Quantitative methods in the study of the phage-antiphage reaction

Hershey, Alfred Day, Kalmanson, G. M., Bronfenbrenner, Jacques (May 1943) Quantitative methods in the study of the phage-antiphage reaction. Journal of Immunology, 46 (5). pp. 267-279.

URL: http://www.jimmunol.org/content/46/5/267

Abstract

The following characteristics of antiphage-sera have been defined, and methods given for their measurement: specifically precipitable nitrogen, specific rate of neutralization, neutralizing capacity, precipitating activity, and combining power. The significance and precision of measurement of these characteristics are briefly discussed. The methods have been designed specifically to study equilibria in immune reactions, and the question of the homogeneity of the reactants. The specifically precipitable nitrogen of a coli-phage in crude lysates was found to correspond to less than 10−13 mg per lytic unit. This determination provides an additional method for estimating the size of the infective dose of viruses, which can be obtained in sufficient concentration.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > bacteriophage
CSHL Authors:
Communities: The Carnegie Institution Department of Genetics
Depositing User: Matt Covey
Date: May 1943
Date Deposited: 18 Apr 2017 19:19
Last Modified: 18 Apr 2017 19:19
URI: http://repository.cshl.edu/id/eprint/34533

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