Maintenance of the 2 Micron Circle Plasmid of Saccharomyces-Cerevisiae by Sexual Transmission a Example of a Selfish DNA

Futcher, B., Reid, E., Hickey, D. A. (March 1988) Maintenance of the 2 Micron Circle Plasmid of Saccharomyces-Cerevisiae by Sexual Transmission a Example of a Selfish DNA. Genetics, 118 (3). pp. 411-416. ISSN 0016-6731

URL: http://www.ncbi.nlm.nih.gov/pubmed/3284783

Abstract

Many eukaryotic mobile elements have been identified, but few have any obvious function. This has led to the proposal that many such elements may be parasitic DNA. We have used the 2.mu.m circle plasmid of Saccharomyces cerevisiae as a model system to investigate the maintenance of a cryptic genetic element. We find that under certain conditions this plasmid can spread through experimental populations despite demonstrable selection against it. This spread is dependent upon outbreeding, suggesting that cell to cell transmission of the plasmid during the yeast sexual cycle can counterbalance selection, and maintain the plasmid in populations. This result provides experimental support for the idea that some mobile elements may be parasitic DNA.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > plasmid
organism description > yeast
CSHL Authors:
Depositing User: Gail Sherman
Date: March 1988
Date Deposited: 12 Oct 2017 17:53
Last Modified: 12 Oct 2017 17:53
PMCID: PMC1203295
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35152

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