TRPC Channels and Neuron Development, Plasticity, and Activities

Tai, Y., Jia, Y. (May 2017) TRPC Channels and Neuron Development, Plasticity, and Activities. Adv Exp Med Biol, 976. pp. 95-110. ISSN 0065-2598 (Print)0065-2598

URL: https://www.ncbi.nlm.nih.gov/pubmed/28508316
DOI: 10.1007/978-94-024-1088-4_9

Abstract

In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity. We also notice emerging advances in understanding the functions of TRPC channels in periphery, especially their functions in sensation and nociception in dorsal root ganglion (DRG). Because TRPC channels are expressed in all major types of glial cells, which account for at least half of total cells in the brain, TRPC channels may act as modulators for glial functions as well. The future challenges for studying these channels could be (1) the detailed protein structures of these channels, (2) their cell type-specific functions, (3) requirement for their specific blockers or activators, and (4) change in the channel conformation in the brain.

Item Type: Paper
Uncontrolled Keywords: Development Neuron Plasticity TRPC channels
Subjects: organs, tissues, organelles, cell types and functions > organs types and functions > brain
organism description > animal > developmental stage
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
CSHL Authors:
Communities: CSHL labs > Van Aelst lab
Depositing User: Matt Covey
Date: May 2017
Date Deposited: 19 May 2017 20:10
Last Modified: 19 May 2017 20:10
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34793

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