Selective modulation of cortical state during spatial attention

Engel, T. A., Steinmetz, N. A., Gieselmann, M. A., Thiele, A., Moore, T., Boahen, K. (December 2016) Selective modulation of cortical state during spatial attention. Science, 354 (6316). pp. 1140-1144. ISSN 1095-9203 (Electronic)0036-8075 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/27934763
DOI: 10.1126/science.aag1420

Abstract

Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.

Item Type: Paper
Uncontrolled Keywords: Animals Attention/*physiology Brain Mapping *Goals Macaca mulatta Male Nerve Net/physiology Visual Cortex/*physiology
Subjects: organism description > animal behavior > attention
organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:
Communities: CSHL labs > Engel lab
Depositing User: Matt Covey
Date: 2 December 2016
Date Deposited: 14 Aug 2017 20:49
Last Modified: 14 Aug 2017 20:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/35086

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