DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency

Tsaniras, S. C., Delinasios, G. J., Petropoulos, M., Panagopoulos, A., Anagnostopoulos, A. K., Villiou, M., Vlachakis, D., Bravou, V., Stathopoulos, G. T., Taraviras, S. (November 2019) DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency. Cancer Genomics Proteomics, 16 (6). pp. 593-601. ISSN 1109-6535

URL: https://www.ncbi.nlm.nih.gov/pubmed/31659113http:/...
DOI: 10.21873/cgp.20162

Abstract

BACKGROUND/AIM: Several links between DNA replication, pluripotency and development have been recently identified. The involvement of miRNA in the regulation of cell cycle events and pluripotency factors has also gained attention. MATERIALS AND METHODS: In the present study, we used the g:Profiler platform to analyze transcription factor binding sites, miRNA networks and protein-protein interactions to identify novel links among the aforementioned processes. RESULTS AND CONCLUSION: A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a central role in this circuitry.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA regulation
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > pluripotency
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Depositing User: Matthew Dunn
Date: November 2019
Date Deposited: 08 Nov 2019 17:46
Last Modified: 08 Nov 2019 17:46
Related URLs:
URI: https://repository.cshl.edu/id/eprint/38667

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