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Safaric Tepes, Polona, Pal, Debjani, Lindsted, Trine, Ibarra, Ingrid, Lujambio, Amaia, Jimenez Sabinina, Vilma, Senturk, Serif, Miller, Madison, Korimerla, Navya, Huang, Jiahao, Glassman, Lawrence, Lee, Paul, Zeltsman, David, Hyman, Kevin, Esposito, Michael, Hannon, Greg , Sordella, Raffaella (2021) An epigenetic switch regulates the ontogeny of AXL positive/EGFR-TKI resistant cells by modulating miR-335 expression. eLife, 10

Dokshin, G. A., Davis, G. M., Sawle, A. D., Eldridge, M. D., Nicholls, P. K., Gourley, T. E., Romer, K. A., Molesworth, L. W., Tatnell, H. R., Ozturk, A. R., de Rooij, D. G., Hannon, G. J., Page, D. C., Mello, C. C. , Carmell, M. A. (2019) GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. Dev Cell,

Kneuss, E., Munafo, M., Eastwood, E. L., Deumer, U. S., Preall, J. B., Hannon, G. J. , Czech, B. (2019) Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export. Genes Dev, 33(17-18) pp. 1208-1220.

Delas, M. J., Jackson, B. T., Kovacevic, T., Vangelisti, S., Munera Maravilla, E., Wild, S. A., Stork, E. M., Erard, N., Knott, S. R. V. , Hannon, G. J. (2019) lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation. Cell Rep, 27(3) pp. 719-729.e6.

Sonzogni, O., Haynes, J., Seifried, L. A., Kamel, Y. M., Huang, K., BeGora, M. D., Yeung, F. A., Robert-Tissot, C., Heng, Y. J., Yuan, X., Wulf, G. M., Kron, K. J., Wagenblast, E., Lupien, M., Kislinger, T., Hannon, G. J. , Muthuswamy, S. K. (2018) Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo. PLoS Biol, 16(6) pp. e2004049.

Xie, Y., Cao, Z., Wong, E. W., Guan, Y., Ma, W., Zhang, J. Q., Walczak, E. G., Murphy, D., Ran, L., Sirota, I., Wang, S., Shukla, S., Gao, D., Knott, S. R., Chang, K., Leu, J., Wongvipat, J., Antonescu, C. R., Hannon, G., Chi, P. , Chen, Y. (2018) COP1-DET1-ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. J Clin Invest, 128(4) pp. 1442-1457.

Xie, Y., Cao, Z., Wong, E. W., Guan, Y., Ma, W., Zhang, J. Q., Walczak, E. G., Murphy, D., Ran, L., Sirota, I., Wang, S., Shukla, S., Gao, D., Knott, S. R., Chang, K., Leu, J., Wongvipat, J., Antonescu, C. R., Hannon, G., Chi, P. , Chen, Y. (2018) COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. J Clin Invest, 128(4) pp. 1442-1457.

Knott, S. R. V., Wagenblast, E., Khan, S., Kim, S. Y., Soto, M., Wagner, M., Turgeon, M. O., Fish, L., Erard, N., Gable, A. L., Maceli, A. R., Dickopf, S., Papachristou, E. K., D'Santos, C. S., Carey, L. A., Wilkinson, J. E., Harrell, J. C., Perou, C. M., Goodarzi, H., Poulogiannis, G. , Hannon, G. J. (2018) Asparagine bioavailability governs metastasis in a model of breast cancer. Nature, 554(7692) pp. 378-381.

Qu, J., Hodges, E., Molaro, A., Gagneux, P., Dean, M. D., Hannon, G. J. , Smith, A. D. (2018) Evolutionary expansion of DNA hypomethylation in the mammalian germline genome. Genome Research, 28(2) pp. 145-158.

Xie, Y. Y., Cao, Z., Wong, W. P., Guan, Y. X., Zhang, J., Walczak, E., Murphy, D., Ran, L., Sirota, I., Wang, S. Q., Shukla, S., Gao, D., Wongvipat, J., Knott, S., Chang, K., Antonescu, C., Hannon, G., Chi, P. , Chen, Y. (2018) COP1-ETS axis regulates ERK transcriptional output and modulates sensitivity to MAPK inhibitors. Clinical Cancer Research, 24(2 Supp) pp. 61-61.

Delas, M. J., Sabin, L. R., Dolzhenko, E., Knott, S. R., Munera Maravilla, E., Jackson, B. T., Wild, S. A., Kovacevic, T., Stork, E. M., Zhou, M., Erard, N., Lee, E., Kelley, D. R., Roth, M., Barbosa, I. S. A., Zuber, J., Rinn, J. L., Smith, A. D. , Hannon, G. J. (2017) lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. Elife, 6 pp. e25607.

Frey, W. D., Chaudhry, A., Slepicka, P. F., Ouellette, A. M., Kirberger, S. E., Pomerantz, W. C. K., Hannon, G. J. , Dos Santos, C. O. (2017) BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells. Stem Cell Reports, 9(1) pp. 23-31.

Delas, M. J. , Hannon, G. J. (2017) lncRNAs in development and disease: from functions to mechanisms. Open Biol, 7(7)

Pal, D., Pertot, A., Shirole, N. H., Yao, Z., Anaparthy, N., Garvin, T., Cox, H., Chang, K., Rollins, F., Kendall, J., Edwards, L., Singh, V. A., Stone, G. C., Schatz, M. C., Hicks, J., Hannon, G. , Sordella, R. (2017) TGF-beta reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells. Elife, 6

Erard, Nicolas, Knott, Simon R. V. , Hannon, Gregory J. (2017) A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout. Molecular Cell, 67(2) pp. 348-354.e3.

McFadden, D. G., Politi, K., Bhutkar, A., Chen, F. K., Song, X., Pirun, M., Santiago, P. M., Kim-Kiselak, C., Platt, J. T., Lee, E., Hodges, E., Rosebrock, A. P., Bronson, R. T., Socci, N. D., Hannon, G. J., Jacks, T. , Varmus, H. (2016) Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma. Proc Natl Acad Sci U S A, 113(42) pp. E6409-E6417.

Fagegaltier, D., Falciatori, I., Czech, B., Castel, S., Perrimon, N., Simcox, A. , Hannon, G. J. (2016) Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway. Genes Dev, 30(14) pp. 1623-35.

Hammell, Christopher M , Hannon, Gregory J (2016) Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA.. Cold Spring Harbor protocols, 2016(1) pp. pdb.prot086306.

Sanchez, Carlos G, Teixeira, Felipe Karam, Czech, Benjamin, Preall, Jonathan B, Zamparini, Andrea L, Seifert, Jessica R K., Malone, Colin D, Hannon, Gregory J , Lehmann, Ruth (2015) Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Cell Stem Cell, 18(2) pp. 276-290.

Zhou, X., Battistoni, G., El Demerdash, O., Gurtowski, J., Wunderer, J., Falciatori, I., Ladurner, P., Schatz, M. C., Hannon, G. J. , Wasik, K. A. (2015) Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano. RNA, 21(11) pp. 1885-1897.

Yu, Y., Gu, J., Jin, Y., Luo, Y., Preall, J. B., Ma, J., Czech, B. , Hannon, G. J. (2015) Panoramix enforces piRNA-dependent cotranscriptional silencing. Science, 350(6258) pp. 339-42.

Dequeant, M. L., Fagegaltier, D., Hu, Y., Spirohn, K., Simcox, A., Hannon, G. J. , Perrimon, N. (2015) Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization. Proc Natl Acad Sci U S A, 112(42) pp. 12974-12979.

Wasik, K., Gurtowski, J., Zhou, X., Ramos, O. M., Delas, M. J., Battistoni, G., El Demerdash, O., Falciatori, I., Vizoso, D. B., Smith, A. D., Ladurner, P., Scharer, L., McCombie, W. R., Hannon, G. J. , Schatz, M. (2015) Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano. Proc Natl Acad Sci U S A, 112(40) pp. 12462-12467.

Wasik, K. A., Tam, O. H., Knott, S. R., Falciatori, I., Hammell, M., Vagin, V. V. , Hannon, G. J. (2015) RNF17 blocks promiscuous activity of PIWI proteins in mouse testes. Genes Dev, 29(13) pp. 1403-1415.

Goh, W. S., Falciatori, I., Tam, O. H., Burgess, R., Meikar, O., Kotaja, N., Hammell, M. , Hannon, G. J. (2015) piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis. Genes Dev, 29(10) pp. 1032-44.

Dos Santos, C. O., Dolzhenko, E., Hodges, E., Smith, A. D. , Hannon, G. J. (2015) An Epigenetic Memory of Pregnancy in the Mouse Mammary Gland. Cell Reports,

Teixeira, F. K., Sanchez, C. G., Hurd, T. R., Seifert, J. R., Czech, B., Preall, J. B., Hannon, G. J. , Lehmann, R. (2015) ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. Nature Cell Biology, 17(5) pp. 689-696.

Wagenblast, E., Soto, M., Gutierrez-Angel, S., Hartl, C. A., Gable, A. L., Maceli, A. R., Erard, N., Williams, A. M., Kim, S. Y., Dickopf, S., Harrell, J. C., Smith, A. D., Perou, C. M., Wilkinson, J. E., Hannon, G. J. , Knott, S. R. (2015) A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis. Nature, 520(7547) pp. 358-362.

Marinov, Georgi K, Wang, Jie, Handler, Dominik, Wold, Barbara J, Weng, Zhiping, Hannon, Gregory J, Aravin, Alexei A, Zamore, Phillip D, Brennecke, Julius , Toth, Katalin Fejes (2015) Pitfalls of Mapping High-Throughput Sequencing Data to Repetitive Sequences: Piwi’s Genomic Targets Still Not Identified. Developmental Cell, 32(6) pp. 765-771.

Stein, P., Rozhkov, N. V., Li, F., Cardenas, F. L., Davydenk, O., Vandivier, L. E., Gregory, B. D., Hannon, G. J. , Schultz, R. M. (2015) Essential Role for Endogenous siRNAs during Meiosis in Mouse Oocytes. PLoS Genetics, 11(2) pp. e1005013.

Knott, S. R., Maceli, A. R., Erard, N., Chang, K., Marran, K., Zhou, X., Gordon, A., El Demerdash, O., Wagenblast, E., Kim, S., Fellmann, C. , Hannon, G. J. (2014) A Computational Algorithm to Predict shRNA Potency. Mol Cell, 56(6) pp. 796-807.

Malaspinas, Anna-Sapfo, Lao, Oscar, Schroeder, Hannes, Rasmussen, Morten, Raghavan, Maanasa, Moltke, Ida, Campos, Paula F., Sagredo, Francisca Santana, Rasmussen, Simon, Gonçalves, Vanessa F., Albrechtsen, Anders, Allentoft, Morten E., Johnson, Philip L. F., Li, Mingkun, Reis, Silvia, Bernardo, Danilo V., DeGiorgio, Michael, Duggan, Ana T., Bastos, Murilo, Wang, Yong, Stenderup, Jesper, Moreno-Mayar, J. Victor, Brunak, Søren, Sicheritz-Ponten, Thomas, Hodges, Emily, Hannon, Gregory J., Orlando, Ludovic, Price, T. Douglas, Jensen, Jeffrey D., Nielsen, Rasmus, Heinemeier, Jan, Olsen, Jesper, Rodrigues-Carvalho, Claudia, Lahr, Marta Mirazón, Neves, Walter A., Kayser, Manfred, Higham, Thomas, Stoneking, Mark, Pena, Sergio D. J. , Willerslev, Eske (2014) Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil. Current Biology, 24(21) pp. R1035-R1037.

Premsrirut, P. K., Yoon, B., Pesic, M., Dow, L. E., Zuber, J., Lowe, S. W., Hannon, G. J., Zender, L. , Fellmann, C. (2014) RNAi mouse models: Revolutionizing drug discovery in vivo. Cancer Research, 74(19) pp. Abstract#2974.

Deng, L., Shang, L., Bai, S., Chen, J., He, X., Trevino, R. M., Chen, S., Li, X., Meng, X., Yu, B., Wang, X., Liu, Y., McDermott, S. P., Ariazi, A. E., Ginestier, C., Ibarra, I., Ke, J., Luther, T. K., Clouthier, S. G., Xu, L., Shan, G., Song, E., Yao, H., Hannon, G. J., Weiss, S. J., Wicha, M. S. , Liu, S. (2014) microRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development. Cancer Res, 74(22) pp. 6648-6660.

Yang, M., Haase, A. D., Huang, F. K., Coulis, G., Rivera, K. D., Dickinson, B. C., Chang, C. J., Pappin, D. J., Neubert, T. A., Hannon, G. J., Boivin, B. , Tonks, N. K. (2014) Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence. Mol Cell, 55(5) pp. 782-790.

Fagegaltier, D., Konig, A., Gordon, A., Lai, E. C., Gingeras, T. R., Hannon, G. J. , Shcherbata, H. R. (2014) A Genome-Wide Survey of Sexually Dimorphic Expression of Drosophila miRNAs Identifies the Steroid Hormone-Induced miRNA let-7 as a Regulator of Sexual Identity. Genetics, 198(2) pp. 647-668.

Molaro, A., Falciatori, I., Hodges, E., Aravin, A. A., Marran, K., Rafii, S., McCombie, W. R., Smith, A. D. , Hannon, G. J. (2014) Two waves of de novo methylation during mouse germ cell development. Genes and Development, 28(14) pp. 1544-9.

Rechavi, Oded, Houri-Ze’evi, Leah, Anava, Sarit, Goh, Wee Siong Sho, Kerk, Sze Yen, Hannon, Gregory J , Hobert, Oliver (2014) Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans. Cell, 158(2) pp. 277-287.

Goh, W. S. S., Seah, J. W. E., Harrison, E. J., Chen, C., Hammell, C. M. , Hannon, G. J. (2014) A genome-wide RNAi screen identifies factors required for distinct stages of C-elegans piRNA biogenesis. Genes & Development, 28(7) pp. 797-807.

Meikar, O., Vagin, V. V., Chalmel, F., Sostar, K., Lardenois, A., Hammell, M., Jin, Y., Da Ros, M., Wasik, K. A., Toppari, J., Hannon, G. J. , Kotaja, N. (2014) An atlas of chromatoid body components. RNA, 20(4) pp. 483-95.

Faehnle, C. R., Elkayam, E., Haase, A. D., Hannon, G. J. , Joshua-Tor, L. (2014) Slicer and the Argonautes. Biophysical Journal, 106(2; Sup) pp. 455A-455A.

Chang, K., Marran, K., Valentine, A. , Hannon, G. J. (2014) Generation of transgenic drosophila expressing shRNAs in the miR-1 backbone. Cold Spring Harbor Protocols, 2014(5) pp. 501-509.

Siolas, D. , Hannon, G. J. (2013) Patient-derived tumor xenografts: Transforming clinical samples into mouse models. Cancer Research, 73(17) pp. 5315-5319.

Hauser, F., Chen, W. X., Deinlein, U., Chang, K., Ossowski, S., Fitz, J., Hannon, G. J. , Schroeder, J. I. (2013) A Genomic-Scale Artificial MicroRNA Library as a Tool to Investigate the Functionally Redundant Gene Space in Arabidopsis. Plant Cell, 25(8) pp. 2848-2863.

Karginov, F. V. , Hannon, G. J. (2013) Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. Genes and Development, 27(14) pp. 1624-32.

Schlesinger, F., Smith, A. D., Gingeras, T. R., Hannon, G. J. , Hodges, E. (2013) De novo DNA demethylation and non-coding transcription define active intergenic regulatory elements. Genome Research, 23(10) pp. 1601-1614.

Vagin, V. V., Yu, Y., Jankowska, A., Luo, Y., Wasik, K. A., Malone, C. D., Harrison, E., Rosebrock, A., Wakimoto, B. T., Fagegaltier, D., Muerdter, F. , Hannon, G. J. (2013) Minotaur is critical for primary piRNA biogenesis. RNA, 19(8) pp. 1064-1077.

Faehnle, Christopher R, Elkayam, Elad, Haase, Astrid D, Hannon, Gregory J , Joshua-Tor, Leemor (2013) The Making of a Slicer: Activation of Human Argonaute-1. Cell Reports, 3(6) pp. 1901-1909.

Raddatz, G., Guzzardo, P. M., Olova, N., Fantappié, M. R., Rampp, M., Schaefer, M., Reik, W., Hannon, G. J. , Lyko, F. (2013) Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proceedings of the National Academy of Sciences of the United States of America, 110(21) pp. 8627-8631.

Muerdter, F., Guzzardo, P. M., Gillis, J., Luo, Y., Yu, Y., Chen, C., Fekete, R. , Hannon, G.J. (2013) A Genome-wide RNAi Screen Draws a Genetic Framework for Transposon Control and Primary piRNA Biogenesis in Drosophila. Molecular Cell, 50(5) pp. 736-748.

Wiggs, J. L., Howell, G. R., Linkroum, K., Abdrabou, W., Hodges, E., Braine, C. E., Pasquale, L. R., Hannon, G. J., Haines, J. L. , John, S. W. M. (2013) Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma. Clinical Genetics, 84(2) pp. 167.

Lu, X. W., Wontakal, S. N., Kavi, H., Kim, B. J., Guzzardo, P. M., Emelyanov, A. V., Xu, N., Hannon, G. J., Zavadil, J., Fyodorov, D. V. , Skoultchi, A. I. (2013) Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9. Science, 340(6128) pp. 78-81.

Sabin, L. R., Delas, M. J. , Hannon, G. J. (2013) Dogma derailed: the many influences of RNA on the genome. Molecular Cell, 49(5) pp. 783-94.

Rozhkov, N. V., Hammell, M. , Hannon, G. J. (2013) Multiple roles for Piwi in silencing Drosophila transposons. Genes and Development, 27(4) pp. 400-412.

Sabin, L. R., Zheng, Q., Thekkat, P., Yang, J., Hannon, G. J., Gregory, B. D., Tudor, M. , Cherry, S. (2013) Dicer-2 Processes Diverse Viral RNA Species. PLoS ONE, 8(2)

Guzzardo, P. M., Muerdter, F. , Hannon, G. J. (2013) The piRNA pathway in flies: highlights and future directions. Curr Opin Genet Dev, 23(1) pp. 44-52.

Chang, K., Marran, K., Valentine, A. , Hannon, G. J. (2013) Creating an miR30-based shRNA vector. Cold Spring Harbor Protocols, 8(7) pp. 631-635.

Chang, K., Marran, K., Valentine, A. , Hannon, G. J. (2013) Infection of mammalian cells with retroviral shRNAs. Cold Spring Harbor Protocols, 2013(8) pp. 732-733.

Chang, K., Marran, K., Valentine, A. , Hannon, G. J. (2013) Packaging shRNA retroviruses. Cold Spring Harbor Protocols, 2013(8) pp. 734-737.

Czech, Benjamin, Preall, Jonathan B, McGinn, Jon , Hannon, Gregory J (2013) A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA Pathway. Molecular Cell, 50(5) pp. 749-761.

Dos Santos, C. O., Rebbeck, C., Rozhkova, E., Valentine, A., Samuels, A., Kadiri, L. R., Osten, P., Harris, E. Y., Uren, P. J., Smith, A. D. , Hannon, G. J. (2013) Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells. Proceedings of the National Academy of Sciences of the United States of America, 110(18) pp. 7123-7130.

Kaaij, L. T. J., van de Wetering, M., Fang, F., Decato, B., Molaro, A., van de Werken, H. J. G., van Es, J. H., Schuijers, J., de Wit, E., de Laat, W., Hannon, G. J., Clevers, H. C., Smith, A. D. , Ketting, R. F. (2013) DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biology, 14(5)

Hammell, C. M. , Hannon, G. J. (2012) Inducing RNAi in C. elegans by Feeding with dsRNA-expressing E. coli. Cold Spring Harb Protoc, 2012(12)

Djebali, S., Davis, C. A., Merkel, A., Dobin, A., Lassmann, T., Mortazavi, A., Tanzer, A., Lagarde, J., Lin, W., Schlesinger, F., Xue, C., Marinov, G. K., Khatun, J., Williams, B. A., Zaleski, C., Rozowsky, J., Röder, M., Kokocinski, F., Abdelhamid, R. F., Alioto, T., Antoshechkin, I., Baer, M. T., Bar, N. S., Batut, P., Bell, K., Bell, I., Chakrabortty, S., Chen, X., Chrast, J., Curado, J., Derrien, T., Drenkow, J., Dumais, E., Dumais, J., Duttagupta, R., Falconnet, E., Fastuca, M., Fejes-Toth, K., Ferreira, P., Foissac, S., Fullwood, M. J., Gao, H., Gonzalez, D., Gordon, A., Gunawardena, H., Howald, C., Jha, S., Johnson, R., Kapranov, P., King, B., Kingswood, C., Luo, O. J., Park, E., Persaud, K., Preall, J. B., Ribeca, P., Risk, B., Robyr, D., Sammeth, M., Schaffer, L., See, L. H., Shahab, A., Skancke, J., Suzuki, A. M., Takahashi, H., Tilgner, H., Trout, D., Walters, N., Wang, H., Wrobel, J., Yu, Y., Ruan, X., Hayashizaki, Y., Harrow, J., Gerstein, M., Hubbard, T., Reymond, A., Antonarakis, S. E., Hannon, G., Giddings, M. C., Ruan, Y., Wold, B., Carninci, P., Guig, R. , Gingeras, T. R. (2012) Landscape of transcription in human cells. Nature, 489(7414) pp. 101-108.

Dunham, I., Kundaje, A., Aldred, S. F., Collins, P. J., Davis, C., Doyle, F., Epstein, C. B., Frietze, S., Harrow, J., Kaul, R., Khatun, J., Lajoie, B. R., Landt, S. G., Lee, B. K., Pauli, F., Rosenbloom, K. R., Sabo, P., Safi, A., Sanyal, A., Shoresh, N., Simon, J. M., Song, L., Trinklein, N. D., Altshuler, R. C., Birney, E., Brown, J. B., Cheng, C., Djebali, S., Dong, X. J., Ernst, J., Furey, T. S., Gerstein, M., Giardine, B., Greven, M., Hardison, R. C., Harris, R. S., Herrero, J., Hoffman, M. M., Iyer, S., Kellis, M., Kheradpour, P., Lassmann, T., Li, Q. H., Lin, X., Marinov, G. K., Merkel, A., Mortazavi, A., Parker, S. C. J., Reddy, T. E., Rozowsky, J., Schlesinger, F., Thurman, R. E., Wang, J., Ward, L. D., Whitfield, T. W., Wilder, S. P., Wu, W., Xi, H. L. S., Yip, K. Y., Zhuang, J. L., Bernstein, B. E., Green, E. D., Gunter, C., Snyder, M., Pazin, M. J., Lowdon, R. F., Dillon, L. A. L., Adams, L. B., Kelly, C. J., Zhang, J., Wexler, J. R., Good, P. J., Feingold, E. A., Crawford, G. E., Dekker, J., Elnitski, L., Farnham, P. J., Giddings, M. C., Gingeras, T. R., Guigo, R., Hubbard, T. J., Kent, W. J., Lieb, J. D., Margulies, E. H., Myers, R. M., Stamatoyannopoulos, J. A., Tenenbaum, S. A., Weng, Z. P., White, K. P., Wold, B., Yu, Y., Wrobel, J., Risk, B. A., Gunawardena, H. P., Kuiper, H. C., Maier, C. W., Xie, L., Chen, X., Mikkelsen, T. S. , Gillespie, S. (2012) An integrated encyclopedia of DNA elements in the human genome. Nature, 489(7414) pp. 57-74.

Tessanne, K., Golding, M. C., Long, C. R., Peoples, M. D., Hannon, G. , Westhusin, M. E. (2012) Production of transgenic calves expressing an shRNA targeting myostatin. Molecular Reproduction and Development, 79(3) pp. 176-185.

He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J. , Huang, Z. J. (2012) Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain. Neuron, 73(1) pp. 35-48.

Muerdter, F., Olovnikov, I., Molaro, A., Rozhkov, N. V., Czech, B., Gordon, A., Hannon, G. J. , Aravin, A. A. (2012) Production of artificial piRNAs in flies and mice. RNA, 18(1) pp. 42-52.

Bender, H. S., Murchison, E. P., Pickett, H. A., Deakin, J. E., Strong, M. A., Conlan, C., McMillan, D. A., Neumann, A. A., Greider, C. W., Hannon, G. J., Reddel, R. R. , Graves, J. A. M. (2012) Extreme Telomere Length Dimorphism in the Tasmanian Devil and Related Marsupials Suggests Parental Control of Telomere Length. PLoS One, 7(9)

Chang, K., Marran, K., Valentine, A. , Hannon, G. J. (2012) RNAi in cultured mammalian cells using synthetic siRNAs. Cold Spring Harbor Protocols, 7(9) pp. 957-961.

Chi, S. W., Hannon, G. J. , Darnell, R. B. (2012) An alternative mode of microRNA target recognition. Nature Structural and Molecular Biology, 19(3) pp. 321-327.

Dahlman, K. B., Parker, J. S., Shamu, T., Hieronymus, H., Chapinski, C., Carver, B., Chang, K., Hannon, G. J. , Sawyers, C. L. (2012) Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening. PLoS One, 7(4)

Dow, L. E., Premsrirut, P. K., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, R. A., Hannon, G. J. , Lowe, S. W. (2012) A pipeline for the generation of shRNA transgenic mice. Nature Protocols, 7(2) pp. 374-393.

Elkayam, E., Kuhn, C. D., Tocilj, A., Haase, A. D., Greene, E. M., Hannon, G. J. , Joshua-Tor, L. (2012) The structure of human argonaute-2 in complex with miR-20a. Cell, 150(1) pp. 100-110.

Fang, F., Hodges, E., Molaro, A., Dean, M., Hannon, G. J. , Smith, A. D. (2012) Genomic landscape of human allele-specific DNA methylation. Proceedings of the National Academy of Sciences of the United States of America, 109(19) pp. 7332-7337.

Ipsaro, J. J., Haase, A. D., Knott, S. R., Joshua-Tor, L. , Hannon, G. J. (2012) The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature, 491(7423) pp. 279-282.

Lindsay, J., Carone, D. M., Brown, J., Hall, L., Qureshi, S., Mitchell, S. E., Jannetty, N., Hannon, G., Renfree, M., Pask, A., O'Neill, M. , O'Neill, R. (2012) Unique small RNA signatures uncovered in the tammar wallaby genome. BMC Genomics, 13 pp. 559.

Liu, S., Patel, S. H., Ginestier, C., Ibarra, I., Martin-Trevino, R., Bai, S., McDermott, S. P., Shang, L., Ke, J., Ou, S. J., Heath, A., Zhang, K. J., Korkaya, H., Clouthier, S. G., Charafe-Jauffret, E., Birnbaum, D., Hannon, G. J. , Wicha, M. S. (2012) MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genetics, 8(6)

Preall, J. B., Czech, B., Guzzardo, P. M., Muerdter, F. , Hannon, G. J. (2012) Shutdown is a component of the Drosophila piRNA biogenesis machinery. RNA, 18(8) pp. 1446-1457.

Tan, X., Lu, Z. J., Gao, G., Xu, Q., Hu, L., Fellmann, C., Li, M. Z., Qu, H., Lowe, S. W., Hannon, G. J. , Elledge, S. J. (2012) Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. Proceedings of the National Academy of Sciences of the United States of America, 109(3) pp. 869-874.

Uren, P. J., Bahrami-Samani, E., Burns, S. C., Qiao, M., Karginov, F. V., Hodges, E., Hannon, G. J., Sanford, J. R., Penalva, L. O. F. , Smith, A. D. (2012) Site identification in high-throughput RNA-protein interaction data. Bioinformatics, 28(23) pp. 3013-3020.

Van Stry, M., Oguin Iii, T. H., Cheloufi, S., Vogel, P., Watanabe, M., Pillai, M. R., Dash, P., Thomas, P. G., Hannon, G. J. , Bix, M. (2012) Enhanced susceptibility of Ago1/3 double-null mice to influenza a virus infection. Journal of Virology, 86(8) pp. 4151-4157.

Liu-Sullivan, N., Zhang, J., Bakleh, A., Marchica, J., Li, J., Siolas, D., Laquerre, S., Degenhardt, Y. Y., Wooster, R., Chang, K., Hannon, G. J. , Powers, S. (2011) Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1). Oncotarget, 2(12) pp. 1254-64.

Joshua-Tor, L. , Hannon, G. J. (2011) Ancestral Roles of Small RNAs: An Ago-Centric Perspective. Cold Spring Harb Perspect Biol, 3(10)

Molaro, A., Hodges, E., Fang, F., Song, Q., McCombie, W. R., Hannon, G. J. , Smith, A. D. (2011) Sperm Methylation Profiles Reveal Features of Epigenetic Inheritance and Evolution in Primates. Cell, 146(6) pp. 1029-1041.

Albert, F. W., Hodges, E., Jensen, J. D., Besnier, F., Xuan, Z. Y., Rooks, M., Bhattacharjee, A., Brizuela, L., Good, J. M., Green, R. E., Burbano, H. A., Plyusnina, I. Z., Trut, L., Andersson, L., Schoneberg, T., Carlborg, O., Hannon, G. J. , Paabo, S. (2011) Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection. Heredity, 107(3) pp. 205-214.

Rangan, P., Malone, Colin D., Navarro, C., Newbold, S. P, Hayes, P. S, Sachidanandam, R., Hannon, G. J. , Lehmann, R. (2011) piRNA Production Requires Heterochromatin Formation in Drosophila. Current Biology, 21(16) pp. 1373-1379.

Erlich, Y., Edvardson, S., Hodges, E., Zenvirt, S., Thekkat, P., Shaag, A., Dor, T., Hannon, G. J. , Elpeleg, O. (2011) Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Research, 21(5) pp. 658-664.

Myers, R. M., Stamatoyannopoulos, J., Snyder, M., Dunham, I., Hardison, R. C., Bernstein, B. E., Gingeras, T. R., Kent, W. J., Birney, E., Wold, B., Crawford, G. E., Epstein, C. B., Shoresh, N., Ernst, J., Mikkelsen, T. S., Kheradpour, P., Zhang, X. L., Wang, L., Issner, R., Coyne, M. J., Durham, T., Ku, M. C., Truong, T., Ward, L. D., Altshuler, R. C., Lin, M. F., Kellis, M., Davis, C. A., Kapranov, P., Dobin, A., Zaleski, C., Schlesinger, F., Batut, P., Chakrabortty, S., Jha, S., Lin, W., Drenkow, J., Wang, H. E., Bell, K. G., Gao, H., Bell, I., Dumais, E., Dumais, J., Antonarakis, S. E., Ucla, C., Borel, C., Guigo, R., Djebali, S., Lagarde, J., Kingswood, C., Ribeca, P., Sammeth, M., Alioto, T., Merkel, A., Tilgner, H., Carninci, P., Hayashizaki, Y., Lassmann, T., Takahashi, H., Abdelhamid, R. F., Hannon, G., Fejes-Toth, K., Preall, J., Gordon, A., Sotirova, V., Reymond, A., Howald, C., Graison, E. A. Y., Chrast, J., Ruan, Y. J., Ruan, X. A., Shahab, A., Poh, W. T., Wei, C. L., Furey, T. S., Boyle, A. P., Sheffield, N. C., Song, L. Y., Shibata, Y., Vales, T., Winter, D., Zhang, Z. C., London, D., Wang, T. Y., Keefe, D., Iyer, V. R., Lee, B. K., McDaniell, R. M., Liu, Z., Battenhouse, A., Bhinge, A. A., Lieb, J. D., Grasfeder, L. L., Showers, K. A., Giresi, P. G., Kim, S. K. C., Shestak, C., Pauli, F., Reddy, T. E. , Gertz, J. (2011) A User's Guide to the Encyclopedia of DNA Elements (ENCODE). Plos Biology, 9(4)

Premsrirut, P. K., Dow, L. E., Kim, S. Y., Camiolo, M., Malone, C. D., Miething, C., Scuoppo, C., Zuber, J., Dickins, R. A., Kogan, Scott C, Shroyer, Kenneth R, Sordella, R., Hannon, G. J. , Lowe, S. W. (2011) A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference. Cell, 145(1) pp. 145-158.

Lachke, S. A., Alkuraya, F. S., Kneeland, S. C., Ohn, T., Aboukhalil, A., Howell, G. R., Saadi, I., Cavallesco, R., Yue, Y. Z., Tsai, A. C. H., Nair, K. S., Cosma, M. I., Smith, R. S., Hodges, E., AlFadhli, S. M., Al-Hajeri, A., Shamseldin, H. E., Behbehani, A., Hannon, G. J., Bulyk, M. L., Drack, A. V., Anderson, P. J., John, S. W. M. , Maas, R. L. (2011) Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma. Science, 331(6024) pp. 1571-1576.

Fellmann, C., Zuber, J., McJunkin, K., Chang, K., Malone, C. D., Dickins, R. A., Xu, Q., Hengartner, M. O., Elledge, S. J., Hannon, G. J. , Lowe, S. W. (2011) Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay. Molecular Cell, 41(6) pp. 733-746.

Bivona, T. G., Hieronymus, H., Parker, J., Chang, K., Taron, M., Rosell, R., Moonsamy, P., Dahlman, K., Miller, V. A., Costa, C., Hannon, G. J. , Sawyers, C. L. (2011) FAS and NF-kappa B signalling modulate dependence of lung cancers on mutant EGFR. Nature, 471(7339) pp. 523-526.

Berezikov, E., Robine, N., Samsonova, A., Westholm, J. O., Naqvi, A., Hung, J. H., Okamura, K., Dai, Q., Bortolamiol-Becet, D., Martin, R., Zhao, Y. J., Zamore, P. D., Hannon, G. J., Marra, M. A., Weng, Z. P., Perrimon, N. , Lai, E. C. (2011) Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Research, 21(2) pp. 203-215.

Czech, B. , Hannon, G. J. (2011) Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet, 12(1) pp. 19-31.

Zuber, J., McJunkin, K., Fellmann, C., Dow, L. E., Taylor, M. J., Hannon, G. J. , Lowe, S. W. (2011) Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNA. Nature Biotechnology, 29(1) pp. 79-85.

Choi, Y. J., Lin, C. P., Ho, J. J., He, X., Okada, N., Bu, P., Zhong, Y., Kim, S. Y., Bennett, M. J., Chen, C., Ozturk, A., Hicks, G. G., Hannon, G. J. , He, L. (2011) MiR-34 miRNAs provide a barrier for somatic cell reprogramming. Nature Cell Biology, 13(11) pp. 1353-1360.

Hodges, E., Molaro, A., Dos Santos, C. O., Thekkat, P., Song, Q., Uren, P. J., Park, J. H., Butler, J., Rafii, S., McCombie, W. R., Smith, A. D. , Hannon, G. J. (2011) Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment. Molecular Cell, 44(1) pp. 17-28.

Lee, S., Paulson, K. G., Murchison, E. P., Afanasiev, O. K., Alkan, C., Leonard, J. H., Byrd, D. R., Hannon, G. J. , Nghiem, P. (2011) Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas. Journal of Clinical Virology, 52(3) pp. 272-275.

Ni, J. Q., Zhou, R., Czech, B., Liu, L. P., Holderbaum, L., Yang-Zhou, D., Shim, H. S., Tao, R., Handler, D., Karpowicz, P., Binari, R., Booker, M., Brennecke, J., Perkins, L. A., Hannon, G. J. , Perrimon, N. (2011) A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nature Methods, 8(5) pp. 405-407.

Obad, S., Dos Santos, C. O., Petri, A., Heidenblad, M., Broom, O., Ruse, C., Fu, C., Lindow, M., Stenvang, J., Straarup, E. M., Hansen, H. F., Koch, T., Pappin, D., Hannon, G. J. , Kauppinen, S. (2011) Silencing of microRNA families by seed-targeting tiny LNAs. Nature Genetics, 43(4) pp. 371-380.

Spierings, D. C., McGoldrick, D., Hamilton-Easton, A. M., Neale, G., Murchison, E. P., Hannon, G. J., Green, D. R. , Withoff, S. (2011) Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage. Blood, 117(20) pp. 5340-5349.

Tanaka, T., Hosokawa, M., Vagin, V. V., Reuter, M., Hayashi, E., Mochizuki, A. L., Kitamura, K., Yamanaka, H., Kondoh, G., Okawa, K., Kuramochi-Miyagawa, S., Nakano, T., Sachidanandam, R., Hannon, G. J., Pillai, R. S., Nakatsuji, N. , Chuma, S. (2011) Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America, 108(26) pp. 10579-10584.

Wang, J., Czech, B., Crunk, A., Wallace, A., Mitreva, M., Hannon, G. J. , Davis, R. E. (2011) Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles. Genome Research, 21(9) pp. 1462-1477.

Zamparini, A. L., Davis, M. Y., Malone, C. D., Vieira, E., Zavadil, J., Sachidanandam, R., Hannon, G. J. , Lehmann, R. (2011) Vreteno, a gonad-specific protein, is essential for germline development and primary pirna biogenesis in Drosophila. Development, 138(18) pp. 4039-4050.

Haase, A. D., Fenoglio, S., Muerdter, F., Guzzardo, P. M., Czech, B., Pappin, D. J., Chen, C., Gordon, A. , Hannon, G. J. (2010) Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila. Genes and Development, 24(22) pp. 2499-2504.

Chong, M. M. W., Zhang, G. A., Cheloufi, S., Neubert, T. A., Hannon, G. J. , Littman, D. R. (2010) Canonical and alternate functions of the microRNA biogenesis machinery. Genes & Development, 24(17) pp. 1951-1960.

Rozhkov, N. V., Aravin, A. A., Zelentsova, E. S., Schostak, N. G., Sachidanandam, R., McCombie, W. R., Hannon, G. J. , Evgen'ev, M. B. (2010) Small RNA-based silencing strategies for transposons in the process of invading Drosophila species. RNA, 16(8) pp. 1634-1645.

Cifuentes, D., Xue, H. L., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E. B., Mane, S., Hannon, G. J., Lawson, N. D., Wolfe, S. A. , Giraldez, A. J. (2010) A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity. Science, 328(5986) pp. 1694-1698.

Karginov, F. V., Cheloufi, S., Chong, M. M. W., Stark, A., Smith, A. D. , Hannon, G. J. (2010) Diverse Endonucleolytic Cleavage Sites in the Mammalian Transcriptome Depend upon MicroRNAs, Drosha, and Additional Nucleases. Molecular Cell, 38(6) pp. 781-788.

Cheloufi, S., Dos Santos, C. O., Chong, M. M. W. , Hannon, G. J. (2010) A Dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature, 465(7298) pp. 584-U76.

Burbano, H. A., Hodges, E., Green, R. E., Briggs, A. W., Krause, J., Meyer, M., Good, J. M., Maricic, T., Johnson, P. L. F., Xuan, Z. Y., Rooks, M., Bhattacharjee, A., Brizuela, L., Albert, F. W., De La Rasilla, M., Fortea, J., Rosas, A., Lachmann, M., Hannon, G. J. , Paabo, S. (2010) Targeted investigation of the neandertal genome by array-based sequence capture. Science, 328(5979) pp. 723-725.

Malone, C. D. , Hannon, G. J. (2010) Molecular Evolution of piRNA and Transposon Control Pathways in Drosophila. Cold Spring Harb Symp Quant Biol, pp. 225-234.

Rozhkov, N. V., Aravin, A. A., Sachidanandam, R., Hannon, G. J., Sokolova, O. N., Zelentsova, E. S., Shostak, N. G. , Evgen'ev, M. B. (2010) The RNA interference system differently responds to the same mobile element in distant Drosophila species. Doklady Biochemistry and Biophysics, 431(1) pp. 79-81.

Choi, Y., Nagy, A., Tam, O. H., Hannon, G. J. , Millar, S. E. (2010) The miRNA-processing enzyme Drosha is required for hair follicle regression, hair shaft differentiation, long-term maintenance of hair follicle stem cells, and epidermal homeostasis. Journal of Investigative Dermatology, 130(S1) pp. S108.

Teta, M., Choi, Y., Andl, T., Murchison, E. P., Nagy, A., Hannon, G. J. , Millar, S. E. (2010) Dicer is required in adult skin for maintenance of rapidly proliferating hair follicle matrix cells, hair shaft formation, and catagen. Journal of Investigative Dermatology, 130(S1) pp. S106.

Christodoulou, F., Raible, F., Tomer, R., Simakov, O., Trachana, K., Klaus, S., Snyman, H., Hannon, G. J., Bork, P. , Arendt, D. (2010) Ancient animal microRNAs and the evolution of tissue identity. Nature, 463(7284) pp. 1084-1088.

Erlich, Y., Gordon, A., Brand, M., Hannon, G. J. , Mitra, P. P. (2010) Compressed genotyping. IEEE Transactions on Information Theory, 56(2) pp. 706-723.

Edvardson, S., Shaag, A., Zenvirt, S., Erlich, Y., Hannon, G. J., Shanske, A. L., Gomori, J. M., Ekstein, J. , Elpeleg, O. (2010) Joubert Syndrome 2 (JBTS2) in Ashkenazi Jews Is Associated with a TMEM216 Mutation. American Journal of Human Genetics, 86(1) pp. 93-97.

Karginov, F. V. , Hannon, G. J. (2010) The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea. Molecular Cell, 37(1) pp. 7-19.

Murchison, E. P., Tovar, C., Hsu, A., Bender, H. S., Kheradpour, P., Rebbeck, C. A., Obendorf, D., Conlan, C., Bahlo, M., Blizzard, C. A., Pyecroft, S., Kreiss, A., Kellis, M., Stark, A., Harkins, T. T., Marshall Graves, J. A., Woods, G. M., Hannon, G. J. , Papenfuss, A. T. (2010) The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer. Science, 327(5961) pp. 84-7.

Berezikov, E., Liu, N., Flynt, A. S., Hodges, E., Rooks, M., Hannon, G. J. , Lai, E. C. (2010) Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nature Genetics, 42(1) pp. 6-9.

Igartua, C., Turner, E. H., Ng, S. B., Hodges, E., Hannon, G. J., Bhattacharjee, A., Rieder, M. J., Nickerson, D. A. , Shendure, J. (2010) Targeted enrichment of specific regions in the human genome by array hybridization. Current Protocols in Human Genetics, (SUPPL.) pp. 18.3.1-18.3.14.

Rosa-Rosa, J. M., Gracia-Aznarez, F. J., Hodges, E., Pita, G., Rooks, M., Xuan, Z., Bhattacharjee, A., Brizuela, L., Silva, J. M., Hannon, G. J. , Benitez, J. (2010) Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting. PLoS One, 5(4) pp. e9976.

Olive, V., Bennett, M. J., Walker, J. C., Ma, C., Jiang, I., Cordon-Cardo, C., Li, Q. J., Lowe, S. W., Hannon, G. J. , He, L. (2009) miR-19 is a key oncogenic component of mir-17-92. Genes & Development, 23(24) pp. 2839-2849.

Aravin, A. A., van der Heijden, G. W., Castaneda, J., Vagin, V. V., Hannon, G. J. , Bortvin, A. (2009) Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice. Plos Genetics, 5(12) pp. e1000764.

Smith, A. D., Chung, W. Y., Hodges, E., Kendall, Jude T., Hannon, G. J., Hicks, J. B., Xuan, Z. , Zhang, M. Q. (2009) Updates to the RMAP short-read mapping software. Bioinformatics, 25(21) pp. 2841-2842.

Bric, A., Miething, C., Bialucha, C. U., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M. H., Hicks, J. B., McCombie, W. R., Hemann, M. T., Hannon, G. J., Powers, S. , Lowe, S. W. (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell, 16(4) pp. 324-35.

Erlich, Yaniv, Gordon, Assaf, Brand, Michael, Hannon, Gregory J , Mitra, Partha P (2009) Compressed Genotyping. IEEE Transactions on Information Theory,

Hodges, E., Smith, A. D., Kendall, J. T., Xuan, Z., Ravi, K., Rooks, M., Zhang, M. Q., Ye, K., Bhattacharjee, A., Brizuela, L., McCombie, W. R., Wigler, M. H., Hannon, G. J. , Hicks, J. B. (2009) High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Research, 19(9) pp. 1593-1605.

Hodges, E., Rooks, M., Xuan, Z., Bhattacharjee, A., Gordon, D. B., Brizuela, L., McCombie, W. R. , Hannon, G. J. (2009) Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing. Nature Protocols, 4(6) pp. 960-974.

Malone, C. D., Brennecke, J., Dus, M., Stark, A., McCombie, W. R., Sachidanandam, R. , Hannon, G. J. (2009) Specialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary. Cell, 137(3) pp. 522-535 .

Ezhkova, E., Pasolli, H. A., Parker, J. S., Stokes, N., Su, I. H., Hannon, G. J., Tarakhovsky, A. , Fuchs, E. (2009) Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells. Cell, 136(6) pp. 1122-1135.

Premsrirut, P. K., Miething, C., Zuber, J., Yong, K. S., Hannon, G. J. , Lowe, S. W. (2009) Conditional Regulation of Tumor Suppressor Genes in Vivo Using Rna Interference. Journal of Investigative Medicine, 57(3)

Uziel, T., Karginov, F. V., Xie, S. Q., Parker, J. S., Wang, Y. D., Gajjar, A., He, L., Ellison, D., Gilbertson, R. J., Hannon, G. J. , Roussel, M. F. (2009) The miR-17 similar to 92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proceedings of the National Academy of Sciences of the United States of America, 106(8) pp. 2812-2817.

Malone, C. D. , Hannon, G. J. (2009) Small RNAs as Guardians of the Genome. Cell, 136(4) pp. 656-668.

Fejes-Toth, K., Sotirova, V., Sachidanandam, R., Assaf, G., Hannon, G. J., Kapranov, P., Foissac, S., Willingham, A. T., Duttagupta, R., Dumais, E. , Gingeras, T. R. (2009) Post-transcriptional processing generates a diversity of 5'-modified long and short RNAs. Nature, 457(7232) pp. 1028-1032.

Castellano, L., Giamas, G., Jacob, J., Coombes, R. C., Lucchesi, W., Thiruchelvam, P., Barton, G., Jiao, L. R., Wait, R., Waxman, J., Hannon, G. J. , Stebbing, J. (2009) The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response. Proceedings of the National Academy of Sciences of the United States of America, 106(37) pp. 15732-15737.

Couvillion, M. T., Lee, S. R., Hogstad, B., Malone, C. D., Tonkin, L. A., Sachidanandam, R., Hannon, G. J. , Collins, K. (2009) Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes and Development, 23(17) pp. 2016-2032.

Czech, B., Zhou, R., Erlich, Y., Brennecke, J., Binari, R., Villalta, C., Gordon, A., Perrimon, N. , Hannon, G. J. (2009) Hierarchical Rules for Argonaute Loading in Drosophila. Molecular Cell, 36(3) pp. 445-456.

Erlich, Y., Chang, K., Gordon, A., Ronen, R., Navon, O., Rooks, M. , Hannon, G. J. (2009) DNA Sudoku - Harnessing high-throughput sequencing for multiplexed specimen analysis. Genome Research, 19(7) pp. 1243-1253.

Fabian, M. R., Mathonnet, G., Sundermeier, T., Mathys, H., Zipprich, J. T., Svitkin, Y. V., Rivas, F., Jinek, M., Wohlschlegel, J., Doudna, J. A., Chen, C. Y. A., Shyu, A. B., Yates Iii, J. R., Hannon, G. J., Filipowicz, W., Duchaine, T. F. , Sonenberg, N. (2009) Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation. Molecular Cell, 35(6) pp. 868-880.

Peoples, M., Sadeghieh, S., Hwang, E., Chen, S., Hannon, G. J., Long, C. , Westhusin, M. (2009) Inhibition of Foot and Mouth Disease Virus in Vitro Using Rna Interference. Reproduction Fertility and Development, 21(1) pp. 103.

Rechavi, O., Erlich, Y., Amram, H., Flomenblit, L., Karginov, F. V., Goldstein, I., Hannon, G. J. , Kloog, Y. (2009) Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs. Genes and Development, 23(16) pp. 1971-1979.

Silva, J. M., Ezhkova, E., Silva, J., Heart, S., Castillo, M., Campos, Y., Castro, V., Bonilla, F., Cordon-Cardo, C., Muthuswamy, S. K., Powers, S., Fuchs, E. , Hannon, G. J. (2009) Cyfip1 Is a Putative Invasion Suppressor in Epithelial Cancers. Cell, 137(6) pp. 1047-1061.

Tessanne, K., Stroud, T., Long, C., Hannon, G. J., Sadeghieh, S., Hwang, E., Chen, S., Polejaeva, I. , Westhusin, M. (2009) Development of Transgenic Livestock with Reduced Myostatin Expression Using Rna Interference. Reproduction Fertility and Development, 21(1) pp. 251.

Vagin, V. V., Hannon, G. J. , Aravin, A. A. (2009) Arginine methylation as a molecular signature of the Piwi small RNA pathway. Cell Cycle, 8(24) pp. 4003-4004.

Vagin, V. V., Wohlschlegel, J., Qu, J., Jonsson, Z., Huang, X., Chuma, S., Girard, A., Sachidanandam, R., Hannon, G. J. , Aravin, A. A. (2009) Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes and Development, 23(15) pp. 1749-1762.

Xu, Q., Schlabach, M. R., Hannon, G. J. , Elledge, S. J. (2009) Design of 240,000 orthogonal 25mer DNA barcode probes. Proceedings of the National Academy of Sciences of the United States of America, 106(7) pp. 2289-2294.

Zhou, R., Czech, B., Brennecke, J., Sachidanandam, R., Wohlschlegel, J. A., Perrimon, N. , Hannon, G. J. (2009) Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA, 15(10) pp. 1886-1895.

Brennecke, J., Malone, C. D., Aravin, A. A., Sachidanandam, R., Stark, A. , Hannon, G. J. (2008) An epigenetic role for maternally inherited piRNAs in transposon silencing. Science, 322(5906) pp. 1387-92.

Zender, L., Xue, W., Zuber, J., Semighini, C. P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J. M., Schirmacher, P., McCombie, W. R., Wigler, M. H., Hicks, J. B., Hannon, G. J., Powers, S. , Lowe, S. W. (2008) An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell, 135(5) pp. 852-864.

Erlich, Y., Mitra, P. P., Delabastide, M., McCombie, W. R. , Hannon, G. J. (2008) Alta-Cyclic: a self-optimizing base caller for next-generation sequencing. Nature Methods, 5(8) pp. 679 - 682.

Teta, M., Thomas, A., Okegbe, T., Murchison, E. P., Nagy, A., Hannon, G. J. , Millar, S. E. (2008) Dicer is required for maintenance of hair follicle stem cells in adult skin. Developmental Biology, 319(2) pp. 556-556.

Burgess, D. J., Doles, J., Zender, L., Xue, W., Ma, B., McCombie, W. R., Hannon, G. J., Lowe, S. W. , Hemann, M. T. (2008) Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A, 105(25) pp. 9053-9058.

Murchison, E. P., Kheradpour, P., Sachidanandam, R., Smith, C., Hodges, E., Xuan, Z., Kellis, M., Grutzner, F., Stark, A. , Hannon, G. J. (2008) Conservation of small RNA pathways in platypus. Genome Research, 18(6) pp. 995-1004.

Tworkowski, K. A., Chakraborty, A. A., Samuelson, A. V., Seger, Y. R., Narita, M., Hannon, G. J., Lowe, S. W. , Tansey, W. P. (2008) Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Proc Natl Acad Sci U S A, 105(16) pp. 6103-6108.

Mi, S. J., Cai, T., Hu, Y. G., Chen, Y., Hodges, E., Ni, F. R., Wu, L., Li, S., Zhou, H., Long, C. Z., Chen, S., Hannon, G. J. , Qi, Y. J. (2008) Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell, 133(1) pp. 116-127.

Teta, M., Andl, T., Okegbe, T., Murchison, E. P., Nagy, A., Hannon, G. J. , Millar, S. E. (2008) Global changes in mRNA levels and failure of hair follicle stem cell maintenance in adult Dicer-deleted skin. Journal of Investigative Dermatology, 128(Suppl.) pp. S154-S154.

Benetti, R., Gonzalo, S., Jaco, I., Munoz, P., Gonzalez, S., Schoeftner, S., Murchison, E. P., Andl, T., Chen, T. P., Klatt, P., Li, E., Serrano, M., Millar, S., Hannon, G. J. , Blasco, M. A. (2008) A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nature Structural & Molecular Biology, 15(3) pp. 268-279.

Silva, J. M., Marran, K., Parker, J. S., Silva, J., Golding, M., Schlabach, M. R., Elledge, S. J., Hannon, G. J. , Chang, K. (2008) Profiling essential genes in human mammary cells by multiplex RNAi screening. Science, 319(5863) pp. 617-20.

Chen, J. F., Murchison, E. P., Tang, R., Callis, T. E., Tatsuguchi, M., Deng, Z., Rojas, M., Hammond, S. M., Schneider, M. D., Selzman, C. H., Meissner, G., Patterson, C., Hannon, G. J. , Wang, D. Z. (2008) Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A, 105(6) pp. 2111-2116.

Schlabach, M. R., Luo, J., Solimini, N. L., Hu, G., Xu, Q. K., Li, M. Z., Zhao, Z. M., Smogorzewska, A., Sowa, M. E., Ang, X. L. L., Westbrook, T. F., Liang, A. C., Chang, K., Hackett, J. A., Harper, J. W., Hannon, G. J. , Elledge, S. J. (2008) Cancer proliferation gene discovery through functional Genomics. Science, 319(5863) pp. 620-624.

Aravin, A. A. , Hannon, G. J. (2008) Small RNA silencing pathways in germ and stem cells. Cold Spring Harb Symp Quant Biol, 73 pp. 283-90.

Aravin, A. A., Sachidanandam, R., Bourc'his, D., Schaefer, C., Pezic, D., Toth, K. F., Bestor, T. , Hannon, G. J. (2008) A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice. Molecular Cell, 31(6) pp. 785-799.

Czech, B., Malone, C. D., Zhou, R., Stark, A., Schlingeheyde, C., Dus, M., Perrimon, N., Kellis, M., Wohlschlegel, J. A., Sachidanandam, R., Hannon, G. J. , Brennecke, J. (2008) An endogenous small interfering RNA pathway in Drosophila. Nature, 453(7196) pp. 798-802.

De Pietri Tonelli, D., Pulvers, J. N., Haffner, C., Murchison, E. P., Hannon, G. J. , Huttner, W. B. (2008) miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development, 135(23) pp. 3911-3921.

Du, J., Jablonski, S., Yen, T. J. , Hannon, G. J. (2008) Astrin regulates Aurora-A localization. Biochem Biophys Res Commun, 370(2) pp. 213-9.

Girard, A. , Hannon, G. J. (2008) Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol, 18(3) pp. 136-148.

Haiser, H. J., Karginov, F. V., Hannon, G. J. , Elliot, M. A. (2008) Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor. Nucleic Acids Research, 36(3) pp. 732-741.

Olson, A. J., Brennecke, J., Aravin, A. A., Hannon, G. J. , Sachidanandam, R. (2008) Analysis of large-scale sequencing of small RNAs. Pacific Symposium on Biocomputing, pp. 126-136.

Tam, O. H., Aravin, A. A., Stein, P., Girard, A., Murchison, E. P., Cheloufi, S., Hodges, E., Anger, M., Sachidanandam, R., Schultz, R. M. , Hannon, G. J. (2008) Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature, 453(7194) pp. 534-538.

Tyler, D. M., Okamura, K., Chung, W. J., Hagen, J. W., Berezikov, E., Hannon, G. J. , Lai, E. C. (2008) Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes and Development, 22(1) pp. 26-36.

Warren, W. C., Hillier, L. W., Marshall Graves, J. A., Birney, E., Ponting, C. P., Grützner, F., Belov, K., Miller, W., Clarke, L., Chinwalla, A. T., Yang, S. P., Heger, A., Locke, D. P., Miethke, P., Waters, P. D., Veyrunes, F., Fulton, L., Fulton, B., Graves, T., Wallis, J., Puente, X. S., López-Otín, C., Ordóñez, G. R., Eichler, E. E., Chen, L., Cheng, Z., Deakin, J. E., Alsop, A., Thompson, K., Kirby, P., Papenfuss, A. T., Wakefield, M. J., Olender, T., Lancet, D., Huttley, G. A., Smit, A. F. A., Pask, A., Temple-Smith, P., Batzer, M. A., Walker, J. A., Konkel, M. K., Harris, R. S., Whittington, C. M., Wong, E. S. W., Gemmell, N. J., Buschiazzo, E., Vargas Jentzsch, I. M., Merkel, A., Schmitz, J., Zemann, A., Churakov, G., Ole Kriegs, J., Brosius, J., Murchison, E. P., Sachidanandam, R., Smith, C., Hannon, G. J., Tsend-Ayush, E., McMillan, D., Attenborough, R., Rens, W., Ferguson-Smith, M., Lefèvre, C. M., Sharp, J. A., Nicholas, K. R., Ray, D. A., Kube, M., Reinhardt, R., Pringle, T. H., Taylor, J., Jones, R. C., Nixon, B., Dacheux, J. L., Niwa, H., Sekita, Y., Huang, X., Stark, A., Kheradpour, P., Kellis, M., Flicek, P., Chen, Y., Webber, C., Hardison, R., Nelson, J., Hallsworth-Pepin, K., Delehaunty, K., Markovic, C., Minx, P., Feng, Y., Kremitzki, C., Mitreva, M., Glasscock, J., Wylie, T., Wohldmann, P., Thiru, P., Nhan, M. N., Pohl, C. S., Smith, S. M., Hou, S. , Renfree, M. B. (2008) Genome analysis of the platypus reveals unique signatures of evolution. Nature, 453(7192) pp. 175-183.

Zhou, R., Hotta, I., Denli, A. M., Hong, P., Perrimon, N. , Hannon, G. J. (2008) Comparative Analysis of Argonaute-Dependent Small RNA Pathways in Drosophila. Molecular Cell, 32(4) pp. 592-599.

Ibarra, I., Erlich, Y., Muthuswamy, S. K., Sachidanandam, R. , Hannon, Gregory J. (2007) A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev, 21(24) pp. 3238-43.

Karginov, F. V., Conaco, C., Xuan, Z. Y., Schmidt, B. H., Parker, J. S., Mandel, G. , Hannon, G. J. (2007) A biochemical approach to identifying microRNA targets. Proceedings of the National Academy of Sciences of the United States of America, 104(49) pp. 19291-6.

Stark, A., Kheradpour, P., Parts, L., Brennecke, J., Hodges, E., Hannon, G. J. , Kellis, M. (2007) Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res, 17(12) pp. 1865-1879.

Hodges, E., Xuan, Z. Y., Balija, V., Kramer, M. R., Molla, M. N., Smith, S. W., Middle, C. M., Rodesch, M. J., Albert, T. J., Hannon, G. J. , McCombie, W. R. (2007) Genome-wide in situ exon capture for selective resequencing. Nature Genetics, 39(12) pp. 1522-7.

Aravin, A. A., Hannon, G. J. , Brennecke, J. (2007) The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race. Science, 318(5851) pp. 761-764.

He, L., He, X., Lowe, S. W. , Hannon, G. J. (2007) microRNAs join the p53 network - another piece in the tumour-suppression puzzle. Nat Rev Cancer, 7(11) pp. 819-822.

Stark, A., Lin, M. F., Kheradpour, P., Pedersen, J. S., Parts, L., Carlson, J. W., Crosby, M. A., Rasmussen, M. D., Roy, S., Deoras, A. N., Ruby, J. G., Brennecke, J., Hodges, E., Hinrichs, A. S., Caspi, A., Park, S. W., Han, M. V., Maeder, M. L., Polansky, B. J., Robson, B. E., Aerts, S., van Helden, J., Hassan, B., Gilbert, D. G., Eastman, D. A., Rice, M., Weir, M., Hahn, M. W., Park, Y., Dewey, C. N., Pachter, L., Kent, W. J., Haussler, D., Lai, E. C., Bartel, D. P., Hannon, G. J., Kaufman, T. C., Eisen, M. B., Clark, A. G., Smith, D., Celniker, S. E., Gelbart, W. M. , Kellis, M. (2007) Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature, 450(7167) pp. 219-232.

Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., Hannon, G. J. , Abeliovich, A. (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science, 317(5842) pp. 1220-4.

Dickins, R. A., McJunkin, K., Hernando, E., Premsrirut, P. K., Krizhanovsky, V., Burgess, D. J., Kim, S. Y., Cordon-Cardo, C., Zender, L., Hannon, G. J. , Lowe, S. W. (2007) Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet, 39(7) pp. 914 - 921.

He, L., He, X., Lim, L. P., De Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., Jackson, A. L., Linsley, P. S., Chen, C., Lowe, S. W., Cleary, M. A. , Hannon, G. J. (2007) A microRNA component of the p53 tumour suppressor network. Nature, 447(7148) pp. 1130-4.

Aravin, A. A., Sachidanandam, R., Girard, A., Fejes-Toth, K. , Hannon, G. J. (2007) Developmentally regulated piRNA clusters implicate MILI in transposon control. Science, 316(5825) pp. 744-7.

Draviam, V. M., Stegmeier, F., Nalepa, G., Sowa, M. E., Chen, J., Liang, A., Hannon, G. J., Sorger, P. K., Harper, J. W. , Elledge, S. J. (2007) A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nature Cell Biology, 9(5) pp. 556-564.

Zhao, T., Li, G. L., Mi, S. J., Li, S., Hannon, G. J., Wang, X. J. , Qi, Y. J. (2007) A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev, 21(10) pp. 1190-1203.

Carmell, M. A., Girard, A., van de Kant, H. J. G., Bourc'his, D., Bestor, T. H., de Rooij, D. G. , Hannon, G. J. (2007) MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline. Developmental Cell, 12(4) pp. 503-514.

Houwing, S., Kamminga, L. M., Berezikov, E., Cronembold, D., Girard, A., van den Elst, H., Filippov, D. V., Blaser, H., Raz, E., Moens, C. B., Plasterk, R. H. A., Hannon, G. J., Draper, B. W. , Ketting, R. F. (2007) A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in zebrafish. Cell, 129(1) pp. 69-82.

Stegmeier, F., Rape, M., Draviam, V. M., Nalepa, G., Sowa, M. E., Ang, X. L. L., McDonald, E. R., Li, M. Z., Hannon, G. J., Sorger, P. K., Kirschner, M. W., Harper, J. W. , Elledge, S. J. (2007) Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature, 446(7138) pp. 876-881.

Brennecke, J., Aravin, A. A., Stark, A., Dus, M., Kellis, M., Sachidanandam, R. , Hannon, G. J. (2007) Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell, 128(6) pp. 1089-103.

Murchison, E. P., Stein, P., Xuan, Z. Y., Pan, H., Zhang, M. Q., Schultz, R. M. , Hannon, G. J. (2007) Critical roles for Dicer in the female germline. Genes Dev, 21(6) pp. 682-93.

Girard, A. , Hannon, G. J. (2007) [The role of piRNAs in mouse spermatogenesis.]. J Soc Biol, 201(4) pp. 411-8.

Stegh, A. H., Kim, H., Bachoo, R. M., Forloney, K. L., Zhang, J., Schulze, H., Park, K., Hannon, G. J., Yuan, J. Y., Louis, D. N., DePinho, R. A. , Chin, L. (2007) Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev, 21(1) pp. 98-111.

He, X., He, L. , Hannon, G. J. (2007) The guardian's little helper: MicroRNAs in the p53 tumor suppressor network. Cancer Research, 67(23) pp. 11099-11101.

Qi, Y., He, X., Wang, X. J., Kohany, O., Jurka, J. , Hannon, G. J. (2006) Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature, 443(7114) pp. 1008-12.

Chang, K., Elledge, S. J. , Hannon, G. J. (2006) Lessons from Nature: microRNA-based shRNA libraries. Nat Methods, 3(9) pp. 707-14.

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S. T., Luk, J. M., Wigler, M. H., Hannon, G. J., Mu, D., Lucito, R., Powers, S. , Lowe, S. W. (2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell, 125(7) pp. 1253-67.

Andl, T., Murchison, E. P., Liu, Fei, Zhang, Yi, Yunta-Gonzalez, M., Tobias, J. W., Andl, C. D., Seykora, J. T., Hannon, G. J. , Millar, S. E. (2006) The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles. Current Biology, 16(10) pp. 1041-1049.

Golding, M. C., Long, C. R., Carmell, M. A., Hannon, G. J. , Westhusin, M. E. (2006) Suppression of prion protein in livestock by RNA interference. Proc Natl Acad Sci U S A, 103(14) pp. 5285-90.

Mason, D. X., Keppler, D., Zhang, J., Jackson, T. J., Seger, Y. R., Matsui, S., Abreo, F., Cowell, J. K., Hannon, G. J., Lowe, S. W. , Lin, A. W. (2006) Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts. Carcinogenesis, 27(2) pp. 350-359.

Olson, A., Sheth, N., Lee, J. S., Hannon, G. J. , Sachidanandam, R. (2006) RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs. Nucleic Acids Res, 34(Databa) pp. D153-7.

Dickins, R. A., Premsrirut, P., McJunkin, K., Kim, S. Y., Hannon, G. J. , Lowe, S. W. (2006) Tetracycline-regulated p53 knockdown in cells and transgenic mice. Toxicologic Pathology, 34(7) pp. 1006-1006.

Girard, A., Sachidanandam, R., Hannon, G. J. , Carmell, M. A. (2006) A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature, 442(7099) pp. 199-202.

Hannon, G. J., Rivas, F. V., Murchison, E. P. , Steitz, J. A. (2006) The Expanding Universe of Noncoding RNAs. Cold Spring Harb Symp Quant Biol, 71 pp. 551-564.

Valencia-Sanchez, M. A., Liu, J., Hannon, G. J. , Parker, R. (2006) Control of translation and mRNA degradation by miRNAs and siRNAs. Genes and Development, 20(5) pp. 515-524.

Liu, J. D., Rivas, F. V., Wohlschlegel, J., Yates, J. R., Parker, R. , Hannon, G. J. (2005) A role for the P-body component GW182 in microRNA function. Nature Cell Biology, 7(12) pp. 1261-1266.

Dickins, R. A., Hemann, M. T., Zilfou, J. T., Simpson, D. R., Ibarra, I., Hannon, G. J. , Lowe, S. W. (2005) Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet, 37(11) pp. 1289-95.

Silva, J. M., Li, M. Z., Chang, K., Ge, W., Golding, M. C., Rickles, R. J., Siolas, D., Hu, G., Paddison, P. J., Schlabach, M. R., Sheth, N., Bradshaw, J., Burchard, J., Kulkarni, A., Cavet, G., Sachidanandam, R., McCombie, W. R., Cleary, M. A., Elledge, S. J. , Hannon, G. J. (2005) Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet, 37(11) pp. 1281-8.

Qi, Yijun , Hannon, Gregory J. (2005) Uncovering RNAi mechanisms in plants: biochemistry enters the foray. FEBS Lett, 579(26) pp. 5899-903.

Elledge, S. J. , Hannon, G. J. (2005) An open letter to cancer researchers. Science, 310(5747) pp. 439-+.

Zender, L., Spector, M. S., Xue, W., Flemming, P., Mu, D., Cordon-Cardo, C., Powers, S., Hannon, G. J., Lucito, R. , Lowe, S. W. (2005) Representational oligonucleotide microarray (ROMA) identifies cIAP1/cIAP2 as candidate oncogenes in mouse and human hepatocarcinogenesis-validation of cIAP1 as a therapeutic target in liver cancer in a new mouse model of hepatocellular carcinoma. Hepatology, 42(4) pp. 244A-244A.

Stegmeier, F., Hu, G., Rickles, R. J., Hannon, G. J. , Elledge, S. J. (2005) A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America, 102(37) pp. 13212-13217.

Murchison, E. P., Partridge, J. F., Tam, O. H., Cheloufi, S. , Hannon, G. J. (2005) Characterization of Dicer-deficient murine embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 102(34) pp. 12135-40.

Qi, Yijun, Denli, Ahmet M. , Hannon, Gregory J. (2005) Biochemical specialization within Arabidopsis RNA silencing pathways. Mol Cell, 19(3) pp. 421-8.

Liu, J., Valencia-Sanchez, M. A., Hannon, G. J. , Parker, R. (2005) MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nature Cell Biology, 7(7) pp. 719-23.

He, L., Thomson, J. M., Hemann, M. T., Hernando-Monge, E., Mu, D., Goodson, S., Powers, S., Cordon-Cardo, C., Lowe, S. W., Hannon, G. J. , Hammond, S. M. (2005) A microRNA polycistron as a potential human oncogene. Nature, 435(7043) pp. 828-33.

Schramke, V., Sheedy, D. M., Denli, A. M., Bonila, C., Ekwall, K., Hannon, G. J. , Allshire, R. C. (2005) RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription. Nature, 435(7046) pp. 1275-1279.

Westbrook, T. F., Martin, E. S., Schlabach, M. R., Leng, Y. M., Liang, A. C., Feng, B., Zhao, J. J., Roberts, T. M., Mandel, G., Hannon, G. J., DePinho, R. A., Chin, L. , Elledge, S. J. (2005) A genetic screen for candidate tumor suppressors identifies REST. Cell, 121(6) pp. 837-848.

Rivas, Fabiola V., Tolia, Nirja H., Song, Ji-Joon, Aragon, Juan P., Liu, Jidong, Hannon, Gregory J. , Joshua-Tor, Leemor (2005) Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol, 12(4) pp. 340-9.

Elgin, S. C. R., Haynes, K., Brower-Toland, B., Gracheva, E., Hannon, G. J. , Caudy, A. A. (2005) RNAi-dependent assembly of heterochromatin in Drosophila. Faseb Journal, 19(5) pp. A1720-A1720.

Olson, A., Sheth, N., Lee, J., Hannon, G. J. , Sachidanandam, R. (2005) Rnai codex - a comprehensive RNAi resource. Briefings in Bioinformatics, 6(1) pp. 104-106.

Siolas, D., Lerner, C., Burchard, J., Ge, W., Linsley, P. S., Paddison, P. J., Hannon, G. J. , Cleary, M. A. (2005) Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol, 23(2) pp. 227-31.

Schramke, V., Sheedy, D. M., Denli, A. M., Bonila, C., Ekwall, K., Hannon, G. J. , Allshire, R. C. (2005) Erratum (Retracted article): RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription (Nature (2005) 435 (1275-1279)). Nature, 437(7061) pp. 1057.

Zender, L., Xue, W., Cordon-Cardo, C., Hannon, G. J., Lucito, R., Powers, S., Flemming, P., Spector, M. S. , Lowe, S. W. (2005) Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors. Cold Spring Harb Symp Quant Biol, 70(1) pp. 251-261.

Cleary, M. A., Kilian, K., Wang, Y., Bradshaw, J., Cavet, G., Ge, W., Kulkarni, A., Paddison, P. J., Chang, K., Sheth, N., Leproust, E., Coffey, E. M., Burchard, J., McCombie, W. R., Linsley, P. , Hannon, G. J. (2004) Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat Methods, 1(3) pp. 241-8.

Dike, S., Balija, V. S., Nascimento, L. U., Xuan, Z. Y., Ou, J., Zutavern, T., Palmer, L. E., Hannon, G. J., Zhang, M. Q. , McCombie, W. R. (2004) The mouse genome: experimental examination of gene predictions and transcriptional start sites. Genome Res, 14(12) pp. 2424-9.

Denli, A. M., Tops, B. B., Plasterk, R. H., Ketting, R. F. , Hannon, G. J. (2004) Processing of primary microRNAs by the Microprocessor complex. Nature, 432(7014) pp. 231-5.

Silva, J., Chang, K., Hannon, G. J. , Rivas, F. V. (2004) RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age. Oncogene, 23(51) pp. 8401-9.

Paddison, P. J., Cleary, M., Silva, J. M., Chang, K., Sheth, N., Sachidanandam, R. , Hannon, G. J. (2004) Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods, 1(2) pp. 163-7.

Hannon, G. J. , Rossi, J. J. (2004) Unlocking the potential of the human genome with RNA interference. Nature, 431(7006) pp. 371-8.

Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J. J., Hammond, S. M., Joshua-Tor, L. , Hannon, G. J. (2004) Argonaute2 is the catalytic engine of mammalian RNAi. Science, 305(5689) pp. 1437-41.

Song, J. J., Smith, S. K., Hannon, G. J. , Joshua-Tor, L. (2004) Crystal structure of argonaute and its implications for RISC slicer activity. Science, 305(5689) pp. 1434-1437.

He, L. , Hannon, G. J. (2004) MicroRNAs: Small RNAs with a big role in gene regulation. Nature Reviews Genetics, 5(8) pp. 522-532.

Hemann, M. T., Zilfou, J. T., Zhao, Z., Burgess, D. J., Hannon, G. J. , Lowe, S. W. (2004) Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A, 101(25) pp. 9333-8.

Du, J. , Hannon, G. J. (2004) Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion. Proc Natl Acad Sci U S A, 101(24) pp. 8975-80.

Murchison, E. P. , Hannon, G. J. (2004) miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol, 16(3) pp. 223-9.

Svoboda, P., Stein, P., Anger, M., Bernstein, E., Hannon, G. J. , Schultz, R. M. (2004) RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos. Developmental Biology, 269(1) pp. 276-285.

Silva, J. M., Mizuno, H., Brady, A., Lucito, R. , Hannon, G. J. (2004) RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells. Proc Natl Acad Sci U S A, 101(17) pp. 6548-52.

Paddison, P. J., Silva, J. M., Conklin, D. S., Schlabach, M., Li, M., Aruleba, S., Balija, V., O'Shaughnessy, A., Gnoj, L., Scobie, K., Chang, K., Westbrook, T., Cleary, M., Sachidanandam, R., McCombie, W. R., Elledge, S. J. , Hannon, G. J. (2004) A resource for large-scale RNA-interference-based screens in mammals. Nature, 428(6981) pp. 427-31.

Carmell, M. A. , Hannon, G. J. (2004) RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol, 11(3) pp. 214-8.

Gupta, S., Schoer, R. A., Egan, J. E., Hannon, G. J. , Mittal, V. (2004) Inducible, reversible, and stable RNA interference in mammalian cells. Proc Natl Acad Sci U S A, 101(7) pp. 1927-32.

Caudy, A. A. , Hannon, G. J. (2004) Induction and biochemical purification of RNA-induced silencing complex from Drosophila S2 cells. Methods Mol Biol, 265 pp. 59-72.

Hannon, G. J. , Conklin, D. S. (2004) RNA interference by short hairpin RNAs expressed in vertebrate cells. In: Methods Mol Biol. Methods Mol Biol, 257 pp. 255-66.

Kan, J. L. C., Griffin, G. , Hannon, G. J. (2004) Mining the genome with RNAi to select cancer drug targets. Drug Discovery Today: Therapeutic Strategies, 1(4) pp. 397-401.

Song, J. J., Liu, J., Tolia, N. H., Schneiderman, J., Smith, S. K., Martienssen, R. A., Hannon, G. J. , Joshua-Tor, L. (2003) The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol, 10(12) pp. 1026-32.

Narita, M., Nunez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J. , Lowe, S. W. (2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell, 113(6) pp. 703-716.

Hemann, M. T., Fridman, J. S., Zilfou, J. T., Hernando, E., Paddison, P. J., Cordon-Cardo, C., Hannon, G. J. , Lowe, S. W. (2003) An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nature Genetics, 33(3) pp. 396-400.

Bernstein, E., Kim, S. Y., Carmell, M. A., Murchison, E. P., Alcorn, H., Li, M. Z., Mills, A. A., Elledge, S. J., Anderson, K. V. , Hannon, G. J. (2003) Dicer is essential for mouse development. Nature Genetics, 35(3) pp. 215-217.

Carmell, M. A., Zhang, L., Conklin, D. S., Hannon, G. J. , Rosenquist, T. A. (2003) Germline transmission of RNAi in mice. Nature Structural Biology, 10(2) pp. 91-92.

Caudy, A. A., Ketting, R. F., Hammond, S. M., Denli, A. M., Bathoorn, A. M. P., Tops, B. B. J., Silva, J. M., Myers, M. M., Hannon, G. J. , Plasterk, R. H. A. (2003) A micrococcal nuclease homologue in RNAi effector complexes. Nature, 425(6956) pp. 411-414.

Denli, A. M. , Hannon, G. J. (2003) RNAi: An ever-growing puzzle. Trends in Biochemical Sciences, 28(4) pp. 196-201.

Paddison, P. J. , Hannon, G. J. (2003) siRNAs and shRNAs: Skeleton keys to the human genome. Current Opinion in Molecular Therapeutics, 5(3) pp. 217-224.

Palmer, L. E., O'Shaughnessy, A. L., Preston, R. R., Santos, L., Balija, V. S., Nascimento, L. U., Zutavern, T. L., Henthorn, P. S., Hannon, G. J. , McCombie, W. R. (2003) A Survey of Canine Expressed Sequence Tags and a Display of Their Annotations Through a Flexible Web-Based Interface. Journal of Heredity, 94(1) pp. 15-22.

Silva, J. M., Sachidanandam, R. , Hannon, G. J. (2003) Free energy lights the path toward more effective RNAi. Nature Genetics, 35(4) pp. 303-305.

McCaffrey, A. P., Meuse, L., Pham, T. T. T., Conklin, D. S., Hannon, G. J. , Kay, M. A. (2002) Gene expression - RNA interference in adult mice. Nature, 418(6893) pp. 38-39.

Carmell, M. A., Xuan, Z., Zhang, M. Q. , Hannon, G. J. (2002) The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes and Development, 16(21) pp. 2733-2742.

Caudy, A. A., Myers, M., Hannon, G. J. , Hammond, S. M. (2002) Fragile X-related protein and VIG associate with the RNA interference machinery. Genes and Development, 16(19) pp. 2491-2496.

Du, J. , Hannon, G. J. (2002) The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1. Nucleic Acids Research, 30(24) pp. 5465-5475.

Ferbeyre, G., De Stanchina, E., Lin, A. W., Querido, E., McCurrach, M. E., Hannon, G. J. , Lowe, S. W. (2002) Oncogenic ras and p53 cooperate to induce cellular senescence. Molecular and Cellular Biology, 22(10) pp. 3497-3508.

Hannon, G. (2002) Mechanisms and application of RNA interference. Biology of Reproduction, 66 pp. 70-70.

Hannon, G. J. (2002) RNA interference. Nature, 418(6894) pp. 244-251.

Paddison, P. J., Caudy, A. A., Bernstein, E., Hannon, G. J. , Conklin, D. S. (2002) Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes and Development, 16(8) pp. 948-958.

Paddison, P. J., Caudy, A. A. , Hannon, G. J. (2002) Stable suppression of gene expression by RNAi in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America, 99(3) pp. 1443-1448.

Paddison, P. J. , Hannon, G. J. (2002) RNA interference: The new somatic cell genetics?. Cancer Cell, 2(1) pp. 17-23.

Seger, Y. R., García-Cao, M., Piccinin, S., Lo Cunsolo, C., Doglioni, C., Blasco, M. A., Hannon, G. J. , Maestro, R. (2002) Transformation of normal human cells in the absence of telomerase activation. Cancer Cell, 2(5) pp. 401-413.

Silva, J. M., Hammond, S. M. , Hannon, G. J. (2002) RNA interference: A promising approach to antiviral therapy?. Trends in Molecular Medicine, 8(11) pp. 505-508.

Stolarov, J., Chang, K., Reiner, A., Rodgers, L., Hannon, G. J., Wigler, M. H. , Mittal, V. (2001) Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America, 98(23) pp. 13043-13048.

Ketting, R. F., Fischer, S. E. J., Bernstein, E., Sijen, T., Hannon, G. J. , Plasterk, R. H. A. (2001) Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes and Development, 15(20) pp. 2654-2659.

Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R. , Hannon, G. J. (2001) Argonaute2, a link between genetic and biochemical analyses of RNAi. Science, 293(5532) pp. 1146-1150.

Bernstein, E., Caudy, A. A., Hammond, S. M. , Hannon, G. J. (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 409(6818) pp. 363-366.

Bernstein, E., Denli, A. M. , Hannon, G. J. (2001) The rest is silence. RNA, 7(11) pp. 1509-1521.

Hammond, S. M., Caudy, A. A. , Hannon, G. J. (2001) Post-transcriptional gene silencing by double-stranded RNA. Nature Reviews Genetics, 2(2) pp. 110-119.

Wang, J., Hannon, G. J. , Beach, D. H. (2000) Risky immortalization by telomerase. Nature, 405(6788) pp. 755-756.

Carnero, A., Hudson, J. D., Hannon, G. J. , Beach, D. H. (2000) Loss-of-function genetics in mammalian cells: The p53 tumor suppressor model. Nucleic Acids Research, 28(11) pp. 2234-2241.

Hammond, S. M., Bernstein, E., Beach, D. , Hannon, G. J. (2000) An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature, 404(6775) pp. 293-296.

Wang, J., Hannon, G. J. , Beach, D. H. (2000) Risky immortalization by telomerase. Nature, 405(6788) pp. 755-756.

Maestro, R., Dei Tos, A. P., Hamamori, Y., Krasnokutsky, S., Sartorelli, V., Kedes, L., Doglioni, C., Beach, D. H. , Hannon, G. J. (1999) Twist is a potential oncogene that inhibits apoptosis. Genes and Development, 13(17) pp. 2207-17.

Hannon, G. J., Sun, P., Carnero, A., Xie, L. Y., Maestro, R., Conklin, D. S. , Beach, D. (1999) MaRX: an approach to genetics in mammalian cells. Science, 283(5405) pp. 1129-30.

Hudson, J. D., Shoaibi, M. A., Maestro, R., Carnero, A., Hannon, G. J. , Beach, D. H. (1999) A proinflammatory cytokine inhibits p53 tumor suppressor activity. Journal of Experimental Medicine, 190(10) pp. 1375-1382.

Sun, P., Dong, P., Dai, K., Hannon, G. J. , Beach, D. (1998) p53-independent role of MDM2 in TGF-beta1 resistance. Science, 282(5397) pp. 2270-2.

LaMontagne, K. R., Hannon, G. , Tonks, N. K. (1998) Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of Rat-1 fibroblasts and promotes differentiation of K562 cells. Proceedings of the National Academy of Sciences of the United States of America, 95(24) pp. 14094-14099.

Carnero, A. , Hannon, G. J. (1998) The INK4 family of CDK inhibitors. Current Topics in Microbiology and Immunology, 227 pp. 43-55.

Fearnhead, H. O., Rodriguez, J., Govek, E. E., Guo, W., Kobayashi, R., Hannon, G. , Lazebnik, Y. A. (1998) Oncogene-dependent apoptosis is mediated by caspase-9. Proc Natl Acad Sci U S A, 95(23) pp. 13664-13669.

Wang, J., Xie, L. Y., Allan, S., Beach, D. , Hannon, G. J. (1998) Myc activates telomerase. Genes and Development, 12(12) pp. 1769-1774.

Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D. , Barrett, J. C. (1996) Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America, 93(24) pp. 13742-13747.

Balbín, M., Hannon, G. J., Pendás, A. M., Ferrando, A. A., Vizoso, F., Fueyo, A. , López-Otín, C. (1996) Functional analysis of a p21(WAF1,CIP1,SDI1) mutant (Arg 94 → Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases. Journal of Biological Chemistry, 271(26) pp. 15782-15786.

Li, Rong, Hannon, G. J., Beach, D. , Stillman, B. (1996) Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Current Biology, 6(2) pp. 189-199.

Terry, L. A., Boyd, J., Alcorta, D., Lyon, T., Solomon, G., Hannon, G., Berchuck, A., Beach, D. , Barrett, J. C. (1996) Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines. Molecular Carcinogenesis, 16(4) pp. 221-228.

Xie, Q., Sanz-Burgos, A. P., Hannon, G. J. , Gutiérrez, C. (1996) Plant cells contain a novel member of the retinoblastoma family of growth regulatory proteins. EMBO Journal, 15(18) pp. 4900-4908.

Zhou, X., Suzuki, H., Lei, J., Cole, K., Yin, J., Suzuki, Y., Abraham, J. M., Shimada, Y., Imamura, M., Chan, T., Hannon, G. J. , Meltzer, S. J. (1996) Growth suppression of esophageal cancer cells by p16 INK4 and p15 INK4B in vitro. Cancer Journal from Scientific American, 2(4) pp. 221-224.

Bruarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T. , Hannon, G. J. (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature, 377(6549) pp. 552-557.

Demetrick, D. J., Matsumoto, S., Hannon, G. J., Okamoto, K., Xiong, Y., Zhang, H. , Beach, D. H. (1995) Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). Cytogenetics and Cell Genetics, 69(3-4) pp. 190-192.

Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D. , Lassar, A. B. (1995) Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science, 267(5200) pp. 1018-1021.

Macleod, K. F., Sherry, N., Hannon, G., Beach, D., Tokino, T., Kinzler, K., Vogelstein, B. , Jacks, T. (1995) p53-Dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes and Development, 9(8) pp. 935-944.

Okamoto, A., Hussain, S. P., Hagiwara, K., Spillare, E. A., Rusin, M. R., Demetrick, D. J., Serrano, M., Hannon, G. J., Shiseki, M., Zariwala, M., Xiong, Y., Beach, D. H., Yokota, J. , Harris, C. C. (1995) Mutations in the p16(INK4)/MTS1/CDKN2, p15(INK4B)/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Research, 55(7) pp. 1448-1451.

Orlow, I., Lacombe, L., Hannon, G. J., Serrano, M., Pellicer, I., Dalbagni, G., Reuter, V. E., Zhang, Z. F., Beach, D. , Cordon-Cardo, C. (1995) Deletion of the p16 and p15 genes in human bladder tumors. Journal of the National Cancer Institute, 87(20) pp. 1524-1529.

Quelle, D. E., Ashmun, R. A., Hannon, G. J., Rehberger, P. A., Trono, D., Richter, K. H., Walker, C., Beach, D., Sherr, C. J. , Serrano, M. (1995) Cloning and characterization of murine p16(INK4a) and p15(INK4b) genes. Oncogene, 11(4) pp. 635-645.

Ranade, K., Hussussian, C. J., Sikorski, R. S., Varmus, H. E., Goldstein, A. M., Tucker, M. A., Serrano, M., Hannon, G. J., Beach, D. , Dracopoli, N. C. (1995) Mutations associated with familial melanoma impair p16(INK4) function. Nature Genetics, 10(1) pp. 114-116.

Suzuki, H., Zhou, X., Yin, J., Lei, J., Jiang, H. Y., Suzuki, Y., Chan, T., Hannon, G. J., Mergner, W. J., Abraham, J. M. , Meltzer, S. J. (1995) Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Human Molecular Genetics, 4(10) pp. 1883-1887.

Beach, D., Serrano, M. , Hannon, G. J. (1994) P16(Ink4) - an Specific Inhibitor of the Cdk4/Cyclin-D Kinase. Journal of Cellular Biochemistry, Supp(18C) pp. 161-161.

Feilotter, H. E., Hannon, G. J., Ruddell, C. J. , Beach, D. (1994) Construction of an improved host strain for two hybrid screening. Nucleic Acids Research, 22(8) pp. 1502-1503.

Hannon, G. E., Hannon, G. J., Maroney, P. A. , Nilsen, T. W. (1994) Transcription of a nematode U1 small nuclear RNA in vitro. 3'-end formation requires cis-acting elements within the coding sequence. Journal of Biological Chemistry, 269(17) pp. 12387-12390.

Hannon, G. J. , Beach, D. (1994) p15(INK4B) is a potential effector of TGF-β-induced cell cycle arrest. Nature, 371(6494) pp. 257-261.

Hannon, G. J., Casso, D. , Beach, D. (1994) KAP: A dual specificity phosphatase that interacts with cyclin-dependent kinases. Proceedings of the National Academy of Sciences of the United States of America, 91(5) pp. 1731-1735.

Li, R., Waga, S., Hannon, G. J., Beach, D. , Stillman, B. (1994) Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature, 371(6497) pp. 534-537.

Waga, S., Hannon, G. J., Beach, D. , Stillman, B. (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature, 369(6481) pp. 574-578.

Zhang, H., Hannon, G. J. , Beach, D. (1994) p21-Containing cyclin kinases exist in both active and inactive states. Genes and Development, 8(15) pp. 1750-1758.

Zhang, H., Hannon, G. J., Casso, D. , Beach, D. (1994) p21 is a component of active cell cycle kinases. Cold Spring Harbor Symposia on Quantitative Biology, 59 pp. 21-29.

Hannon, G. J., Demetrick, D. , Beach, D. (1993) Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes and Development, 7(12 A) pp. 2378-2391.

Serrano, M., Hannon, G. J. , Beach, D. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature, 366(6456) pp. 704-707.

Xiong, Y., Hannon, G. J., Zhang, H., Casso, D., Kobayashi, R. , Beach, D. (1993) p21 is a universal inhibitor of cyclin kinases. Nature, 366(6456) pp. 701-704.

Hannon, G. J., Maroney, P. A., Yu, Y. T., Hannon, G. E. , Nilsen, T. W. (1992) Interaction of U6 snRNA with a sequence required for function of the nematode SL RNA in trans-splicing. Science, 258(5089) pp. 1775-1780.

Hannon, G. J., Chubb, A., Maroney, P. A., Hannon, G., Altman, S. , Nilsen, T. W. (1991) Multiple cis-acting elements are required for RNA polymerase III transcription of the gene encoding H1 RNA, the RNA component of human RNase P. Journal of Biological Chemistry, 266(34) pp. 22796-22799.

Hannon, G. J., Maroney, P. A. , Nilsen, T. W. (1991) U small nuclear ribonucleoprotein requirements for nematode cis- and trans-splicing in vitro. Journal of Biological Chemistry, 266(34) pp. 22792-22695.

Maroney, P. A., Hannon, G. J., Shambaugh, J. D. , Nilsen, T. W. (1991) Intramolecular base pairing between the nematode spliced leader and its 5' splice site is not essential for trans-splicing in vitro. EMBO Journal, 10(12) pp. 3869-3875.

Hannon, G. J., Maroney, P. A., Ayers, D. G., Shambaugh, J. D. , Nilsen, T. W. (1990) Transcription of a nematode trans-spliced leader RNA require internal elements for both initiation and 3' end-formation. EMBO Journal, 9(6) pp. 1915-1921.

Hannon, G. J., Maroney, P. A., Denker, J. A. , Nilsen, T. W. (1990) Trans splicing of nematode pre-messenger RNA in vitro. Cell, 61(7) pp. 1247-1255.

Maroney, P. A., Hannon, G. J., Denker, J. A. , Nilsen, T. W. (1990) The nematode spliced leader RNA participates in trans-splicing as an Sm snRNP. Embo Journal, 9(11) pp. 3667-3673.

Maroney, P. A., Hannon, G. J. , Nilsen, T. W. (1990) Transcription and cap trimethylation of a nematode spliced leader RNA in a cell-free system. Proceedings of the National Academy of Sciences of the United States of America, 87(2) pp. 709-713.

Hannon, G. J., Maroney, P. A., Branch, A., Benenfield, B. J., Robertson, H. D. , Nilsen, T. W. (1989) Accurate processing of human pre-rRNA in vitro. Molecular and Cellular Biology, 9(10) pp. 4422-4431.

Maroney, P. A., Hannon, G. J. , Nilsen, T. W. (1989) Accurate and efficient RNA polymerase III transcription in a cell-free extract prepared from Ascaris suum embryos. Molecular and Biochemical Parasitology, 35(3) pp. 277-283.

Ransohoff, R. M., Denker, J. A., Takacs, A. M., Hannon, G. J. , Nilsen, T. W. (1989) Organization and expression of 5S rRNA genes in the parasitic nematode,Brugia malayi. Nucleic Acids Research, 17(10) pp. 3773-3782.

Hannon, G. J. , Jentoft, J. E. (1985) MOLECULAR DESIGNER: An interactive program for the display of protein structure on the IBM-PC. Computer Applications in the Biosciences, 1(3) pp. 177-181.