Microinjection of the catalytic subunit of cAMP-dependent protein kinase induces expression of the c-fos gene

Riabowol, K. T., Gilman, M. Z., Feramisco, J. R. (June 1988) Microinjection of the catalytic subunit of cAMP-dependent protein kinase induces expression of the c-fos gene. Cold Spring Harb Symp Quant Biol, 53 Pt . pp. 85-90. ISSN 1943-4456

URL: https://www.ncbi.nlm.nih.gov/pubmed/2855494
DOI: 10.1101/SQB.1988.053.01.013

Abstract

Changes in the concentration of cAMP have been shown to regulate cell shape (Porter et al. 1974) and metabolism (Schacter et al. 1984) and have been implicated in the inhibition of cell growth (Otten et ai. 1972), although it is now believed that a sustained increase in the cellular level of cAMP constitutes a growth-promoting signal in mammalian (Rozengurt 1986) and yeast (Matsumoto et al. 1985) ceils. In Escherichia coli, the expression of genes encoding enzymes involved in sugar catabolism is activated following binding of cAMP to a catabolite gene-activator protein (cap) and subsequent binding of the complex to specific DNA sequences of cAMP-regulated genes (de Crombrugghe et al. 1984). In

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > c-fos
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: June 1988
Date Deposited: 20 Sep 2017 18:53
Last Modified: 20 Sep 2017 18:53
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35205

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