Sheltzer, J. M., Amon, A. (November 2011) The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet, 27 (11). pp. 446-53. ISSN 0168-9525 (Print)0168-9525 (Linking)
Abstract
Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date, aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also a hallmark of cancer, a disease of enhanced proliferative capacity, and aneuploid cells are frequently recovered following the experimental evolution of microorganisms. Thus, in certain contexts, aneuploidy might also have growth-advantageous properties. New models of aneuploidy and chromosomal instability have shed light on the diverse effects that karyotypic imbalances have on cellular phenotypes, and suggest novel ways of understanding the role of aneuploidy in development and disease.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | *Aneuploidy *Cell Proliferation Cost-Benefit Analysis Diagnostic Errors/*economics Genetic Diseases, Inborn/diagnosis/genetics Genetic Fitness/physiology Humans Karyotype Karyotyping/*economics/*utilization Models, Biological |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomal duplications > aneuploidy organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation |
| CSHL Authors: | |
| Communities: | CSHL labs > Sheltzer lab |
| Depositing User: | Matt Covey |
| Date: | November 2011 |
| Date Deposited: | 10 Sep 2015 18:59 |
| Last Modified: | 10 Sep 2015 18:59 |
| PMCID: | PMC3197822 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31749 |
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