A descriptive theory of specific precipitation. II. Quantitative applications

Hershey, Alfred Day (1941) A descriptive theory of specific precipitation. II. Quantitative applications. Journal of Immunology, 42 (4). pp. 485-513.

URL: http://www.jimmunol.org/content/42/4/485

Abstract

In the preceding paper we have shown that it is possible to make explicit, often quantitative, predictions concerning the behavior of homogeneous precipitating systems conforming to the lattice-hypothesis. By direct comparison of these predictions with experimental data, we shall be able to judge the degree to which the underlying theory represents the facts. Certain limitations to the quantitative application of the theory should be recalled. Whenever precipitates of the composition r ∼ g1 are encountered, a mechanism not postulated by the lattice-hypothesis is indicated. Any assumption sufficient to account for this mechanism will imply a deviation from the equilibria developed in the general theory. Independently of this mechanism, the single assumption that antigen and antibody are multivalent leads to further deviations postulated by the restricted theory. These effects, deriving from the theory itself, are predictable, however. They are of two kinds.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > antibodies
CSHL Authors:
Communities: The Carnegie Institution Department of Genetics
Depositing User: Matt Covey
Date Deposited: 18 Apr 2017 14:50
Last Modified: 18 Apr 2017 14:50
URI: http://repository.cshl.edu/id/eprint/34545

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