Apoptosis: A link between cancer genetics and chemotherapy

Johnstone, R. W., Ruefli, A. A., Lowe, S. W. (January 2002) Apoptosis: A link between cancer genetics and chemotherapy. Cell, 108 (2). pp. 153-164. ISSN 0092-8674

URL: http://www.ncbi.nlm.nih.gov/pubmed/11832206
DOI: 10.1016/S0092-8674(02)00625-6


Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
diseases & disorders > cancer > drugs and therapies > chemotherapy
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Matt Covey
Date: January 2002
Date Deposited: 08 Jan 2014 17:03
Last Modified: 08 Jan 2014 17:03
Related URLs:
URI: https://repository.cshl.edu/id/eprint/28727

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