Growth modulation index as metric of clinical benefit assessment among advanced soft tissue sarcoma patients receiving trabectedin as a salvage therapy

Penel, N., Demetri, G. D., Blay, J. Y., Cousin, S., Maki, R. G., Chawla, S. P., Judson, I., von Mehren, M., Schoffski, P., Verweij, J., Casali, P., Rodenhuis, S., Schutte, H. J., Cassar, A., Gomez, J., Nieto, A., Zintl, P., Pontes, M. J., Le Cesne, A. (February 2013) Growth modulation index as metric of clinical benefit assessment among advanced soft tissue sarcoma patients receiving trabectedin as a salvage therapy. Ann Oncol, 24 (2). pp. 537-42. ISSN 1569-8041 (Electronic)0923-7534 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/23117071
DOI: 10.1093/annonc/mds470

Abstract

BACKGROUND: The growth modulation index (GMI) is the ratio of time to progression with the nth line (TTP(n)) of therapy to the TTP(n)(-1) with the n-1th line. GMI >1.33 is considered as a sign of activity in phase II trials. PATIENTS AND METHODS: This retrospective analysis evaluated the concordance between the GMI and the efficacy outcomes in 279 patients with advanced soft tissue sarcoma (ASTS) treated with trabectedin 1.5 mg/m(2) (24-h infusion every 3 weeks) in four phase II trials. RESULTS: One hundred and forty-two (51%) patients received one prior line and 137 >/= 2 lines. The median TTP(n) was 2.8 months (range 0.2-26.8), whereas the median TTP(n)(-1) was 4.0 months (0.3-79.5). The median GMI was 0.6 (0.0-14.4). Overall, 177 patients (63%) had a GMI <1; 21 (8%) a GMI equal to 1-1.33 and 81 (29%) a GMI >1.33, which correlated with the median overall survival in those patients (9.1, 13.9 and 23.8 months, respectively, P = 0.0005). A high concordance rate between the GMI and response rate (P < 0.0001) and progression-free survival (PFS, P < 0.0001) was observed. Good performance status (PS) was the only factor associated with GMI >1.33 (PS = 0; P < 0.04). CONCLUSIONS: A high GMI was associated with favorable efficacy outcomes in patients treated with trabectedin. Further research is needed to assess GMI as an indicator in this setting.

Item Type: Paper
Uncontrolled Keywords: Adult Aged Aged, 80 and over Antibiotics, Antineoplastic/therapeutic use Antineoplastic Agents, Alkylating/*therapeutic use Cell Proliferation/*drug effects Dioxoles/*therapeutic use Disease-Free Survival Doxorubicin/therapeutic use Female Humans Male Middle Aged Retrospective Studies Salvage Therapy Sarcoma/*drug therapy/metabolism/mortality/pathology Tetrahydroisoquinolines/*therapeutic use Treatment Outcome Young Adult
Subjects: diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > sarcoma
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: February 2013
Date Deposited: 20 Oct 2016 15:35
Last Modified: 20 Oct 2016 15:35
PMCID: PMC4271084
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33757

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