Lin, W., Piskol, R., Tan, M. H., Li, J. B. (March 2012) Comment on "Widespread RNA and DNA sequence differences in the human transcriptome". Science, 335 (6074). 1302; author reply 1302. ISSN 1095-9203 (Electronic)0036-8075 (Linking)
Abstract
Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics organism description > animal > mammal > primates > hominids > human organism description > animal > mammal bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transcriptomes |
| CSHL Authors: | |
| Communities: | CSHL labs > Gingeras lab |
| Depositing User: | Matt Covey |
| Date: | 16 March 2012 |
| Date Deposited: | 30 Jan 2013 17:46 |
| Last Modified: | 30 Jan 2013 17:46 |
| PMCID: | NLM |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26995 |
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