The Role of Long Non-Coding RNAs in Nuclear Organization and Disease

Spector, D. L. (2017) The Role of Long Non-Coding RNAs in Nuclear Organization and Disease. Faseb Journal, 31 (Supple). Meeting Abstract 255.2. ISSN 0892-66381530-6860

URL: http://www.fasebj.org/content/31/1_Supplement/255....

Abstract

Genome-wide analyses have identified approximately 16,000 human long non-coding RNA (lncRNA) genes representing approximately 27% of annotated human genes. LncRNAs tend to localize to cell nuclei implying roles in gene expression and/or nuclear organization. While the number of currently annotated lncRNA genes is close to the number of protein-coding genes we know relatively little in regard to the molecular mechanisms by which these RNA molecules exert their functions. I will discuss an interesting mouse (19qA) and human (11q13.1) genomic region that harbors 2 lncRNA genes, Neat1 and Malat1. Evidence will be presented for an architectural role of Neat1 in the establishment and maintenance of a nuclear domain called paraspeckles, and Malat1 in regulating gene expression and RNA splicing in breast cancer progression.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > breast cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > long non-coding RNA
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Matt Covey
Date Deposited: 31 Aug 2017 19:18
Last Modified: 31 Aug 2017 19:18
URI: http://repository.cshl.edu/id/eprint/35263

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