Lippman, Z., Martienssen, R. A.
(September 2004)
The role of RNA interference in heterochromatic silencing.
Nature, 431 (7006).
pp. 364-70.
ISSN 1476-4687 (Electronic)
Abstract
Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution.
| Item Type: |
Paper
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| Uncontrolled Keywords: |
Animals
Gene Expression Regulation Plant
Genomic Imprinting genetics
Heterochromatin genetics metabolism
RNA Interference physiology
Repetitive Sequences Nucleic Acid genetics
Yeasts genetics |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene silencing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics > heterochromatin |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Lippman lab
CSHL labs > Martienssen lab
School of Biological Sciences > Publications |
| Depositing User: |
CSHL Librarian
|
| Date: |
16 September 2004 |
| Date Deposited: |
31 Jan 2012 20:06 |
| Last Modified: |
19 Sep 2014 15:02 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/22425 |
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