Challenges and Opportunities in Modeling Pancreatic Cancer

Feigin, M. E., Tuveson, D. A. (2017) Challenges and Opportunities in Modeling Pancreatic Cancer. Cold Spring Harb Symp Quant Biol, 81. pp. 231-235. ISSN 0091-7451

URL: https://www.ncbi.nlm.nih.gov/pubmed/28289164
DOI: 10.1101/sqb.2016.81.031104

Abstract

The ability to faithfully model complex processes lies at the heart of experimental biology. Although a reductionist approach necessarily reduces this complexity, it is nevertheless required for untangling the contributions and interactions of the various system components. It has long been appreciated that cancer is a complex process that involves positive and negative interactions between tumor cells, normal host tissue, and the associated cells of the tumor microenvironment. However, accurate models for studying these complex interactions in vitro have remained elusive. We seek to generate models of mouse and human pancreatic cancer that are relevant to disease biology and useful for elucidating poorly understood facets of this deadly disease. The ability to model, manipulate, and predict the therapeutic response of an individual's disease outside their body represents the promise of precision medicine. Therefore, these models are patient-specific and allow the identification of new biomarkers and novel treatment modalities for rapid translation to the clinic. In this perspective we will discuss recent advances in modeling pancreatic cancer in vitro, the discoveries these models have enabled, and future challenges and opportunities awaiting further investigation.

Item Type: Paper
Subjects: organism description > model organism
diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date Deposited: 17 Mar 2017 20:32
Last Modified: 21 Jul 2017 15:34
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34274

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