Same or different? A neural circuit mechanism of similarity-based pattern match decision making

Engel, T. A., Wang, X. J. (2011) Same or different? A neural circuit mechanism of similarity-based pattern match decision making. J Neurosci, 31 (19). pp. 6982-96. ISSN 1529-2401 (Electronic)0270-6474 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/21562260
DOI: 10.1523/JNEUROSCI.6150-10.2011

Abstract

The ability to judge whether sensory stimuli match an internally represented pattern is central to many brain functions. To elucidate the underlying mechanism, we developed a neural circuit model for match/nonmatch decision making. At the core of this model is a "comparison circuit" consisting of two distinct neural populations: match enhancement cells show higher firing response for a match than a nonmatch to the target pattern, and match suppression cells exhibit the opposite trend. We propose that these two neural pools emerge from inhibition-dominated recurrent dynamics and heterogeneous top-down excitation from a working memory circuit. A downstream system learns, through plastic synapses, to extract the necessary information to make match/nonmatch decisions. The model accounts for key physiological observations from behaving monkeys in delayed match-to-sample experiments, including tasks that require more than simple feature match (e.g., when BB in ABBA sequence must be ignored). A testable prediction is that magnitudes of match enhancement and suppression neural signals are parametrically tuned to the similarity between compared patterns. Furthermore, the same neural signals from the comparison circuit can be used differently in the decision process for different stimulus statistics or tasks; reward-dependent synaptic plasticity enables decision neurons to flexibly adjust the readout scheme to task demands, whereby the most informative neural signals have the highest impact on the decision.

Item Type: Paper
Uncontrolled Keywords: Computer Simulation Decision Making/*physiology Discrimination Learning/*physiology Models, Neurological Nerve Net/*physiology Neuronal Plasticity/physiology Neurons/*physiology Synapses/physiology
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Engel lab
Depositing User: Matt Covey
Date Deposited: 14 Aug 2017 20:29
Last Modified: 14 Aug 2017 20:29
PMCID: PMC3110065
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35089

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