Tie-Break: Host and Retrotransposons Play tRNA

Schorn, Andrea J., Martienssen, Rob (October 2018) Tie-Break: Host and Retrotransposons Play tRNA. Trends in Cell Biology, 28 (10). pp. 793-806. ISSN 0962-8924

URL: https://www.ncbi.nlm.nih.gov/pubmed/29934075
DOI: 10.1016/j.tcb.2018.05.006

Abstract

tRNA fragments (tRFs) are a class of small, regulatory RNAs with diverse functions. 3′-Derived tRFs perfectly match long terminal repeat (LTR)-retroelements which use the 3′-end of tRNAs to prime reverse transcription. Recent work has shown that tRFs target LTR-retroviruses and -transposons for the RNA interference (RNAi) pathway and also inhibit mobility by blocking reverse transcription. The highly conserved tRNA primer binding site (PBS) in LTR-retroelements is a unique target for 3′-tRFs to recognize and block abundant but diverse LTR-retrotransposons that become transcriptionally active during epigenetic reprogramming in development and disease. 3′-tRFs are processed from full-length tRNAs under so far unknown conditions and potentially protect many cell types. tRFs appear to be an ancient link between RNAi, transposons, and genome stability.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > tRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transposons
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: Matt Covey
Date: October 2018
Date Deposited: 20 Jun 2018 21:00
Last Modified: 20 Dec 2018 20:31
Related URLs:
URI: http://repository.cshl.edu/id/eprint/36752

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