Cdna Sequence of Neuro-Endocrine Protein 7b2 Expressed in Beta-Cell Tumors of Transgenic Mice

Mbikay, M., Grant, S. G. N., Sirois, F., Tadros, H., Skowronski, J., Lazure, C., Seidah, N. G., Hanahan, D., Chretien, M. (January 1989) Cdna Sequence of Neuro-Endocrine Protein 7b2 Expressed in Beta-Cell Tumors of Transgenic Mice. International Journal of Peptide and Protein Research, 33 (1). pp. 39-45. ISSN 0367-8377

URL: http://www.ncbi.nlm.nih.gov/pubmed/2542174
DOI: 10.1111/j.1399-3011.1989.tb00681.x

Abstract

The cDNA for a widely distributed neuroendocrine protein called 7B2 has been cloned from beta cell tumors of transgenic mice and sequenced. As deduced from the cDNA sequence, 7B2 is a secretory protein of 186 amino acids, nearly identical to its human and porcine homologs. The presence of several pairs of basic residues in the carboxyl terminal portion of the protein suggests that 7B2 can undergo proteolytic maturation in secretory granules and thus generate potential bioactive peptides. 7B2 mRNA is about 1.5 kilobase long and is apparently transcribed from a single gene per haploid genome. The use of tissue-specific promoters to express oncogenes in rare cell types of transgenic mice is a powerful tool for immortalization and expansion of these cells, and it facilitates the isolation and the study of rare proteins such as 7B2.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > cDNA
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: January 1989
Date Deposited: 27 Jun 2017 16:27
Last Modified: 27 Jun 2017 16:27
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34876

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