Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy

Grabenstetter, Anne, Brogi, Edi, Zhang, Hong, Razavi, Pedram, Reis-Filho, Jorge S, VanZee, Kimberly J, Norton, Larry, Wen, Hannah Y (August 2022) Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy. npj Breast Cancer, 8 (1). p. 93. ISSN 2374-4677

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Abstract

Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC). Recent studies have shown that the SB-AdCC variant has significantly worse prognosis than C-AdCC. Due to the rarity of SB-AdCC, no standard recommendations are available for its management. Data on the use and benefit of chemotherapy in patients with SB-AdCC are sparse and the response to neoadjuvant chemotherapy has not been reported. We present the clinical and pathologic findings of a patient with SB-AdCC treated with neoadjuvant chemotherapy who achieved a remarkable pathologic response.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders diseases & disorders > cancer > cancer types > breast cancer diseases & disorders > cancer > cancer types
CSHL Authors:	Norton, Larry
Communities:	CSHL labs > Wigler lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	11 August 2022
Date Deposited:	08 Sep 2022 22:02
Last Modified:	11 Jan 2024 20:22
PMCID:	PMC9372162
URI:	https://repository.cshl.edu/id/eprint/40712

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