ROS in translation: Chink in the armor

Chio, II, Tuveson, D. A. (January 2017) ROS in translation: Chink in the armor. Cell Cycle, 16 (4). pp. 297-298. ISSN 1551-4005

DOI: 10.1080/15384101.2016.1232087


Pancreatic ductal adenocarcinoma (PDA) holds the most dismal prognosis among the common malignancies and is considered to be largely incurable. In spite of extensive efforts in preclinical and clinical science, the survival rate of pancreatic cancer has not improved substantially over the past 40 y. An activating mutation of KRAS is the most common genetic perturbation found in PDA, occurring in 90-95% of the cases. Despite the identification of a clear driver oncogene, clinically actionable strategies to target KRAS have not yet been identified. A deeper understanding of the molecular events downstream of KRAS is therefore critical for the development of new therapeutic interventions for this deadly disease.

Item Type: Paper
Uncontrolled Keywords: Nrf2 cysteine thiols pancreatic cancer protein synthesis redox homeostasis
Subjects: diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL Cancer Center Program > Signal Transduction
CSHL labs > Tuveson lab
CSHL Cancer Center Program > Cellular Communication in Cancer Program
Depositing User: Matt Covey
Date: 27 January 2017
Date Deposited: 16 Feb 2017 17:20
Last Modified: 22 Oct 2020 20:38
PMCID: PMC5388435
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