Evolution of Arabidopsis microRNA families through duplication events

Maher, C., Stein, L. D., Ware, D. (April 2006) Evolution of Arabidopsis microRNA families through duplication events. Genome Res, 16 (4). pp. 510-9. ISSN 1088-9051 (Print)

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Abstract

Recently there has been a great interest in the identification of microRNAs and their targets as well as understanding the spatial and temporal regulation of microRNA genes. To understand how microRNA genes evolve, we looked at several rapidly evolving families in Arabidopsis thaliana, and found that they arose from a process of genome-wide duplication, tandem duplication, and segmental duplication followed by dispersal and diversification, similar to the processes that drive the evolution of protein gene families. Using multiple expression data sets to examine the transcription patterns of different members of the microRNA families, we find the sequence diversification of duplicated microRNA genes to be accompanied by a change in spatial and temporal expression patterns, suggesting that duplicated copies acquire new functionality as they evolve.

Item Type:	Paper
Uncontrolled Keywords:	Arabidopsis genetics Evolution Molecular Gene Duplication Genes Plant genetics MicroRNAs genetics RNA Plant genetics
Subjects:	organism description > plant > Arabidopsis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomal duplications bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mRNA dynamics
CSHL Authors:	Maher, Christopher Stein, Lincoln D. Ware, Doreen H.
Communities:	CSHL labs > Stein lab CSHL labs > Ware lab
Depositing User:	CSHL Librarian
Date:	April 2006
Date Deposited:	12 Dec 2011 17:13
Last Modified:	06 Nov 2017 17:19
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/22855

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