Distribution and storage of inflammatory memory in barrier tissues

Ordovas-Montanes, J., Beyaz, S., Rakoff-Nahoum, S., Shalek, A. K. (February 2020) Distribution and storage of inflammatory memory in barrier tissues. Nat Rev Immunol, 20 (5). pp. 308-320. ISSN 1474-1733

URL: https://www.ncbi.nlm.nih.gov/pubmed/32015472
DOI: 10.1038/s41577-019-0263-z

Abstract

Memories of previous immune events enable barrier tissues to rapidly recall distinct environmental exposures. To effectively inform future responses, these past experiences can be stored in cell types that are long-term residents or essential constituents of tissues. There is an emerging understanding that, in addition to antigen-specific immune cells, diverse haematopoietic, stromal, parenchymal and neuronal cell types can store inflammatory memory. Here, we explore the impact of previous immune activity on various cell lineages with the goal of presenting a unified view of inflammatory memory to environmental exposures (such as allergens, antigens, noxious agents and microorganisms) at barrier tissues. We propose that inflammatory memory is distributed across diverse cell types and stored through shifts in cell states, and we provide a framework to guide future experiments. This distribution and storage may promote adaptation or maladaptation in homeostatic, maintenance and disease settings - especially if the distribution of memory favours cellular cooperation during storage or recall.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
diseases & disorders > inflammation
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL Cancer Center Program > Cellular Communication in Cancer Program
CSHL labs > Beyaz lab
Depositing User: Adrian Gomez
Date: 3 February 2020
Date Deposited: 10 Feb 2020 14:49
Last Modified: 29 Jun 2021 16:12
PMCID: PMC7547402
Related URLs:
URI: https://repository.cshl.edu/id/eprint/38964

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