Quantitative autoradiographic localization of NMDA, quisqualate and PCP receptors in the frog tectum

McDonald, J. W., Cline, H. T., Constantine-Paton, M., Maragos, W. F., Johnston, M. V., Young, A. B. (March 1989) Quantitative autoradiographic localization of NMDA, quisqualate and PCP receptors in the frog tectum. Brain Res, 482 (1). pp. 155-8. ISSN 1872-6240

URL: http://www.ncbi.nlm.nih.gov/pubmed/2539881
DOI: 10.1016/0006-8993(89)90553-2

Abstract

An organizing role for the N-methyl-D-aspartate (NMDA) receptor/channel has been suggested in the development of the retinotectal projection in Rana pipiens. The regional distributions of NMDA, phencyclidine (PCP) and quisqualic acid (QA) receptors were quantified using in vitro autoradiography in the tectum of normal and surgically produced 3-eyed juvenile frogs. NMDA and QA receptor binding was highest in the pretectum. Of the tectal layers, the superficial retinotectal synaptic zone, layer 9, had the highest amount of NMDA and QA receptor binding. Moderate binding was observed in layer 5, with little binding in the cellular layer 6. No specific [3H]N-(1-[2-thienyl]cyclohexyl) piperidine ([3H]TCP) binding was observed in any of the tectal regions.

Item Type: Paper
Uncontrolled Keywords: Animals Autoradiography Rana pipiens/*metabolism Receptors, AMPA Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter/*metabolism Receptors, Phencyclidine Superior Colliculus/*metabolism
Subjects: organism description > animal > Frog
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Gail Sherman
Date: 13 March 1989
Date Deposited: 27 Jun 2017 16:33
Last Modified: 27 Jun 2017 16:33
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34877

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving