Efrat, S., Hanahan, D. (1989) Evidence for Threshold Effects in Transformation of Pancreatic Beta-Cells by Sv40 T-Antigen in Transgenic Mice. Current Topics in Microbiology and Immunology, 144. pp. 89-95. ISSN 0070-217X
Abstract
Transgenic mice harboring hybrid insulin-T antigen genes manifest heritable patterns of tumor formation (Hanahan 1985; Efrat and Hanahan 1987; Adams et al. 1987; Teitelman et al. 1988). In all mice inheriting the hybrid oncogene, denoted RIP1-Tag, its cell-specific expression in ß cells in all the pancreatic islets of Langerhans causes ß-cell transformation and proliferation, which results in islet hyperplasia. This is followed by development of only a few islets into solid, vascularized tumors and consequent premature death. It thus appears that T antigen is necessary but not sufficient for tumor formation and that additional events may be required.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | CELLULAR TUMOR-ANTIGEN P53 GENE INSULIN EXPRESSION PROTEIN REGION |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > pancreatic stellate cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > pancreatic stellate cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > pancreatic stellate cells bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Gail Sherman |
| Date: | 1989 |
| Date Deposited: | 28 Jul 2017 16:18 |
| Last Modified: | 28 Jul 2017 16:18 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34845 |
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