ErbB receptors and cell polarity: New pathways and paradigms for understanding cell migration and invasion

Feigin, M. E., Muthuswamy, S. K. (February 2008) ErbB receptors and cell polarity: New pathways and paradigms for understanding cell migration and invasion. Experimental Cell Research, 315 (4). pp. 707-716. ISSN 0014-4827

URL: https://www.ncbi.nlm.nih.gov/pubmed/19022245
DOI: 10.1016/j.yexcr.2008.10.034

Abstract

The ErbB family of receptor tyrosine kinases is involved in initiation and progression of a number of human cancers, and receptor activation or overexpression correlates with poor patient survival. Research over the past two decades has elucidated the molecular mechanisms underlying ErbB-induced tumorigenesis, which has resulted in the development of effective targeted therapies. ErbB-induced signal transduction cascades regulate a wide variety of cell processes, including cell proliferation, apoptosis, cell polarity, migration and invasion. Within tumors, disruption of these core processes, through cooperative oncogenic lesions, results in aggressive, metastatic disease. This review will focus on the ErbB signaling networks that regulate migration and invasion and identify a potential role for cell polarity pathways during cancer progression.

Item Type: Paper
Uncontrolled Keywords: ErbB Cell polarity Migration Invasion Metastasis Signaling Cell architecture
Subjects: bioinformatics > genomics and proteomics > analysis and processing > molecular interaction processing
bioinformatics > genomics and proteomics > analysis and processing > NETBAG
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diseases & disorders > cancer > cancer types > breast cancer
organism description > animal > mammal > primates > hominids > human
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
Depositing User: Tom Adams
Date: 15 February 2008
Date Deposited: 14 Jul 2011 20:46
Last Modified: 14 Mar 2018 15:33
Related URLs:
URI: http://repository.cshl.edu/id/eprint/7733

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