Specific Chromosomal-Abnormalities Characterize Fibrosarcomas of Bovine Papillomavirus Type-1 Transgenic Mice

Lindgren, V., Sippolathiele, M., Skowronski, J., Wetzel, E., Howley, P. M., Hanahan, D. (July 1989) Specific Chromosomal-Abnormalities Characterize Fibrosarcomas of Bovine Papillomavirus Type-1 Transgenic Mice. Proceedings of the National Academy of Sciences of the United States of America, 86 (13). pp. 5025-5029. ISSN 0027-8424

URL: http://www.ncbi.nlm.nih.gov/pubmed/2544888

Abstract

In the BPV1.69 line of transgenic mice, the bovine papillomavirus type 1 genome elicits both benign dermal fibroblastic proliferation (fibromatoses) and malignant fibrosarcomas. Because these lesions arise only with time, nonviral factors appear to be involved. We have karyotyped several primary tumors as well as a series of low-passage cell lines derived both from fibromatoses and from fibrosarcomas. The fibrosarcomas, but not the preneoplastic fibromatoses, show consistent abnormalities of one or both of two chromosomes, chromosome 8 (trisomy or duplication) and chromosome 14 (monosomy or translocation). The chromosomal abnormalities are not a direct consequence of the viral integration, which we have mapped to chromosome 15 by in situ hybridization. These results suggest that transgenic mice can be used to study the role(s) of cytogenetic changes in tumorigenesis and may direct the search for genes involved in tumor progression.

Item Type: Paper
Subjects: organism description > animal > mammal > rodent > mouse
organism description > virus > papillomavirus
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: July 1989
Date Deposited: 06 Jul 2017 19:06
Last Modified: 06 Jul 2017 19:06
PMCID: PMC297549
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34872

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