The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas

Ecker, Joseph R., Geschwind, Daniel H., Kriegstein, Arnold R., Ngai, John, Osten, Pavel, Polioudakis, Damon, Regev, Aviv, Sestan, Nenad, Wickersham, Ian R., Zeng, Hongkui (November 2017) The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas. Neuron, 96 (3). pp. 542-557. ISSN 0896-6273

URL: https://www.ncbi.nlm.nih.gov/pubmed/29096072
DOI: 10.1016/j.neuron.2017.10.007

Abstract

A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the experiences of the BRAIN Initiative Cell Census Consortium, ten pilot projects funded by the U.S. BRAIN Initiative, in developing, validating, and scaling up emerging genomic and anatomical mapping technologies for creating a complete inventory of neuronal cell types and their connections in multiple species and during development. These projects lay the foundation for a larger and longer-term effort to generate whole-brain cell atlases in species including mice and humans.

Item Type: Paper
Uncontrolled Keywords: BRAIN initiative mouse brain human brain cell census single-cell RNA-seq single-cell transcriptomics single-cell epigenomics connectivity electrophysiology anatomy
Subjects: Investigative techniques and equipment > brain atlas
CSHL Authors:
Communities: CSHL labs > Osten lab
Depositing User: Matt Covey
Date: 1 November 2017
Date Deposited: 15 Nov 2017 17:38
Last Modified: 15 Nov 2017 17:38
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35661

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