Transduction of Proto-Src Sequences in Tissue Culture by a Molecular Clone of Transformation-Defective Rous Sarcoma Virus with an Internal Src Deletion

Phares, W. (December 1988) Transduction of Proto-Src Sequences in Tissue Culture by a Molecular Clone of Transformation-Defective Rous Sarcoma Virus with an Internal Src Deletion. Journal of Virology, 62 (12). pp. 4791-4796. ISSN 0022-538X

URL: http://www.ncbi.nlm.nih.gov/pubmed/2460643

Abstract

The sporadic appearance of nondefective (nd) Rous sarcoma virus (RSV) from cells in tissue culture infected with a molecular clone of transformation-defective RSV was examined. Southern analysis of extrachromosomal, virus-specific DNA of three independent ndRSV isolates in each case indicated restoration of an isogenic src by homologous recombination with cellular proto-src. The frequency of transduction was estimated by fluctuation analysis to vary between one transduction per 0.4 .times. 107 to 1.6 .times. 107 infected cells.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > sarcoma
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction

organism description > virus
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: December 1988
Date Deposited: 26 Sep 2017 18:33
Last Modified: 26 Sep 2017 18:33
PMCID: PMC253601
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35195

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