Anti-Oncogenes and the Negative Regulation of Cell-Growth

Horowitz, J. M., Friend, S. H., Weinberg, R. A., Whyte, P., Buchkovich, K., Harlow, E. (June 1988) Anti-Oncogenes and the Negative Regulation of Cell-Growth. Cold Spring Harbor Symposia on Quantitative Biology, 53 (Pt 2). pp. 843-847. ISSN 0091-7451

URL: https://www.ncbi.nlm.nih.gov/pubmed/2908198

Abstract

Normal and neoplastic cell growth is controlled by a complex interacting network of genes and proteins. The number of separate components in this network and the lines of communication between them remain poorly defined. Over the past decade, oncogenes and proto-oncogenes have attracted a great share of the attention of those interested in the molecular biology of cell growth. These genes sit at critical points in this complex signaling network, but they represent only a portion of the key elements controlling cell growth. The oncogenes described to date function in a number of distinct ways (Bishop 1983; Varmus 1984; Weinberg 1985). They may encode cellular proteins in the cytoplasm and nucleus that exert a variety of effects on cell phenotype. These effects include changes in growth factor dependence, morphology, sugar uptake and metabolism, and ability to grow indefinitely in culture (immortalization).

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell regulation
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell signaling
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: June 1988
Date Deposited: 05 Oct 2017 16:14
Last Modified: 05 Oct 2017 16:14
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35167

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