Subthreshold membrane-potential resonances shape spike-train patterns in the entorhinal cortex

Engel, T. A., Schimansky-Geier, L., Herz, A. V., Schreiber, S., Erchova, I. (2008) Subthreshold membrane-potential resonances shape spike-train patterns in the entorhinal cortex. J Neurophysiol, 100 (3). pp. 1576-89. ISSN 0022-3077 (Print)0022-3077 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/18450582
DOI: 10.1152/jn.01282.2007

Abstract

Many neurons exhibit subthreshold membrane-potential resonances, such that the largest voltage responses occur at preferred stimulation frequencies. Because subthreshold resonances are known to influence the rhythmic activity at the network level, it is vital to understand how they affect spike generation on the single-cell level. We therefore investigated both resonant and nonresonant neurons of rat entorhinal cortex. A minimal resonate-and-fire type model based on measured physiological parameters captures fundamental properties of neuronal firing statistics surprisingly well and helps to shed light on the mechanisms that shape spike patterns: 1) subthreshold resonance together with a spike-induced reset of subthreshold oscillations leads to spike clustering and 2) spike-induced dynamics influence the fine structure of interspike interval (ISI) distributions and are responsible for ISI correlations appearing at higher firing rates (> or =3 Hz). Both mechanisms are likely to account for the specific discharge characteristics of various cell types.

Item Type: Paper
Uncontrolled Keywords: Animals Entorhinal Cortex/*cytology/*physiology Membrane Potentials/*physiology Models, Neurological Neurons/*physiology Nonlinear Dynamics Rats Time Factors
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Engel lab
Depositing User: Matt Covey
Date Deposited: 14 Aug 2017 19:34
Last Modified: 14 Aug 2017 20:54
PMCID: PMC2544463
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35095

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