred, D. C. , Muthuswamy, S. K. (2008) The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res, 68(20) pp. 8201-9.

Xiang, B., Chatti, K., Qiu, H., Lakshmi, B., Krasnitz, A., Hicks, J. B., Yu, M., Miller, W. T. , Muthuswamy, S. K. (2008) Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A, 105(34) pp. 12463-8.

Guix, M., de Matos Granja, N., Meszoely, I., Adkins, T. B., Wieman, B. M., Frierson, K. E., Sanchez, V., Sanders, M. E., Grau, A. M., Mayer, I. A., Pestano, G., Shyr, Y., Muthuswamy, S., Calvo, B., Krontiras, H., Krop, I. E., Kelley, M. C. , Arteaga, C. L. (2008) Short Preoperative Treatment With Erlotinib Inhibits Tumor Cell Proliferation in Hormone Receptor Positive Breast Cancers. J Clin Oncol, 26(6) pp. 897-906.

Feigin, M. E. , Muthuswamy, S. K. (2008) ErbB receptors and cell polarity: New pathways and paradigms for understanding cell migration and invasion. Experimental Cell Research, 315(4) pp. 707-716.

Ibarra, I., Erlich, Y., Muthuswamy, S. K., Sachidanandam, R. , Hannon, Gregory J. (2007) A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev, 21(24) pp. 3238-43.

Tonks, N. K. , Muthuswamy, S. K. (2007) A Brake Becomes an Accelerator: PTP1B-A New Therapeutic Target for Breast Cancer. Cancer Cell, 11(3) pp. 214-6.

Aranda, V., Haire, T., Nolan, M. E., Calarco, J. P., Rosenberg, A. Z., Fawcett, J. P., Pawson, T. , Muthuswamy, S. K. (2006) Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol, 8(11) pp. 1235-45.

Muthuswamy, S. K. (2006) ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. Cell, 126(3) pp. 443-5.

Zhan, L., Xiang, B. , Muthuswamy, S. K. (2006) Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res, 66(10) pp. 5201-8.

Reginato, M. J. , Muthuswamy, S. K. (2006) Illuminating the center: Mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Journal of Mammary Gland Biology and Neoplasia, 11(3-4) pp. 205-211.

Wang, S. E., Narasanna, A., Perez-Torres, M., Xiang, B., Wu, F. Y., Yang, S., Carpenter, G., Gazdar, A. F., Muthuswamy, S. K. , Arteaga, C. L. (2006) HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell, 10(1) pp. 25-38.

Xiang, B. , Muthuswamy, S. K. (2006) Using three-dimensional acinar structures for molecular and cell biological assays. Methods Enzymol, 406 pp. 692-701.

Muthuswamy, S. K. (2005) Regulation of epithelial cell polarity during carcinogenesis. Breast Cancer Research, 7 pp. S7-S7.

Debnath, J., Muthuswamy, S. K. , Brugge, J. S. (2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods, 30(3) pp. 256-268.

Miranti, C. K., Bill, H. M., Modres, S. L., Rao, V. R., Knudsen, B., Muthuswamy, S. K. , Brugge, J. S. (2003) Integrin-induced EGFR activation and control of the cell cycle in epithelial cells. Faseb Journal, 17(5) pp. A974-A974.

Reginato, M. J., Mills, K., Debnath, J., Paulus, J., Muthuswamy, S. , Brugge, J. (2002) Bim regulation or lumen formation in epithelial acini is blocked by oncogenes. Molecular Biology of the Cell, 13 pp. 4A-4A.

Muthuswamy, S. K., Li, D. M., Lelievre, S., Bissell, M. J. , Brugge, J. S. (2001) ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nature Cell Biology, 3(9) pp. 785-792.