Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns

Broser, P., Grinevich, V., Osten, P., Sakmann, B., Wallace, D. J. (2008) Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns. Cerebral Cortex, 18 (7). pp. 1588-603. ISSN 1047-3211

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DOI: 10.1093/cercor/bhm189

Abstract

We examined the effect of whisker trimming during early postnatal development on the morphology of axonal arbors in rat somatosensory cortex. Axonal arbors from populations of layer 2/3 pyramidal neurons in the D2 column were labeled by lentivirus-mediated expression of green fluorescent protein. Axonal projection patterns were compared between untrimmed control animals and animals with all whiskers in A-, B-, and C-rows trimmed (D- and E-rows left intact) from postnatal days 7 to 15 (termed from here on DE-pairing). Control animals had approximately symmetrical horizontal projections toward C- and E-row columns in both supra- and infragranular layers. Following DE-pairing, the density of axons in supragranular layers projecting from the labeled neurons in the D2 column was higher in E- than in C-row columns. This asymmetry resulted primarily from a reduction in projection density toward the deprived C-row columns. In contrast, no change was observed in infragranular layers. The results indicate that DE-pairing during early postnatal development results in reduced axonal projection from nondeprived into deprived columns and that cortical neurons are capable of structural rearrangements at subsets of their axonal arbors.

Item Type: Paper
Uncontrolled Keywords: Aging/pathology/physiology Animals Axons/*physiology/*ultrastructure Female Male Nerve Net/physiology Neural Pathways/physiology Neuronal Plasticity/*physiology Pyramidal Cells/*cytology/*physiology Rats Rats, Wistar Somatosensory Cortex/*cytology/*physiology Vibrissae/*innervation/physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > green fluorescent protein
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
organism description > virus
CSHL Authors:
Communities: CSHL labs > Osten lab
Depositing User: Tom Adams
Date Deposited: 26 Aug 2011 13:42
Last Modified: 05 Apr 2013 16:43
PMCID: PMC2430153
Related URLs:
URI: http://repository.cshl.edu/id/eprint/7693

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