Leukemia cell metabolism in serum of normal, immunized and leukemic mice

Victor, Joseph, Potter, James S. (1938) Leukemia cell metabolism in serum of normal, immunized and leukemic mice. The American Journal of Cancer, 33 (4). pp. 568-577.

URL: http://cancerres.aacrjournals.org/content/33/4/568
DOI: 10.1158/ajc.1938.568

Abstract

Immunization to transplantable lymphatic leukemia in mice results from the suitable injection of leukemia cells (4), normal cells (6), or embryonic tissue (3). Naturally susceptible mice so treated are resistant to injections of normally lethal doses of leukemia cells. Histologically (5) line I leukemia cells injected into mice immunized to line I proliferate for only a short time at a reduced rate and within four days show degenerative changes. Necrosis begins at the periphery of a lesion before there is any infiltration of host cells (5). These findings suggested that a humoral mechanism might be responsible for the degenerative changes in the leukemic cells inoculated into immunized mice.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > leukemia
organism description > animal > mammal > rodent > mouse
Communities: The Carnegie Institution Department of Genetics
Depositing User: Elizabeth Pessala
Date: 1938
Date Deposited: 29 Dec 2017 19:24
Last Modified: 29 Dec 2017 19:24
URI: http://repository.cshl.edu/id/eprint/35791

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