A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth

Biffi, G., Tuveson, D. A. (May 2019) A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth. Cancer Discov, 9 (5). pp. 578-580. ISSN 2159-8274

URL: https://www.ncbi.nlm.nih.gov/pubmed/31043410
DOI: 10.1158/2159-8290.cd-19-0273

Abstract

In this issue of Cancer Discovery, Auciello and colleagues find that in the pancreatic cancer microenvironment activated fibroblasts secrete specific lipids that provide a source of biomass production and signaling molecules for cancer cells, fueling their proliferation and migration. Targeting of this stromal-tumor metabolic cross-talk impairs pancreatic cancer progression and represents a new potential therapeutic opportunity.See related article by Auciello et al., p. 617.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts

diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matthew Dunn
Date: May 2019
Date Deposited: 29 May 2019 18:08
Last Modified: 29 May 2019 18:08
Related URLs:
URI: http://repository.cshl.edu/id/eprint/37833

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