Engel, T. A., Chaisangmongkon, W., Freedman, D. J., Wang, X. J. (March 2015) Choice-correlated activity fluctuations underlie learning of neuronal category representation. Nat Commun, 6. p. 6454. ISSN 2041-1723 (Electronic)2041-1723 (Linking)
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Abstract
The ability to categorize stimuli into discrete behaviourally relevant groups is an essential cognitive function. To elucidate the neural mechanisms underlying categorization, we constructed a cortical circuit model that is capable of learning a motion categorization task through reward-dependent plasticity. Here we show that stable category representations develop in neurons intermediate to sensory and decision layers if they exhibit choice-correlated activity fluctuations (choice probability). In the model, choice probability and task-specific interneuronal correlations emerge from plasticity of top-down projections from decision neurons. Specific model predictions are confirmed by analysis of single-neuron activity from the monkey parietal cortex, which reveals a mixture of directional and categorical tuning, and a positive correlation between category selectivity and choice probability. Beyond demonstrating a circuit mechanism for categorization, the present work suggests a key role of plastic top-down feedback in simultaneously shaping both neural tuning and correlated neural variability.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Choice Behavior/physiology Cognition/*physiology Discrimination Learning/*physiology Electrodes, Implanted Feedback, Sensory/physiology Macaca mulatta/physiology Models, Neurological Neurons/cytology/*physiology Parietal Lobe/*physiology Pattern Recognition, Visual/*physiology Reward |
| Subjects: | organism description > animal behavior > perception > cognition organism description > animal behavior > learning organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons |
| CSHL Authors: | |
| Communities: | CSHL labs > Engel lab |
| Depositing User: | Matt Covey |
| Date: | 11 March 2015 |
| Date Deposited: | 14 Aug 2017 20:16 |
| Last Modified: | 10 Sep 2019 18:13 |
| PMCID: | PMC4382677 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35087 |
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