Squamous cell carcinoma of the oral tongue in two patients previously exposed to long-term pegylated liposomal doxorubicin

Bonomi, M. R., Misiukiewicz, K., Posner, M., Maki, R. G. (2012) Squamous cell carcinoma of the oral tongue in two patients previously exposed to long-term pegylated liposomal doxorubicin. Oncologist, 17 (12). pp. 1594-5. ISSN 1549-490X (Electronic)1083-7159 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/22622150
DOI: 10.1634/theoncologist.2011-0280

Abstract

Pegylated liposomal doxorubicin (PLD) as single agent is being used in different clinical scenarios, including treatment of recurrent epithelial ovarian cancer, HIV-related Kaposi's sarcoma, and desmoid tumors. Prolonged administration has shown a good safety profile [1–3]. Recently, concerns of a higher risk for oral cavity squamous cell carcinoma in patients with a history of prolonged exposure to PLD was reported [4, 5]. We present two cases of oral tongue cancer in patients who never smoked or drank previously but were exposed to PLD.

Item Type: Paper
Uncontrolled Keywords: Adult Carcinoma, Squamous Cell/*chemically induced/pathology Doxorubicin/administration & dosage/adverse effects/*analogs & derivatives Humans Male Middle Aged Polyethylene Glycols/administration & dosage/*adverse effects Tongue Neoplasms/*chemically induced/pathology
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > drugs and therapies
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: 2012
Date Deposited: 21 Oct 2016 16:29
Last Modified: 21 Oct 2016 16:29
PMCID: PMC3528392
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33727

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