Comparative transcriptomics in human and mouse

Breschi, A., Gingeras, T. R., Guigo, R. (July 2017) Comparative transcriptomics in human and mouse. Nat Rev Genet, 18 (7). pp. 425-440. ISSN 1471-0056

URL: https://www.ncbi.nlm.nih.gov/pubmed/28479595
DOI: 10.1038/nrg.2017.19

Abstract

Cross-species comparisons of genomes, transcriptomes and gene regulation are now feasible at unprecedented resolution and throughput, enabling the comparison of human and mouse biology at the molecular level. Insights have been gained into the degree of conservation between human and mouse at the level of not only gene expression but also epigenetics and inter-individual variation. However, a number of limitations exist, including incomplete transcriptome characterization and difficulties in identifying orthologous phenotypes and cell types, which are beginning to be addressed by emerging technologies. Ultimately, these comparisons will help to identify the conditions under which the mouse is a suitable model of human physiology and disease, and optimize the use of animal models.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes
organism description > animal > mammal > primates > hominids > human
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transcriptomes
CSHL Authors:
Communities: CSHL labs > Gingeras lab
CSHL Cancer Center Program > Gene Regulation and Cell Proliferation
Depositing User: Matt Covey
Date: July 2017
Date Deposited: 11 May 2017 15:53
Last Modified: 12 Jun 2018 19:30
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34739

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