Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-delta Pathway

Beyaz, S., Yilmaz, O. H. (December 2016) Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-delta Pathway. Clin Cancer Res, 22 (23). pp. 5636-5641. ISSN 1078-0432 (Print)1078-0432 (Linking)

DOI: 10.1158/1078-0432.CCR-16-0775


Peroxisome proliferator-activated receptor delta (PPAR-delta) is a nuclear receptor transcription factor that regulates gene expression during development and disease states, such as cancer. However, the precise role of PPAR-delta during tumorigenesis is not well understood. Recent data suggest that PPAR-delta may have context-specific oncogenic and tumor-suppressive roles depending on the tissue, cell-type, or diet-induced physiology in question. For example, in the intestine, pro-obesity diets, such as a high-fat diet (HFD), are associated with increased colorectal cancer incidence. Interestingly, many of the effects of an HFD in the stem and progenitor cell compartment are driven by a robust PPAR-delta program and contribute to the early steps of intestinal tumorigenesis. Importantly, the PPAR-delta pathway or its downstream mediators may serve as therapeutic intervention points or biomarkers in colon cancer that arise in patients who are obese. Although potent PPAR-delta agonists and antagonists exist, their clinical utility may be enhanced by uncovering how PPAR-delta mediates tumorigenesis in diverse tissues and cell types as well as in response to diet. Clin Cancer Res; 22(23); 5636-41. (c)2016 AACR.

Item Type: Paper
Uncontrolled Keywords: Animals Carcinogenesis/*metabolism/*pathology Diet, High-Fat/adverse effects Humans Intestines/metabolism/pathology Neoplasms/*metabolism/pathology PPAR delta/*metabolism Signal Transduction/*physiology Stem Cells/*metabolism/pathology
Subjects: diseases & disorders > cancer
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
CSHL Authors:
Communities: CSHL labs > Beyaz lab
Depositing User: Matt Covey
Date: 1 December 2016
Date Deposited: 01 Feb 2018 21:41
Last Modified: 01 Feb 2018 21:41
PMCID: PMC5135602
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