Pregnancy and Breast Cancer: Pathways to Understand Risk and Prevention

Slepicka, P. F., Cyrill, S. L., Dos Santos, C. O. (July 2019) Pregnancy and Breast Cancer: Pathways to Understand Risk and Prevention. Trends Mol Med. ISSN 1471-4914

URL: https://www.ncbi.nlm.nih.gov/pubmed/31383623
DOI: 10.1016/j.molmed.2019.06.003

Abstract

Several studies have made strong efforts to understand how age and parity modulate the risk of breast cancer. A holistic understanding of the dynamic regulation of the morphological, cellular, and molecular milieu of the mammary gland offers insights into the drivers of breast cancer development as well as into potential prophylactic interventions, the latter being a longstanding ambition of the research and clinical community aspiring to eradicate the disease. In this review we discuss mechanisms that react to pregnancy signals, and we delineate the nuances of pregnancy-associated dynamism that contribute towards either breast cancer development or prevention. Further definition of the molecular basis of parity and breast cancer risk may allow the elaboration of tools to predict and survey those who are at risk of breast cancer development.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > breast cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics
CSHL Authors:
Communities: CSHL labs > Dos Santos lab
Depositing User: Matthew Dunn
Date: 11 July 2019
Date Deposited: 12 Aug 2019 16:43
Last Modified: 12 Aug 2019 16:43
Related URLs:
URI: http://repository.cshl.edu/id/eprint/38195

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