Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series

Italiano, A., Kind, M., Cioffi, A., Maki, R. G., Bui, B. (September 2013) Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series. Target Oncol, 8 (3). pp. 211-3. ISSN 1776-260X (Electronic)1776-2596 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/23292310
DOI: 10.1007/s11523-012-0251-8

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy with poor outcome occurring in adolescents and young adults. Therapeutic options for patients with advanced disease are limited. Preclinical studies have shown that VEGFR-2 and VEGFA are overexpressed in DSRCT and that DSRCT xenografts were highly responsive to anti-VEGF agents such as bevacizumab. We report here the clinical activity of sunitinib in eight patients with DSCRT. Our data suggest that sunitinib may be associated with clinical benefit even in heavily pretreated patients.

Item Type: Paper
Uncontrolled Keywords: Adolescent Adult Antineoplastic Agents/*administration & dosage Desmoplastic Small Round Cell Tumor/*drug therapy/pathology Drug Administration Schedule Humans Indoles/*administration & dosage Male Middle Aged Pyrroles/*administration & dosage Treatment Outcome Young Adult
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > drugs and therapies
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: September 2013
Date Deposited: 20 Oct 2016 16:43
Last Modified: 20 Oct 2016 16:43
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33752

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