Continuous Flow Synthesis of Secondary Amides by Tandem Azidation-Amidation of Anilines

Spiteri, Christian, Moses, John E (June 2012) Continuous Flow Synthesis of Secondary Amides by Tandem Azidation-Amidation of Anilines. Synlett: accounts and rapid communications in synthetic organic chemistry, 23 (10). pp. 1546-1548. ISSN 0936-5214

DOI: 10.1055/s-0031-1291013

Abstract

The continuous flow synthesis of a variety of secondary amides by tandem azidation-amidation of anilines is described. This new procedure benefits from the improved safety feature of generating aromatic azides in flow, thus ensuring low concentrations of any potentially hazardous intermediates. The protocol was amenable to the production of multi-gram quantities of the amide product. © Georg Thieme Verlag Stuttgart · New York.

Item Type: Paper
Subjects: chemistry > chemicals > aromatic azides
chemistry > chemical synthesis
chemistry > techniques > microwaves
CSHL Authors:
Communities: CSHL labs > Moses lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: June 2012
Date Deposited: 06 Jul 2021 20:48
Last Modified: 06 Jul 2021 20:48
Related URLs:
URI: https://repository.cshl.edu/id/eprint/40250

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