Induction of Stress Protein Hsp70 in Nerve-Cells after Status Epilepticus in the Rat

Vass, K., Berger, M. L., Nowak, T. S., Welch, W. J., Lassmann, H. (1989) Induction of Stress Protein Hsp70 in Nerve-Cells after Status Epilepticus in the Rat. Neuroscience Letters, 100 (1-3). pp. 259-264. ISSN 0304-3940

URL: http://www.ncbi.nlm.nih.gov/pubmed/2761775
DOI: 10.1016/0304-3940(89)90695-2

Abstract

The accumulation of the stress protein HSP70 was found to be an excellent marker for prolonged seizure related metabolic activity of neurons. After kainic acid (KA) induced status epilepticus we observed HSP70 immunoreactivity in the hippocampal CA4 and CA1 sectors, the subiculum, the basolateral and the lateral nuclei of the amygdala, the mediodorsal nucleus of the thalamus, the caudal part of the striatum, the claustrum and in neurons of certain neocortical areas. HSP70-positive nerve cells appeared normal in conventional histological stains. Conversely, degenerating neurons (e.g. in the hippocampal CA3 sector) remained unlabeled.

Item Type: Paper
Subjects: diseases & disorders > nervous system diseases and disorders > epilepsy
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date Deposited: 23 Jun 2017 15:17
Last Modified: 23 Jun 2017 15:17
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34914

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