Additional materials of the author at
CSHL Institutional Repository

Jain, Anant, Nakahata, Yoshihisa, Watabe, Tetsuya, Rusina, Polina, South, Kelly, Adachi, Kengo, Yan, Long, Simorowski, Noriko, Furukawa, Hiro , Yasuda, Ryohei (2023) Dendritic, delayed, and stochastic CaMKII activation underlies behavioral time scale plasticity in CA1 synapses.

Syrjänen, Johanna L, Epstein, Max, Gómez, Ricardo , Furukawa, Hiro (2023) Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red. Nature Communications, 14(1) pp. 3821.

Harris, Lynnea D, Regan, Michael C, Myers, Scott J, Nocilla, Kelsey A, Akins, Nicholas S, Tahirovic, Yesim A, Wilson, Lawrence J, Dingledine, Ray, Furukawa, Hiro, Traynelis, Stephen F , Liotta, Dennis C (2023) Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model. ACS Chemical Neuroscience,

Yovanno, Remy A, Chou, Tsung Han, Brantley, Sarah J, Furukawa, Hiro , Lau, Albert Y (2022) Excitatory and inhibitory D-serine binding to the NMDA receptor. eLife, 11 pp. e77645.

Chou, Tsung-Han, Kang, Hyunook, Simorowski, Noriko, Traynelis, Stephen F , Furukawa, Hiro (2022) Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Molecular Cell, pp. S1097-2765(22)00965.

Steigerwald, Ruben, Chou, Tsung-Han, Furukawa, Hiro , Wünsch, Bernhard (2022) GluN2A-selective NMDA receptor antagonists: Mimicking the U-shaped bioactive conformation of TCN-201 by a [2.2]paracyclophane system. ChemMedChem: chemistry enabling drug discovery,

Chou, Tsung-Han, Epstein, Max, Michalski, Kevin, Fine, Eve, Biggin, Philip C , Furukawa, Hiro (2022) Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nature Structural and Molecular Biology,

Tajima, Nami, Simorowski, Noriko, Yovanno, Remy A, Regan, Michael C, Michalski, Kevin, Gómez, Ricardo, Lau, Albert Y , Furukawa, Hiro (2022) Development and characterization of functional antibodies targeting NMDA receptors. Nature Communications, 13(1) pp. 923.

Yovanno, Remy, Chou, Tsung Han, Brantley, Sarah, Furukawa, Hiro , Lau, Albert (2022) Excitatory and inhibitory D-serine binding to the NMDA receptor. bioRxiv,

Hansen, Kasper B, Wollmuth, Lonnie P, Bowie, Derek, Furukawa, Hiro, Menniti, Frank S, Sobolevsky, Alexander I, Swanson, Geoffrey T, Swanger, Sharon A, Greger, Ingo H, Nakagawa, Terunaga, McBain, Chris J, Jayaraman, Vasanthi, Low, Chian-Ming, Dell'Acqua, Mark L, Diamond, Jeffrey S, Camp, Chad R, Perszyk, Riley E, Yuan, Hongjie , Traynelis, Stephen F (2021) Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacological Reviews, 73(4) pp. 298-487.

Syrjanen, Johanna, Michalski, Kevin, Kawate, Toshimitsu , Furukawa, Hiro (2021) On the molecular nature of large-pore channels.. Journal of Molecular Biology, pp. 166994.

Perszyk, R. E., Myers, S. J., Yuan, H., Gibb, A. J., Furukawa, H., Sobolevsky, A. I. , Traynelis, S. F. (2020) Hodgkin-Huxley-Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif. J Physiol, 598(15) pp. 3071-3083.

Chou, Tsung-Han, Tajima, Nami, Romero-Hernandez, Annabel , Furukawa, Hiro (2020) Structural Basis of Functional Transitions in Mammalian NMDA Receptors.. Cell, 182(2) pp. 357-371.e13.

Syrjanen, Johanna L, Michalski, Kevin, Chou, Tsung-Han, Grant, Timothy, Rao, Shanlin, Simorowski, Noriko, Tucker, Stephen J, Grigorieff, Nikolaus , Furukawa, Hiro (2020) Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins.. Nature Structural and Molecular Biology, 27(3) pp. 305.

Michalski, K., Syrjanen, J. L., Henze, E., Kumpf, J., Furukawa, H. , Kawate, T. (2020) The cryo-EM structure of a pannexin 1 reveals unique motifs for ion selection and inhibition. Elife, 9

Syrjanen, J. L., Michalski, K., Chou, T. H., Grant, T., Rao, S., Simorowski, N., Tucker, S. J., Grigorieff, N. , Furukawa, H. (2020) Structure and assembly of calcium homeostasis modulator proteins. Nat Struct Mol Biol, 27(2) pp. 150-159.

Wang, J. X., Irvine, M. W., Burnell, E. S., Sapkota, K., Thatcher, R. J., Li, M., Simorowski, N., Volianskis, A., Collingridge, G. L., Monaghan, D. T., Jane, D. E. , Furukawa, H. (2020) Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nat Commun, 11(1) pp. 423.

Wang, J. X. , Furukawa, H. (2019) Dissecting diverse functions of NMDA receptors by structural biology. Curr Opin Struct Biol, 54 pp. 34-42.

Regan, M. C., Zhu, Z., Yuan, H., Myers, S. J., Menaldino, D. S., Tahirovic, Y. A., Liotta, D. C., Traynelis, S. F. , Furukawa, H. (2019) Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors. Nat Commun, 10(1) pp. 321.

Syrjanen, Johanna, Michalski, Kevin, Chou, Tsung-Han, Grant, Timothy, Rao, Shanlin, Simorowski, Noriko, Tucker, Stephen, Grigorieff, Nikolaus , Furukawa, Hiro (2019) Structure and assembly of calcium homeostasis modulator proteins. Nature Structural and Molecular Biology,

Hansen, K. B., Yi, F., Perszyk, R. E., Furukawa, H., Wollmuth, L. P., Gibb, A. J. , Traynelis, S. F. (2018) Structure, function, and allosteric modulation of NMDA receptors. J Gen Physiol,

Regan, M. C., Grant, T., McDaniel, M. J., Karakas, E., Zhang, J., Traynelis, S. F., Grigorieff, N. , Furukawa, H. (2018) Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron, 98(3) pp. 521-529.

Wu, Q., Regan, M., Furukawa, H. , Jackson, D. (2018) Role of heterotrimeric Galpha proteins in maize development and enhancement of agronomic traits. PLoS Genet, 14(4) pp. e1007374.

Elegheert, Jonathan, Cvetkovska, Vedrana, Clayton, Amber J, Heroven, Christina, Vennekens, Kristel M, Smukowski, Samuel N, Regan, Michael C, Jia, Wanyi, Smith, Alexandra C, Furukawa, Hiro, Savas, Jeffrey N, de Wit, Joris, Begbie, Jo, Craig, Ann Marie , Aricescu, A Radu (2017) Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.. Neuron, 96(1) pp. 242-244.

Elegheert, Jonathan, Cvetkovska, Vedrana, Clayton, Amber J., Heroven, Christina, Vennekens, Kristel M., Smukowski, Samuel N., Regan, Michael C., Jia, Wanyi, Smith, Alexandra C., Furukawa, Hiro, Savas, Jeffrey N., de Wit, Joris, Begbie, Jo, Craig, Ann Marie , Aricescu, A. Radu (2017) Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron, 95(4) pp. 896-913.e10.

Romero-Hernandez, A. , Furukawa, H. (2017) Novel mode of antagonist binding in NMDA receptors revealed by the crystal structure of the GluN1-GluN2A ligand-binding domain complexed to NVP-AAM077. Mol Pharmacol, 92(1) pp. 22-29.

Amin, J. B., Salussolia, C. L., Chan, K., Regan, M. C., Dai, J., Zhou, H. X., Furukawa, H., Bowen, M. E. , Wollmuth, L. P. (2017) Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors. J Gen Physiol, 149(6) pp. 661-680.

Romero-Hernandez, Annabel, Simorowski, Noriko, Karakas, Erkan , Furukawa, Hiro (2016) Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain. Neuron, 92(6) pp. 1324-1336.

Regan, Michael C. , Furukawa, Hiro (2016) Deeper Insights into the Allosteric Modulation of Ionotropic Glutamate Receptors. Neuron, 91(6) pp. 1187-1189.

Malinauskas, Tomas , Furukawa, Hiro (2016) Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry.. Structure, 24(6) pp. 1008-1009.

Malinauskas, Tomas , Furukawa, Hiro (2016) Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry. Structure, 24(5) pp. 653-655.

Tajima, N., Karakas, E., Grant, T., Simorowski, N., Diaz-Avalos, R., Grigorieff, N. , Furukawa, H. (2016) Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Nature, 534(7605) pp. 63-8.

Regan, Michael C., Romero-Hernandez, Annabel , Furukawa, Hiro (2015) A structural biology perspective on NMDA receptor pharmacology and function. Current Opinion in Structural Biology, 33 pp. 68-75.

Karakas, Erkan, Regan, Michael C. , Furukawa, Hiro (2015) Emerging structural insights into the function of ionotropic glutamate receptors. Trends in Biochemical Sciences, 40(6) pp. 328-337.

Khatri, A., Burger, P. B., Swanger, S. A., Hansen, K. B., Zimmerman, S., Karakas, E., Liotta, D. C., Furukawa, H., Snyder, J. P. , Traynelis, S. F. (2014) Structural Determinants and Mechanism of Action of a GluN2C-selective NMDA Receptor Positive Allosteric Modulator. Mol Pharmacol, 86(5) pp. 548-560.

Karakas, E. , Furukawa, H. (2014) Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344(6187) pp. 992-7.

Jespersen, A., Tajima, N., Fernandez-Cuervo, G., Garnier-Amblard, E. C. , Furukawa, H. (2014) Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81(2) pp. 366-78.

Hansen, K. B., Tajima, N., Risgaard, R., Perszyk, R. E., Jorgensen, L., Vance, K. M., Ogden, K. K., Clausen, R. P., Furukawa, H. , Traynelis, S. F. (2013) Structural determinants of agonist efficacy at the glutamate binding site of n-methyl-d-Aspartate receptorss. Molecular Pharmacology, 84(1) pp. 114-127.

Salussolia, C. L., Gan, Q., Kazi, R., Singh, P., Allopenna, J., Furukawa, H. , Wollmuth, L. P. (2013) A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors. Journal of Neuroscience, 33(23) pp. 9840-9845.

Burger, P. B., Yuan, H. J., Karakas, E., Geballe, M., Furukawa, H., Liotta, D. C., Snyder, J. P. , Traynelis, S. F. (2012) Mapping the Binding of GluN2B-Selective N-Methyl-D-aspartate Receptor Negative Allosteric Modulators. Molecular Pharmacology, 82(2) pp. 344-359.

Furukawa, H. (2012) Structure and function of glutamate receptor amino terminal domains. Journal of Physiology, 590(1) pp. 63-72.

Karakas, E., Simorowski, N. , Furukawa, H. (2011) Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature, 475(7355) pp. 249- U170.

Vance, K. M., Simorowski, N., Traynelis, S. F. , Furukawa, H. (2011) Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nature Communications, 2

Hansen, K. B., Furukawa, H. , Traynelis, S. F. (2010) Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain. Molecular Pharmacology, 78(4) pp. 535-549.

Karakas, Erkan, Simorowski, Noriko , Furukawa, Hiro (2010) Structural Insights into Allosteric Modulation of NMDA Receptors Through the Amino-Terminal Domain. Biophysical Journal, 98(3, Sup) pp. 609a-609a.

Karakas, E., Simorowski, N. , Furukawa, H. (2009) Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. Embo Journal, 28(24) pp. 3910-3920.

Jin, R., Singh, S. K., Gu, S., Furukawa, H., Sobolevsky, A. I., Zhou, J., Jin, Y. , Gouaux, E. (2009) Crystal structure and association behaviour of the GluR2 amino-terminal domain. Embo J, 28(12) pp. 1812-23.

Jasti, J., Furukawa, H., Gonzales, E. B. , Gouaux, E. (2007) Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature, 449(7160) pp. 316-23.

Vasquez, V., Cortes, D. M., Furukawa, H. , Perozo, E. (2007) An optimized purification and reconstitution method for the MscS channel: strategies for spectroscopical analysis. Biochemistry, 46(23) pp. 6766-73.

Takahashi, H., Shin, Y., Cho, S. J., Zago, W. M., Nakamura, T., Gu, Z., Ma, Y., Furukawa, H., Liddington, R., Zhang, D., Tong, G., Chen, H. S. , Lipton, S. A. (2007) Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif. Neuron, 53(1) pp. 53-64.

Furukawa, H., Singh, S. K., Mancusso, R. , Gouaux, E. (2005) Subunit arrangement and function in NMDA receptors. Nature, 438(7065) pp. 185-192.

Inanobe, A., Furukawa, H. , Gouaux, E. (2005) Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron, 47(1) pp. 71-84.

Furukawa, H. , Gouaux, E. (2003) Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. Embo J, 22(12) pp. 2873-85.

Furukawa, H., Hamada, T., Hayashi, M. K., Haga, T., Muto, Y., Hirota, H., Yokoyama, S., Nagasawa, K. , Ishiguro, M. (2002) Conformation of ligands bound to the muscarinic acetylcholine receptor. Mol Pharmacol, 62(4) pp. 778-87.

Furukawa, H. , Haga, T. (2000) Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli. J Biochem, 127(1) pp. 151-61.