FGFR2 is required for airway basal cell self-renewal and terminal differentiation

Balasooriya, G., Goschorska, M., Piddini, E., Rawlins, E. L. (May 2017) FGFR2 is required for airway basal cell self-renewal and terminal differentiation. Development, 144 (9). pp. 1600-1606. ISSN 0950-1991

Abstract

Airway stem cells slowly self-renew and produce differentiated progeny to maintain homeostasis throughout the life-span of an individual. Mutations in the molecular regulators of these processes may drive cancer or degenerative disease, but are also potential therapeutic targets. Conditionally deleting one copy of FGF Receptor 2 in adult mouse airway basal cells results in self-renewal and differentiation phenotypes. We show that FGFR2 signalling correlates with maintenance of expression of a key transcription factor for basal cell self-renewal and differentiation, SOX2. This heterozygous phenotype illustrates that subtle changes in Receptor Tyrosine Kinase signalling can have significant effects, perhaps providing an explanation for the numerous changes seen in cancer.

Item Type:	Paper
Uncontrolled Keywords:	Cre-Lox Lung Mouse Progenitor Trachea
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > differentiation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > fibroblast growth factor bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > Sox2 organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
CSHL Authors:	Balasooriya, Gayan
Communities:	CSHL labs > Spector lab
Depositing User:	Matt Covey
Date:	1 May 2017
Date Deposited:	30 Mar 2017 18:56
Last Modified:	21 Jun 2017 20:46
PMCID:	PMC5450841
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/34296

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