Small RNAs guide histone methylation in Arabidopsis embryos

Parent, Jean-Sébastien, Cahn, Jonathan, Herridge, Rowan P, Grimanelli, Daniel, Martienssen, Robert A (June 2021) Small RNAs guide histone methylation in Arabidopsis embryos. Genes and Development. ISSN 0890-9369

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Abstract

Epigenetic reprogramming occurs during gametogenesis as well as during embryogenesis to reset the genome for early development. In flowering plants, many heterochromatic marks are maintained in sperm, but asymmetric DNA methylation is mostly lost. Asymmetric DNA methylation is dependent on small RNA but the re-establishment of silencing in embryo is not well understood. Here we demonstrate that small RNAs direct the histone H3 lysine 9 dimethylation during Arabidopsis thaliana embryonic development, together with asymmetric DNA methylation. This de novo silencing mechanism depends on the catalytic domain of SUVH9, a Su(Var)3-9 homolog thought to be catalytically inactive.

Item Type:	Paper
Subjects:	organism description > plant > Arabidopsis bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA methylation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein methylation > histone methylation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression > transposable elements
CSHL Authors:	Martienssen, Robert A. Grimanelli, Daniel Herridge, Rowan Parent, Jean-Sebastien
Communities:	CSHL labs > Martienssen lab CSHL Cancer Center Program CSHL Cancer Center Program > Gene Regulation and Inheritance Program CSHL Cancer Center Shared Resources
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	1 June 2021
Date Deposited:	26 May 2021 15:18
Last Modified:	13 Feb 2024 19:12
PMCID:	PMC8168562
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/40170

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