New roles for Dicer in the nucleolus and its relevance to cancer

Roche, B., Arcangioli, B., Martienssen, R. (September 2017) New roles for Dicer in the nucleolus and its relevance to cancer. Cell Cycle, 16 (18). pp. 1643-1653. ISSN 1551-4005

URL: https://www.ncbi.nlm.nih.gov/pubmed/28846478
DOI: 10.1080/15384101.2017.1361568

Abstract

The nucleolus is a distinct compartment of the nucleus responsible for ribosome biogenesis. Mis-regulation of nucleolar functions and of the cellular translation machinery has been associated with disease, in particular with many types of cancer. Indeed, many tumor suppressors (p53, Rb, PTEN, PICT1, BRCA1) and proto-oncogenes (MYC, NPM) play a direct role in the nucleolus, and interact with the RNA polymerase I transcription machinery and the nucleolar stress response. We have identified Dicer and the RNA interference pathway as having an essential role in the nucleolus of quiescent Schizosaccharomyces pombe cells, distinct from pericentromeric silencing, by controlling RNA polymerase I release. We propose that this novel function is evolutionarily conserved and may contribute to the tumorigenic pre-disposition of DICER1 mutations in mammals.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dicer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > dicer

organs, tissues, organelles, cell types and functions > organelles, types and functions > nucleolus
CSHL Authors:
Communities: CSHL labs > Martienssen lab
CSHL Cancer Center Program > Gene Regulation and Cell Proliferation
Depositing User: Matt Covey
Date: 17 September 2017
Date Deposited: 30 Aug 2017 19:36
Last Modified: 12 Jun 2018 19:23
PMCID: PMC5616133
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35258

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