Additional materials of the author at
CSHL Institutional Repository

Fisher, Matthew L, Balinth, Seamus, Hwangbo, Yon, Wu, Caizhi, Ballon, Carlos, Goldberg, Gary L , Mills, Alea A (2023) Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma. Carcinogenesis, 44(6) pp. 485-496.

Shrestha, Padmina, Jaganathan, Anbalagan, Huilgol, Dhananjay, Ballon, Carlos, Hwangbo, Yon , Mills, Alea A (2023) Chd5 regulates the transcription factor Six3 to promote neuronal differentiation. Stem Cells, pp. sxad002.

Sun, Xueqin, Klingbeil, Olaf, Lu, Bin, Wu, Caizhi, Ballon, Carlos, Ouyang, Meng, Wu, Xiaoli S, Jin, Ying, Hwangbo, Yon, Huang, Yu-Han, Somerville, Tim DD, Chang, Kenneth, Park, Jung, Chung, Taemoon, Lyons, Scott K, Shi, Junwei, Vogel, Hannes, Schulder, Michael, Vakoc, Christopher R , Mills, Alea A (2022) BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network. Nature,

Fisher, Matthew L, Balinth, Seamus , Mills, Alea A (2022) ΔNp63α in cancer: importance and therapeutic opportunities. Trends in Cell Biology, pp. S0962-8924(22)00194.

Balinth, Seamus, Fisher, Matthew L, Hwangbo, Yon, Wu, Caizhi, Ballon, Carlos, Sun, Xueqin , Mills, Alea A (2022) EZH2 regulates a SETDB1/ΔNp63α axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma. Oncogene,

Stefanski, Heather E, Xing, Yan, Nicholls, Jemma, Jonart, Leslie, Goren, Emily, Taylor, Patricia A, Mills, Alea A, Riddle, Megan, McGrath, John, Tolar, Jakub, Hollander, Georg A , Blazar, Bruce R (2022) P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss. PLoS One, 17(1)

Fisher, Matthew L, Balinth, Seamus, Hwangbo, Yon, Wu, Caizhi, Ballon, Carlos, Wilkinson, John E, Goldberg, Gary L , Mills, Alea A (2021) BRD4 REGULATES TRANSCRIPTION FACTOR ∆Np63αTO DRIVE A CANCER STEM CELL PHENOTYPE IN SQUAMOUS CELL CARCINOMAS. Cancer Research, pp. canres.0707.2021-canres.0707.2021.

Fisher, M. L., Balinth, S. , Mills, A. A. (2020) p63-related signaling at a glance. J Cell Sci, 133(17)

Rein, B., Tan, T., Yang, F., Wang, W., Williams, J., Zhang, F., Mills, A. , Yan, Z. (2020) Reversal of Synaptic and Behavioral Deficits in a 16p11.2 Duplication Mouse Model via Restoration of the GABA Synapse Regulator Npas4. Mol Psychiatry,

Hershlag, A., Peyser, A., Bristow, S. L., Puig, O., Pollock, A., Niknazar, M. , Mills, A. A. (2019) The potential impact of tumor suppressor genes on human gametogenesis: a case-control study. J Assist Reprod Genet,

Lu, H. C., Pollack, H., Lefante, J. J., Mills, A. A. , Tian, D. (2018) Altered sleep architecture, rapid eye movement (REM) sleep, and neural oscillation in a mouse model of human chromosome 16p11.2 microdeletion. Sleep, 42(3)

Hwang, D. W., Jaganathan, A., Shrestha, P., Jin, Y., El-Amine, N., Wang, S. H., Hammell, M. , Mills, A. A. (2018) Chromatin-mediated translational control is essential for neural cell fate specification. Life Sci Alliance, 1(4) pp. e201700016.

Lu, H. C., Mills, A. A. , Tian, D. (2018) Altered synaptic transmission and maturation of hippocampal CA1 neurons in a mouse model of human chr16p11.2 microdeletion. J Neurophysiol, 119(3) pp. 1005-1018.

Peyser, A., Bristow, S. L., Puig, O., Pollock, A., Mills, A., Niknazar, M. , Hershlag, A. (2017) Do mutations in CHD5 cause male infertility?. Fertility and Sterility, 108(3, Sup) pp. e140-e141.

Peyser, A., Bristow, S. L., Puig, O., Pollock, A., Mills, A., Niknazar, M. , Hershlag, A. (2017) Do tumor suppressor genes (TSG) play a role in diminished ovarian reserve (DOR). Fertility and Sterility, 108(3, Sup) pp. e220.

Taniguchi, Y., Kawata, M., Ho Chang, S., Mori, D., Okada, K., Kobayashi, H., Sugita, S., Hosaka, Y., Inui, H., Taketomi, S., Yano, F., Ikeda, T., Akiyama, H., Mills, A. A., Chung, U. I., Tanaka, S., Kawaguchi, H. , Saito, T. (2017) Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63. Arthritis and Rheumatology, 69(3) pp. 598-609.

Mills, A. A. (2017) The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer. Cold Spring Harb Perspect Med,

Kawata, M., Taniguchi, Y., Mori, D., Yano, F., Ohba, S., Chung, U. I., Shimogori, T., Mills, A. A., Tanaka, S. , Saito, T. (2017) Different regulation of limb development by p63 transcript variants. PLoS One, 12(3) pp. e0174122.

Liu, Y., Chen, C., Xu, Z., Scuoppo, C., Rillahan, C. D., Gao, J., Spitzer, B., Bosbach, B., Kastenhuber, E. R., Baslan, T., Ackermann, S., Cheng, L., Wang, Q., Niu, T., Schultz, N., Levine, R. L., Mills, A. A. , Lowe, S. W. (2016) Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature, 531(7595) pp. 471-475.

Zepeda-Mendoza, C. J., Mukhopadhyay, S., Wong, E. S., Harder, N., Splinter, E., de Wit, E., Eckersley-Maslin, M. A., Ried, T., Eils, R., Rohr, K., Mills, A., de Laat, W., Flicek, P., Sengupta, A. M. , Spector, D. L. (2015) Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2. BMC Genomics, 16(1) pp. 982.

Brunner, D., Kabitzke, P., He, D., Cox, K., Thiede, L., Hanania, T., Sabath, E., Alexandrov, V., Saxe, M., Peles, E., Mills, A., Spooren, W., Ghosh, A., Feliciano, P., Benedetti, M., Luo Clayton, A. , Biemans, B. (2015) Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder. PLoS One, 10(8) pp. e0134572.

Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J. N., Lin, L., Genestine, M., DiCicco-Bloom, E., Lai, J. K., Foster, J. A., Penagarikano, O., Geschwind, D. H., Pacey, L. K., Hampson, D. R., Laliberte, C. L., Mills, A. A., Tam, E., Osborne, L. R., Kouser, M., Espinosa-Becerra, F., Xuan, Z., Powell, C. M., Raznahan, A., Robins, D. M., Nakai, N., Nakatani, J., Takumi, T., van Eede, M. C., Kerr, T. M., Muller, C., Blakely, R. D., Veenstra-VanderWeele, J., Henkelman, R. M. , Lerch, J. P. (2015) Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol Psychiatry, 20(1) pp. 118-125.

Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J. N., Lin, L., Genestine, M., DiCicco-Bloom, E., Lai, J. K., Foster, J. A., Penagarikano, O., Geschwind, D. H., Pacey, L. K., Hampson, D. R., Laliberte, C. L., Mills, A. A., Tam, E., Osborne, L. R., Kouser, M., Espinosa-Becerra, F., Xuan, Z., Powell, C. M., Raznahan, A., Robins, D. M., Nakai, N., Nakatani, J., Takumi, T., van Eede, M. C., Kerr, T. M., Muller, C., Blakely, R. D., Veenstra-VanderWeele, J., Henkelman, R. M. , Lerch, J. P. (2015) 3D visualization of the regional differences. Mol Psychiatry, 20(1) pp. 1.

Tian, D., Stoppel, L. J., Heynen, A. J., Lindemann, L., Jaeschke, G., Mills, A. A. , Bear, M. F. (2015) Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion. Nature Neuroscience, 18 pp. 182-184.

Li, Wanhe , Mills, Alea A. (2014) Architects of the genome: CHD dysfunction in cancer, developmental disorders and neurological syndromes. Epigenomics, 6(4) pp. 381-95.

Li, W. , Mills, A. A. (2014) Packing for the journey: CHD5 remodels the genome. Cell Cycle, 13(12)

Li, W., Wu, J., Kim, S. Y., Zhao, M., Hearn, S. A., Zhang, M. Q., Meistrich, M. L. , Mills, A. A. (2014) Chd5 orchestrates chromatin remodelling during sperm development. Nature Communications, 5 pp. 3812.

Vestin, A. , Mills, A. A. (2013) The tumor suppressor Chd5 is induced during neuronal differentiation, in the developing mouse brain. Gene Expression Patterns, 13(8) pp. 482-489.

Kim, S. Y., Cordeiro, M. H., Serna, V. A., Ebbert, K., Butler, L. M., Sinha, S., Mills, A. A., Woodruff, T. K. , Kurita, T. (2013) Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network. Cell Death and Differentiation, 20(8) pp. 987-997.

Ramsey, M. R., Wilson, C., Ory, B., Rothenberg, S. M., Faquin, W., Mills, A. A. , Ellisen, L. W. (2013) FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. Journal of Clinical Investigation, 123(8) pp. 3525-3538.

Laronda, Monica M., Unno, Kenji, Ishi, Kazutomo, Serna, Vanida A., Butler, Lindsey M., Mills, Alea A., Orvis, Grant D., Behringer, Richard R., Deng, Chuxia, Sinha, Satrajit , Kurita, Takeshi (2013) Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium. Developmental Biology, 381(1) pp. 5-16.

Park, E., Kim, H., Kim, J. M., Primack, B., Vidal-Cardenas, S., Xu, Y., Price, B. D., Mills, A. A. , D’Andrea, A. D. (2013) FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis. Molecular Cell, 50(6) pp. 908-918.

Vernersson Lindahl, E., Garcia, E. L. , Mills, A. A. (2013) An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome. American Journal of Medical Genetics Part A, 161(8) pp. 1961-1971.

Paul, S., Kuo, A., Schalch, T., Vogel, H., Joshua-Tor, L., McCombie, W. R., Gozani, O., Hammell, M. , Mills, A. A. (2013) Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression. Cell Reports, 3(1) pp. 92-102.

Kerr, J. B., Hutt, K. J, Michalak, E. M., Cook, M., Vandenberg, C. J., Liew, S. H., Bouillet, P., Mills, A., Scott, C. L., Findlay, J. K. , Strasser, A. (2012) DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa. Molecular Cell, 48(3) pp. 343-352.

Horev, G., Ellegood, J., Lerch, J. P., Son, Y. E., Muthuswamy, L., Vogel, H., Krieger, A. M., Buja, A., Henkelman, R. M., Wigler, M. H. , Mills, A. A. (2011) Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proceedings of the National Academy of Sciences of the United States of America, 108(41) pp. 17076-81.

Keyes, W. M., Pecoraro, M., Aranda, V., Vernersson-Lindahl, E., Li, W., Vogel, H., Guo, X., Garcia, E. L., Michurina, T. V., Enikolopov, G. N., Muthuswamy, S. K. , Mills, A. A. (2011) DeltaNp63alpha Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis. Cell Stem Cell, 8(2) pp. 164-76.

Mills, A. A. (2010) Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer, 10(10) pp. 669-82.

Moretti, F., Marinari, B., Iacono, N. L., Botti, E., Giunta, A., Spallone, G., Garaffo, G., Vernersson-Lindahl, E., Merlo, G., Mills, A. A., Ballaro, C., Alema, S., Chimenti, S., Guerrini, L. , Costanzo, A. (2010) A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. Journal of Clinical Investigation, 120(5) pp. 1570-1577.

Moretti, F., Spallone, G., Botti, E., Giunta, A., Lo Iacono, N., Merlo, G., Mills, A. A., Alema, S., Chimenti, S., Guerrini, L. , Costanzo, A. (2010) p63 and IRF6 are components of a common molecular pathway disrupted in ectodermal dysplasias. Journal of Investigative Dermatology, 130 pp. 626.

Vernersson-Lindahl, E. , Mills, A. A. (2010) ΔNp73β puts the brakes on DNA repair. Genes Dev, 24(6) pp. 517-20.

Guo, X., Keyes, W. M., Papazoglu, C., Zuber, J., Li, W., Lowe, S. W., Vogel, H. , Mills, A. A. (2009) TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol, 11(12) pp. 1451–1457.

Boles, M. K., Wilkinson, B. M., Maxwell, A., Lai, L., Mills, A. A., Nishijima, I., Salinger, A. P., Moskowitz, I., Hirschi, K. K., Liu, B., Bradley, A. , Justice, M. J. (2009) A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet, 10(1) pp. 12.

Stark, K. L., Xu, B., Bagchi, A., Lai, W. S., Liu, H., Hsu, R., Wan, X., Pavlidis, P., Mills, A. A., Karayiorgou, M. , Gogos, J. A. (2008) Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet, 40(6) pp. 751-760.

Bagchi, A. , Mills, A. A. (2008) The quest for the 1p36 tumor suppressor. Cancer Res, 68(8) pp. 2551-6.

Lo Iacono, N., Mantero, S., Chiarelli, A., Garcia, E. L., Mills, A. A., Morasso, M. I., Costanzo, A., Levi, G., Guerrini, L. , Merlo, G. R. (2008) Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development, 135(7) pp. 1377-1388.

Suzuki, K., Haraguchi, R., Ogata, T., Barbieri, O., Alegria, O., Vieux-Rochas, M., Nakagata, N., Ito, M., Mills, A. A., Kurita, T., Levi, G. , Yamada, G. (2008) Abnormal urethra formation in mouse models of Split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet, 16(1) pp. 36-44.

Mignone, J. L., Roig-Lopez, J. L., Fedtsova, N., Schones, D. E., Manganas, L. N., Maletic-Savatic, M., Keyes, W. M., Mills, A. A., Gleiberman, A., Zhang, M. Q. , Enikolopov, G. N. (2007) Neural Potential of a Stem Cell Population in the Hair Follicle. Cell Cycle, 6(17) pp. 2161 - 2170 .

Guo, X. C. , Mills, A. A. (2007) p63, cellular senescence and tumor development. Cell Cycle, 6(3) pp. 305-11.

Papazoglu, C. , Mills, A. A. (2007) p53: At the crossroad between cancer and ageing. Journal of Pathology, 211(2) pp. 124-133.

Bagchi, A., Papazoglu, C., Wu, Y., Capurso, D., Brodt, M., Francis, D., Bredel, M., Vogel, H. , Mills, A. A. (2007) CHD5 Is a Tumor Suppressor at Human 1p36. Cell, 128(3) pp. 459-475.

Carroll, D. K., Carroll, J. S., Leong, C. O., Cheng, F., Brown, M., Mills, A. A., Brugge, J. S. , Ellisen, L. W. (2006) p63 regulates an adhesion programme and cell survival in epithelial cells. Nature Cell Biology, 8(6) pp. 551-561.

Keyes, W. M., Vogel, H., Koster, M. I., Guo, X., Qi, Y., Petherbridge, K. M., Roop, D. R., Bradley, A. , Mills, A. A. (2006) p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A, 103(22) pp. 8435-40.

Keyes, W. M. , Mills, A. A. (2006) p63: a new link between senescence and aging. Cell Cycle, 5(3) pp. 260-265.

Mills, A. A. (2006) p63: oncogene or tumor suppressor?. Curr Opin Genet Dev, 16(1) pp. 38-44.

Laurikkala, J., Mikkola, M. L., James, M., Tummers, M., Mills, A. A. , Thesleff, I. (2006) p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development, 133(8) pp. 1553-1563.

Jacobs, W. B., Govoni, G., Ho, D., Atwal, J. K., Barnabe-Heider, F., Keyes, W. M., Mills, A. A., Miller, F. D. , Kaplan, D. R. (2005) p63 is an essential proapoptotic protein during neural development. Neuron, 48(5) pp. 743-756.

Mills, A. A. (2005) p53: link to the past, bridge to the future. Genes Dev, 19(18) pp. 2091-9.

Keyes, William M., Wu, Ying, Vogel, Hannes, Guo, Xuecui, Lowe, Scott W. , Mills, Alea A. (2005) p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev, 19(17) pp. 1986-99.

Kurita, T., Cunha, G. R., Robboy, S. J., Mills, A. A. , Medina, R. T. (2005) Differential expression of p63 isoforms in female reproductive organs. Mechanisms of Development, 122(9) pp. 1043-1055.

Ihrie, R. A., Marques, M. R., Nguyen, B. T., Horner, J. S., Papazoglu, C., Bronson, R. T., Mills, A. A. , Attardi, L. D. (2005) Perp is a p63-regulated gene essential for epithelial integrity. Cell, 120(6) pp. 843-856.

Kurita, T., Medina, R. T., Mills, A. A. , Cunha, G. R. (2004) Role of p63 and basal cells in the prostate. Development, 131(20) pp. 4955-4964.

Kurita, T., Mills, A. A. , Cunha, G. R. (2004) Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis. Development, 131(7) pp. 1639-1649.

Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J. , Roop, D. R. (2004) p63 is the molecular switch for initiation of an epithelial stratification program. Genes & Development, 18(2) pp. 126-131.

Nishijima, I., Mills, A., Qi, Y., Mills, M. , Bradley, A. (2003) Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis, 36(3) pp. 142-148.

Keyes, W. M. , Mills, A. A. (2003) Inducible systems see the light. Trends in Biotechnology, 21(2) pp. 53-55.

Bernstein, E., Kim, S. Y., Carmell, M. A., Murchison, E. P., Alcorn, H., Li, M. Z., Mills, A. A., Elledge, S. J., Anderson, K. V. , Hannon, G. J. (2003) Dicer is essential for mouse development. Nature Genetics, 35(3) pp. 215-217.

Garcia, E. L. , Mills, A. A. (2002) Getting around lethality with inducible Cre-mediated excision. Seminars in Cell & Developmental Biology, 13(2) pp. 151-158.

Mills, A. (2002) Conducting the exploration of gene function. Seminars in Cell & Developmental Biology, 13(2) pp. 107-107.

Mills, A. A., Qi, Y. , Bradley, A. (2002) Conditional inactivation of p63 by Cre-mediated excision. Genesis, 32(2) pp. 138-141.

Su, H., Mills, A. A., Wang, X. Z. , Bradley, A. (2002) A targeted X-linked CMV-Cre line. Genesis, 32(2) pp. 187-188.

Mills, A. A. (2001) Changing colors in mice: an inducible system that delivers. Genes & Development, 15(12) pp. 1461-1467.

Mills, A. A. , Bradley, A. (2001) From mouse to man: generating megabase chromosome rearrangements. Trends in Genetics, 17(6) pp. 331-339.

Zheng, B., Mills, A. A. , Bradley, A. (2001) Introducing defined chromosomal rearrangements into the mouse genome. Methods, 24(1) pp. 81-94.

Mills, A. A., Mills, M. J., Gardiner, D. M., Bryant, S. V. , Stanbridge, E. J. (1999) Analysis of the pattern of QM expression during mouse development. Differentiation, 64(3) pp. 161-171.

Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R. , Bradley, A. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature, 398(6729) pp. 708-713.

Zheng, B., Mills, A. A. , Bradley, A. (1999) A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Research, 27(11) pp. 2354-2360.

Nguyen, Y. H., Mills, A. A. , Stanbridge, E. J. (1998) Assembly of the QM protein onto the 60S ribosomal subunit occurs in the cytoplasm. Journal of Cellular Biochemistry, 68(2) pp. 281-285.

Farmer, A. A., Loftus, T. M., Mills, A. A., Sato, K. Y., Neill, J. D., Tron, T., Yang, M., Trumpower, B. L. , Stanbridge, E. J. (1994) Extreme evolutionary conservation of QM, a novel c-Jun associated transcription factor. Human Molecular Genetics, 3(5) pp. 723-728.

Stanbridge, E., Farmer, A., Mills, A., Loftus, T., Kongkasuriyachai, D., Dowdy, S. , Weissman, B. (1994) Molecular characterization of QM, a novel gene with properties consistent with tumor suppressor function. Cold Spring Harbor Symposia on Quantitative Biology, 59 pp. 573-576.

Harth, G., Andrews, N., Mills, A. A., Engel, J. C., Smith, R. , McKerrow, J. H. (1993) Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. Molecular and Biochemical Parasitology, 58(1) pp. 17-24.

Eakin, A. E., Mills, A. A., Harth, G., McKerrow, J. H. , Craik, C. S. (1992) The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi. Journal of Biological Chemistry, 267(11) pp. 7411-7420.