A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Greider, C. W., Blackburn, E. H. (January 1989) A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature, 337 (6205). pp. 331-7. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/2463488
DOI: 10.1038/337331a0

Abstract

The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

Item Type: Paper
Uncontrolled Keywords: Animals Base Sequence Chromosomes/*physiology Cloning, Molecular DNA/genetics DNA Nucleotidylexotransferase/*genetics Genes, Structural Molecular Sequence Data Oligonucleotide Probes RNA/*genetics Repetitive Sequences, Nucleic Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Tetrahymena/enzymology/*genetics
Subjects: bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase
CSHL Authors:
Communities: CSHL labs > Greider lab
Depositing User: Gail Sherman
Date: 26 January 1989
Date Deposited: 18 Jul 2017 18:12
Last Modified: 18 Jul 2017 18:12
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34854

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