Valentino, Rita J, Guyenet, Patrice, Hou, Xun Helen, Herman, Melissa (November 2017) Central Network Dynamics Regulating Visceral and Humoral Functions. The Journal of Neuroscience, 37 (45). pp. 10848-10854. ISSN 0270-6474
Abstract
The brain processes information from the periphery and regulates visceral and immune activity to maintain internal homeostasis, optimally respond to a dynamic external environment, and integrate these functions with ongoing behavior. In addition to its relevance for survival, this integration underlies pathology as evidenced by diseases exhibiting comorbid visceral and psychiatric symptoms. Advances in neuroanatomical mapping, genetically specific neuronal manipulation, and neural network recording are overcoming the challenges of dissecting complex circuits that underlie this integration and deciphering their function. Here we focus on reciprocal communication between the brain and urological, gastrointestinal, and immune systems. These studies are revealing how autonomic activity becomes integrated into behavior as part of a social strategy, how the brain regulates innate immunity in response to stress, and how drugs impact emotion and gastrointestinal function. These examples highlight the power of the functional organization of circuits at the interface of the brain and periphery.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell neurobiology > neuroscience neurobiology > neuroscience > systems neuroscience |
| CSHL Authors: | |
| Communities: | CSHL labs > Hou lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 8 November 2017 |
| Date Deposited: | 10 May 2022 14:12 |
| Last Modified: | 10 May 2022 14:12 |
| PMCID: | PMC5678017 |
| URI: | https://repository.cshl.edu/id/eprint/40605 |
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