Choice-correlated activity fluctuations underlie learning of neuronal category representation

Engel, T. A., Chaisangmongkon, W., Freedman, D. J., Wang, X. J. (2015) Choice-correlated activity fluctuations underlie learning of neuronal category representation. Nat Commun, 6. p. 6454. ISSN 2041-1723 (Electronic)2041-1723 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/25759251
DOI: 10.1038/ncomms7454

Abstract

The ability to categorize stimuli into discrete behaviourally relevant groups is an essential cognitive function. To elucidate the neural mechanisms underlying categorization, we constructed a cortical circuit model that is capable of learning a motion categorization task through reward-dependent plasticity. Here we show that stable category representations develop in neurons intermediate to sensory and decision layers if they exhibit choice-correlated activity fluctuations (choice probability). In the model, choice probability and task-specific interneuronal correlations emerge from plasticity of top-down projections from decision neurons. Specific model predictions are confirmed by analysis of single-neuron activity from the monkey parietal cortex, which reveals a mixture of directional and categorical tuning, and a positive correlation between category selectivity and choice probability. Beyond demonstrating a circuit mechanism for categorization, the present work suggests a key role of plastic top-down feedback in simultaneously shaping both neural tuning and correlated neural variability.

Item Type: Paper
Uncontrolled Keywords: Animals Choice Behavior/physiology Cognition/*physiology Discrimination Learning/*physiology Electrodes, Implanted Feedback, Sensory/physiology Macaca mulatta/physiology Models, Neurological Neurons/cytology/*physiology Parietal Lobe/*physiology Pattern Recognition, Visual/*physiology Reward
Subjects: organism description > animal behavior > perception > cognition
organism description > animal behavior > learning
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Engel lab
Depositing User: Matt Covey
Date Deposited: 14 Aug 2017 20:16
Last Modified: 14 Aug 2017 20:16
PMCID: PMC4382677
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35087

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving